Basic Information:

  VIRBase ID:  

HHID00099005

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          STXBP4:  NM_178509     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	STXBP4
miRBase Accession/Entrez ID	MIMAT0005929	252983
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Synip

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STXBP4	chr17:53226029(+) A-I      intronic chr17:53235527(+) A-I      intronic chr17:53235510(+) A-I      intronic chr17:53102484(+) A-I      intronic chr17:53102454(+) A-I      intronic chr17:53102422(+) A-I      intronic chr17:53102419(+) A-I      intronic chr17:53225993(+) A-I      intronic chr17:53066002(+) A-I      intronic chr17:53065974(+) A-I      intronic chr17:53201218(+) A-I      intronic chr17:53174903(+) A-I      intronic chr17:53173719(+) A-I      intronic chr17:53144196(+) A-I      intronic chr17:53144193(+) A-I      intronic chr17:53081799(+) A-I      intronic chr17:53081785(+) A-I      intronic chr17:53081302(+) A-I      intronic chr17:53081278(+) A-I      intronic chr17:53069521(+) A-I      intronic chr17:53235567(+) A-I      intronic chr17:53144222(+) A-I      intronic chr17:53235451(+) A-I      intronic chr17:53217584(+) A-I      intronic chr17:53066090(+) A-I      intronic chr17:53066029(+) A-I      intronic chr17:53217611(+) A-I      intronic chr17:53143654(+) A-I      intronic chr17:53174873(+) A-I      intronic chr17:53143655(+) A-I      intronic chr17:53081418(+) A-I      intronic chr17:53128079(+) A-I      intronic chr17:53063881(+) A-I      intronic chr17:53235518(+) A-I      intronic chr17:53236582(+) A-I      intronic chr17:53236390(+) A-I      intronic chr17:53235541(+) A-I      intronic chr17:53063894(+) A-I      intronic chr17:53223918(+) A-I      intronic chr17:53143702(+) A-I      intronic chr17:53129100(+) A-I      intronic chr17:53235524(+) A-I      intronic chr17:53201240(+) A-I      intronic chr17:53081425(+) A-I      intronic chr17:53139354(+) A-I      intronic chr17:53128988(+) A-I      intronic chr17:53063846(+) A-I      intronic chr17:53066079(+) A-I      intronic chr17:53235523(+) A-I      intronic chr17:53235573(+) A-I      intronic chr17:53160611(+) A-I      intronic chr17:53066119(+) A-I      intronic chr17:53144115(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STXBP4	chr17:53121233(+) A-I intron -    15258596 chr17:53121310(+) A-I intron -    15258596 chr17:53121322(+) A-I intron -    15258596 chr17:53121927(+) A-I intron -    15258596 chr17:53121931(+) A-I intron -    15258596 chr17:53121932(+) A-I intron -    15258596 chr17:53121233(+) A-G intron -    22484847 chr17:53121896(+) A-G intron -    22484847 chr17:53121973(+) A-G intron -    22484847 chr17:53235524(+) A-G intron -    22484847 chr17:53235541(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STXBP4	chr17:53077097-53077098(+) m6A CDS       24981863 chr17:53077155-53077156(+) m6A CDS       24981863 chr17:53077173-53077174(+) m6A CDS       24981863 chr17:53078174-53078175(+) m6A CDS       24981863 chr17:53237170-53237171(+) m6A CDS       22608085 chr17:53237250-53237251(+) m6A CDS       24284625//24981863//22608085 chr17:53237344-53237345(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr17:53237397-53237398(+) m6A 3'UTR       24981863//22608085 chr17:53237404-53237405(+) m6A 3'UTR       24981863//22608085 chr17:53237424-53237425(+) m6A 3'UTR       24981863//22608085 chr17:53239528-53239529(+) Y 3'UTR       26075521 chr17:53241208-53241209(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	STXBP4	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: STXBP4

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.