Detail Information

Basic Information:


  VIRBase ID:  

HHID00099026

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-762:           IMPDH1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-762 IMPDH1
miRBase
Accession/Entrez ID		 MIMAT0010313 3614
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IMPD//IMPD1//IMPDH-I//LCA11//RP10//sWSS2608

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-762
rs1379218716 chr16:30893951    G/A
rs1401867087 chr16:30893964    G/A
rs1406702631 chr16:30893966    G/A
rs1407433182 chr16:30893961    C/G
rs374396561 chr16:30893962    C/T
rs751832217 chr16:30893968    C/G
rs752364708 chr16:30893961    CCGGGGCCGAGCCCGCGG/C
rs755205907 chr16:30893971    G/T
rs758841312 chr16:30893963    G/A
rs758841312 chr16:30893963    G/C
rs1241251631 chr16:30893956    T/A
rs1288563923 chr16:30893956    T/TGGGGCC
rs1307177311 chr16:30893953    G/A
rs750763225 chr16:30893954    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IMPDH1
chr7:128043512(-) A-I      intronic
chr7:128043529(-) A-I      intronic
chr7:128043420(-) A-I      intronic
chr7:128032412(-) A-I      3'UTR
chr7:128032420(-) A-I      3'UTR
chr7:128032372(-) A-I      3'UTR
chr7:128032391(-) A-I      3'UTR
chr7:128032393(-) A-I      3'UTR
chr7:128032375(-) A-I      3'UTR
chr7:128032413(-) A-I      3'UTR
chr7:128043394(-) A-I      intronic
chr7:128042253(-) A-I      intronic
chr7:128042294(-) A-I      intronic
chr7:128042350(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IMPDH1
chr7:128032451-128032452(-) m6A 3'UTR       24284625
chr7:128032509-128032510(-) m6A 3'UTR       24284625
chr7:128032871-128032872(-) m6A 3'UTR       24284625
chr7:128032909-128032910(-) m6A 3'UTR       24284625
chr7:128034374-128034375(-) m6A 3'UTR//CDS//exon       27773535
chr7:128034602-128034603(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr7:128034748-128034749(-) m6A exon//intron       27773535//27371828
chr7:128035221-128035222(-) m6A 3'UTR//CDS//exon       22575960
chr7:128035229-128035230(-) m6A 3'UTR//CDS       22575960
chr7:128038591-128038592(-) m6A 3'UTR//CDS//exon       -
chr7:128038597-128038598(-) m6A 3'UTR//CDS//exon       -
chr7:128040215-128040216(-) m6A 3'UTR//CDS//exon       -
chr7:128041105-128041106(-) m6A 3'UTR//CDS//exon       24284625
chr7:128043778-128043779(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr7:128045910-128045911(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chr7:128049526-128049527(-) m6A 5'UTR//CDS//exon//intron       27371828//27773536
chr7:128049871-128049872(-) m6A 5'UTR//CDS//exon       24981863//27371828//27773536
chr7:128050035-128050036(-) m6A 5'UTR//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-762
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
IMPDH1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-762
Gemcitabine 60750 Drug interaction    RC00007981
Imatinib 5291 Drug interaction    RC00007980
Bortezomib 387447 Drug interaction    RC00007983
5-Fluorouracil 3385 Drug interaction    RC00007979
Gefitinib 123631 Drug interaction    RC00007982
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-762
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-762
Interactor2: IMPDH1

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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