Basic Information:

  VIRBase ID:  

HHID00099024

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-762:  MIMAT0010313          HSF4:  NM_001374675     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-762	HSF4
miRBase Accession/Entrez ID	MIMAT0010313	3299
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CTM//CTRCT5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-762	rs1379218716 chr16:30893951    G/A rs1401867087 chr16:30893964    G/A rs1406702631 chr16:30893966    G/A rs1407433182 chr16:30893961    C/G rs374396561 chr16:30893962    C/T rs751832217 chr16:30893968    C/G rs752364708 chr16:30893961    CCGGGGCCGAGCCCGCGG/C rs755205907 chr16:30893971    G/T rs758841312 chr16:30893963    G/A rs758841312 chr16:30893963    G/C rs1241251631 chr16:30893956    T/A rs1288563923 chr16:30893956    T/TGGGGCC rs1307177311 chr16:30893953    G/A rs750763225 chr16:30893954    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSF4	chr16:67198706-67198707(+) m6A 5'UTR//exon       - chr16:67198802-67198803(+) m6A CDS//exon       24981863 chr16:67198814-67198815(+) m6A CDS//exon       24981863 chr16:67198895-67198896(+) m6A exon//intron       24284625//24981863//22575960 chr16:67198925-67198926(+) m6A exon//intron       24284625//24981863//22575960 chr16:67199039-67199040(+) m6A exon//intron       24981863//22575960 chr16:67199055-67199056(+) m6A exon//intron       24981863//22575960 chr16:67199105-67199106(+) m6A exon//intron       24284625//24981863 chr16:67199164-67199165(+) m6A exon//intron       24284625//24981863//22575960//22608085 chr16:67199190-67199191(+) m6A exon//intron       24284625//24209618//24981863//22575960//22608085 chr16:67199226-67199227(+) m6A exon//intron       24284625//24209618//24981863//22575960//22608085 chr16:67199309-67199310(+) m6A exon//intron       24284625//24981863//22575960//22608085 chr16:67199352-67199353(+) m6A exon//intron       24981863 chr16:67199430-67199431(+) m6A CDS//exon//intron       24981863 chr16:67201105-67201106(+) m6A 3'UTR//CDS//exon       - chr16:67201820-67201821(+) m6A 3'UTR//CDS//exon//intron       - chr16:67202759-67202760(+) m6A 3'UTR//CDS//exon       - chr16:67202820-67202821(+) m6A 3'UTR//CDS//exon       - chr16:67202971-67202972(+) m6A 3'UTR//CDS//exon       - chr16:67202981-67202982(+) m6A 3'UTR//CDS//exon       - chr16:67202987-67202988(+) m6A 3'UTR//CDS//exon       - chr16:67203689-67203690(+) m6A 3'UTR//CDS       24284625 chr16:67203715-67203716(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-762	Exosome Pooled sera     27278097 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Hepatoma cells     23771658 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	HSF4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-762	Gemcitabine 60750 Drug interaction    RC00007981 Imatinib 5291 Drug interaction    RC00007980 Bortezomib 387447 Drug interaction    RC00007983 5-Fluorouracil 3385 Drug interaction    RC00007979 Gefitinib 123631 Drug interaction    RC00007982

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-762	Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-762
Interactor2: HSF4

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Downregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.