Basic Information:

  VIRBase ID:  

HHID00098998

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          WNK4:  NM_032387     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	WNK4
miRBase Accession/Entrez ID	MIMAT0005929	65266
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PHA2B//PRKWNK4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WNK4	chr17:40945496(+) A-I      intronic chr17:40945395(+) A-I      intronic chr17:40945346(+) A-I      intronic chr17:40941524(+) A-I      intronic chr17:40941495(+) A-I      intronic chr17:40941494(+) A-I      intronic chr17:40941413(+) A-I      intronic chr17:40943844(+) A-I      intronic chr17:40941411(+) A-I      intronic chr17:40941841(+) A-I      intronic chr17:40941616(+) A-I      intronic chr17:40943863(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WNK4	chr17:40938579(+) T-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WNK4	chr17:40932978-40932979(+) m6A CDS       - chr17:40933027-40933028(+) m6A CDS       22608085 chr17:40933046-40933047(+) m6A CDS       22608085 chr17:40933077-40933078(+) m6A CDS       24209618//25456834//24981863//22608085 chr17:40933101-40933102(+) m6A CDS       24209618//25456834//24981863//22608085 chr17:40933191-40933192(+) m6A CDS       25456834//24981863//22608085 chr17:40933199-40933200(+) m6A CDS       25456834//24981863//22608085 chr17:40933293-40933294(+) m6A CDS       - chr17:40934783-40934784(+) m6A CDS       - chr17:40936098-40936099(+) m6A CDS//exon       24981863 chr17:40936124-40936125(+) m6A CDS//exon       24981863 chr17:40936441-40936442(+) m6A CDS//exon       24981863 chr17:40937432-40937433(+) m6A CDS//exon       24981863 chr17:40946321-40946322(+) m6A exon//intron       27773535 chr17:40946436-40946437(+) m6A exon//intron       27773535 chr17:40946458-40946459(+) m6A exon//intron       27773535 chr17:40947748-40947749(+) m6A 3'UTR//CDS       - chr17:40947792-40947793(+) m6A 3'UTR//CDS       - chr17:40947815-40947816(+) m6A 3'UTR//CDS       - chr17:40947898-40947899(+) m6A 3'UTR//CDS       - chr17:40947954-40947955(+) m6A 3'UTR//CDS       - chr17:40948878-40948879(+) m6A 3'UTR       24981863 chr17:40948888-40948889(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	WNK4	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: WNK4

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.