Basic Information:

  VIRBase ID:  

HHID00099007

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          ATXN1L:  NM_001137675     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	ATXN1L
miRBase Accession/Entrez ID	MIMAT0005929	342371
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BOAT//BOAT1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATXN1L	chr16:71892629(+) A-I      intronic chr16:71892635(+) A-I      intronic chr16:71892610(+) A-I      intronic chr16:71907766(+) A-I      intronic chr16:71892567(+) A-I      intronic chr16:71892007(+) A-I      intronic chr16:71892283(+) A-I      intronic chr16:71892296(+) A-I      intronic chr16:71892075(+) A-I      intronic chr16:71892290(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATXN1L	chr16:71892251(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATXN1L	chr16:71881933-71881934(+) m6A 5'UTR//exon       24284625 chr16:71881968-71881969(+) m6A 5'UTR//exon       24284625 chr16:71882035-71882036(+) m6A exon//intron       24284625//24981863 chr16:71882040-71882041(+) m6A exon//intron       24284625//24981863 chr16:71882298-71882299(+) m6A exon//intron       - chr16:71883628-71883629(+) m6A 5'UTR//intron       24284625//24209618 chr16:71883648-71883649(+) m6A CDS//intron       24284625//24209618 chr16:71883695-71883696(+) m6A CDS//intron       24284625//24209618//24981863 chr16:71883727-71883728(+) m6A CDS//intron       24284625//24209618//24981863 chr16:71883872-71883873(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71883930-71883931(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr16:71884304-71884305(+) m6A CDS//intron       24284625//24209618//24981863 chr16:71884375-71884376(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr16:71884455-71884456(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:71884461-71884462(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:71884536-71884537(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:71884569-71884570(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:71884591-71884592(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884630-71884631(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884637-71884638(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884685-71884686(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884719-71884720(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884787-71884788(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71884848-71884849(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884857-71884858(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884863-71884864(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884915-71884916(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr16:71884997-71884998(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885102-71885103(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885110-71885111(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885177-71885178(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885399-71885400(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr16:71885502-71885503(+) Cm CDS//intron       - chr16:71885713-71885714(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr16:71885726-71885727(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr16:71885732-71885733(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr16:71885903-71885904(+) m6A 3'UTR//intron       24284625 chr16:71886204-71886205(+) m6A 3'UTR//intron       - chr16:71888680-71888681(+) m6A 3'UTR//intron       - chr16:71888736-71888737(+) m6A 3'UTR//intron       - chr16:71889482-71889483(+) m6A 3'UTR//intron       24981863 chr16:71889541-71889542(+) m6A 3'UTR//intron       24981863//27773535 chr16:71893696-71893697(+) m6A intron       - chr16:71893796-71893797(+) m6A intron       - chr16:71893822-71893823(+) m6A intron       - chr16:71894060-71894061(+) m6A intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	ATXN1L	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: ATXN1L

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.