Basic Information:

  VIRBase ID:  

HHID00099008

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          IYD:  NM_001318495     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	IYD
miRBase Accession/Entrez ID	MIMAT0005929	389434
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C6orf71//DEHAL1//IYD-1//TDH4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IYD	chr6:150713259(+) A-I      intronic chr6:150718510(+) A-I      intronic chr6:150712284(+) A-I      intronic chr6:150718567(+) A-I      intronic chr6:150718599(+) A-I      intronic chr6:150712343(+) A-I      intronic chr6:150713283(+) A-I      intronic chr6:150713011(+) A-I      intronic chr6:150712187(+) A-I      intronic chr6:150712113(+) A-I      intronic chr6:150712098(+) A-I      intronic chr6:150718626(+) A-I      intronic chr6:150708455(+) A-I      intronic chr6:150713206(+) A-I      intronic chr6:150713290(+) A-I      intronic chr6:150718431(+) A-I      intronic chr6:150718509(+) A-I      intronic chr6:150712226(+) A-I      intronic chr6:150712242(+) A-I      intronic chr6:150712275(+) A-I      intronic chr6:150720060(+) A-I      3'UTR chr6:150720077(+) A-I      3'UTR chr6:150720078(+) A-I      3'UTR chr6:150720158(+) A-I      3'UTR chr6:150720159(+) A-I      3'UTR chr6:150720161(+) A-I      3'UTR chr6:150724115(+) A-I      3'UTR chr6:150724133(+) A-I      3'UTR chr6:150724138(+) A-I      3'UTR chr6:150724150(+) A-I      3'UTR chr6:150724163(+) A-I      3'UTR chr6:150724164(+) A-I      3'UTR chr6:150724168(+) A-I      3'UTR chr6:150724176(+) A-I      3'UTR chr6:150724189(+) A-I      3'UTR chr6:150720136(+) A-I      3'UTR chr6:150720144(+) A-I      3'UTR chr6:150720139(+) A-I      3'UTR chr6:150720083(+) A-I      3'UTR chr6:150720064(+) A-I      3'UTR chr6:150719922(+) A-I      3'UTR chr6:150719969(+) A-I      3'UTR chr6:150716093(+) A-I      intronic chr6:150712262(+) A-I      intronic chr6:150713222(+) A-I      intronic chr6:150713277(+) A-I      intronic chr6:150716091(+) A-I      intronic chr6:150724112(+) A-I      3'UTR chr6:150724143(+) A-I      3'UTR chr6:150720103(+) A-I      3'UTR chr6:150724103(+) A-I      3'UTR chr6:150720091(+) A-I      3'UTR chr6:150712119(+) A-I      intronic chr6:150718645(+) A-I      intronic chr6:150712164(+) A-I      intronic chr6:150718443(+) A-I      intronic chr6:150713294(+) A-I      intronic chr6:150710158(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	IYD	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: IYD

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.