Detail Information

Basic Information:


  VIRBase ID:  

HHID00099021

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-762:           EPHB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-762 EPHB2
miRBase
Accession/Entrez ID		 MIMAT0010313 2048
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BDPLT22//CAPB//DRT//EK5//EPHT3//ERK//Hek5//PCBC//Tyro5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-762
rs1379218716 chr16:30893951    G/A
rs1401867087 chr16:30893964    G/A
rs1406702631 chr16:30893966    G/A
rs1407433182 chr16:30893961    C/G
rs374396561 chr16:30893962    C/T
rs751832217 chr16:30893968    C/G
rs752364708 chr16:30893961    CCGGGGCCGAGCCCGCGG/C
rs755205907 chr16:30893971    G/T
rs758841312 chr16:30893963    G/A
rs758841312 chr16:30893963    G/C
rs1241251631 chr16:30893956    T/A
rs1288563923 chr16:30893956    T/TGGGGCC
rs1307177311 chr16:30893953    G/A
rs750763225 chr16:30893954    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EPHB2
chr1:23071186(+) A-I      intronic
chr1:23122743(+) A-I      intronic
chr1:23122709(+) A-I      intronic
chr1:23124518(+) A-I      intronic
chr1:23122704(+) A-I      intronic
chr1:23122701(+) A-I      intronic
chr1:23122697(+) A-I      intronic
chr1:23161812(+) A-I      intronic
chr1:23059605(+) A-I      intronic
chr1:23058121(+) A-I      intronic
chr1:23071181(+) A-I      intronic
chr1:23058116(+) A-I      intronic
chr1:23071182(+) A-I      intronic
chr1:23225775(+) A-I      intronic
chr1:23061914(+) A-I      intronic
chr1:23071061(+) A-I      intronic
chr1:23071092(+) A-I      intronic
chr1:23225915(+) A-I      intronic
chr1:23071093(+) A-I      intronic
chr1:23071097(+) A-I      intronic
chr1:23071147(+) A-I      intronic
chr1:23095079(+) A-I      intronic
chr1:23225949(+) A-I      intronic
chr1:23224209(+) A-I      intronic
chr1:23185552(+) A-I      intronic
chr1:23225505(+) A-I      intronic
chr1:23226324(+) A-I      intronic
chr1:23225511(+) A-I      intronic
chr1:23059697(+) A-I      intronic
chr1:23224201(+) A-I      intronic
chr1:23071153(+) A-I      intronic
chr1:23226300(+) A-I      intronic
chr1:23071369(+) A-I      intronic
chr1:23226339(+) A-I      intronic
chr1:23094998(+) A-I      intronic
chr1:23114036(+) A-I      intronic
chr1:23161717(+) A-I      intronic
chr1:23061658(+) A-I      intronic
chr1:23140571(+) A-I      intronic
chr1:23059671(+) A-I      intronic
chr1:23161320(+) A-I      intronic
chr1:23095048(+) A-I      intronic
chr1:23069133(+) A-I      intronic
chr1:23226304(+) A-I      intronic
chr1:23134539(+) A-I      intronic
chr1:23211016(+) A-I      intronic
chr1:23228351(+) A-I      intronic
chr1:23108680(+) A-I      intronic
chr1:23228221(+) A-I      intronic
chr1:23224475(+) A-I      intronic
chr1:23118045(+) A-I      intronic
chr1:23216349(+) A-I      intronic
chr1:23079550(+) A-I      intronic
chr1:23228455(+) A-I      intronic
chr1:23061887(+) A-I      intronic
chr1:23146899(+) A-I      intronic
chr1:23071295(+) A-I      intronic
chr1:23215410(+) A-I      intronic
chr1:23218388(+) A-I      intronic
chr1:23228461(+) A-I      intronic
chr1:23146904(+) A-I      intronic
chr1:23228553(+) A-I      intronic
chr1:23224515(+) A-I      intronic
chr1:23161610(+) A-I      intronic
chr1:23228524(+) A-I      intronic
chr1:23071078(+) A-I      intronic
chr1:23095002(+) A-I      intronic
chr1:23225463(+) A-I      intronic
chr1:23225839(+) A-I      intronic
chr1:23225873(+) A-I      intronic
chr1:23213302(+) A-I      intronic
chr1:23114048(+) A-I      intronic
chr1:23115284(+) A-I      intronic
chr1:23044132(+) A-I      intronic
chr1:23058262(+) A-I      intronic
chr1:23215467(+) A-I      intronic
chr1:23079410(+) A-I      intronic
chr1:23228448(+) A-I      intronic
chr1:23059681(+) A-I      intronic
chr1:23228384(+) A-I      intronic
chr1:23084302(+) A-I      intronic
chr1:23071087(+) A-I      intronic
chr1:23226365(+) A-I      intronic
chr1:23228571(+) A-I      intronic
chr1:23108699(+) A-I      intronic
chr1:23228519(+) A-I      intronic
chr1:23226376(+) A-I      intronic
chr1:23061660(+) A-I      intronic
chr1:23060995(+) A-I      intronic
chr1:23117998(+) A-I      intronic
chr1:23071367(+) A-I      intronic
chr1:23228458(+) A-I      intronic
chr1:23134516(+) A-I      intronic
chr1:23208348(+) A-I      intronic
chr1:23071228(+) A-I      intronic
chr1:23095162(+) A-I      intronic
chr1:23207710(+) A-I      intronic
chr1:23228405(+) A-I      intronic
chr1:23218382(+) A-I      intronic
chr1:23134451(+) A-I      intronic
chr1:23059722(+) A-I      intronic
chr1:23224012(+) A-I      intronic
chr1:23114010(+) A-I      intronic
chr1:23225731(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EPHB2
chr1:23107925-23107926(+) m6A CDS       22608085
chr1:23110912-23110913(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr1:23110918-23110919(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr1:23110966-23110967(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr1:23110980-23110981(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr1:23111085-23111086(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23111133-23111134(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23111209-23111210(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:23111258-23111259(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr1:23111296-23111297(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr1:23111385-23111386(+) m6A CDS       24284625//24981863
chr1:23191413-23191414(+) m6A CDS//exon       24284625
chr1:23191434-23191435(+) m6A CDS//exon       24284625//24981863
chr1:23191465-23191466(+) m6A CDS//exon       24284625//24981863
chr1:23191531-23191532(+) m6A CDS//exon       24284625//24981863
chr1:23191684-23191685(+) m6A CDS//exon       24284625
chr1:23208896-23208897(+) m6A CDS//exon       24284625
chr1:23208926-23208927(+) m6A CDS//exon       24284625
chr1:23208950-23208951(+) m6A CDS//exon       24284625
chr1:23240007-23240008(+) m6A 3'UTR//CDS       24284625
chr1:23240037-23240038(+) m6A 3'UTR//CDS       24284625
chr1:23240189-23240190(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr1:23240225-23240226(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr1:23240273-23240274(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085
chr1:23240403-23240404(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:23240460-23240461(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:23240474-23240475(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:23240493-23240494(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:23240568-23240569(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23240576-23240577(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23240595-23240596(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23240634-23240635(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23240672-23240673(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23240685-23240686(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr1:23240756-23240757(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:23240883-23240884(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:23240969-23240970(+) m6A 3'UTR       24209618//25456834//24981863//22608085
chr1:23241094-23241095(+) m6A 3'UTR       24981863
chr1:23241280-23241281(+) m6A 3'UTR       24209618//25456834//24981863
chr1:23241342-23241343(+) m6A 3'UTR       24209618//25456834//24981863
chr1:23241358-23241359(+) m6A 3'UTR       24209618//25456834//24981863
chr1:23241498-23241499(+) m6A 3'UTR       24981863
chr1:23241524-23241525(+) m6A 3'UTR       24981863
chr1:23241547-23241548(+) m6A 3'UTR       24981863
chr1:23245819-23245820(+) m6A 3'UTR       24981863
chr1:23245850-23245851(+) m6A 3'UTR       24981863
chr1:23245858-23245859(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-762
Exosome Pooled sera     27278097
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
EPHB2
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-762
Gemcitabine 60750 Drug interaction    RC00007981
Imatinib 5291 Drug interaction    RC00007980
Bortezomib 387447 Drug interaction    RC00007983
5-Fluorouracil 3385 Drug interaction    RC00007979
Gefitinib 123631 Drug interaction    RC00007982
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-762
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-762
Interactor2: EPHB2

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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