Basic Information:

  VIRBase ID:  

HHID00098997

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          ZSWIM4:  NM_001367834     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	ZSWIM4
miRBase Accession/Entrez ID	MIMAT0005929	65249
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZSWIM4	chr19:13911760(+) A-I      intronic chr19:13920889(+) A-I      intronic chr19:13911746(+) A-I      intronic chr19:13922664(+) A-I      intronic chr19:13924549(+) A-I      intronic chr19:13924539(+) A-I      intronic chr19:13922674(+) A-I      intronic chr19:13922679(+) A-I      intronic chr19:13922712(+) A-I      intronic chr19:13922713(+) A-I      intronic chr19:13922727(+) A-I      intronic chr19:13915370(+) A-I      intronic chr19:13920888(+) A-I      intronic chr19:13920822(+) A-I      intronic chr19:13922730(+) A-I      intronic chr19:13922750(+) A-I      intronic chr19:13924479(+) A-I      intronic chr19:13913615(+) A-I      intronic chr19:13913590(+) A-I      intronic chr19:13913497(+) A-I      intronic chr19:13915272(+) A-I      intronic chr19:13911794(+) A-I      intronic chr19:13924480(+) A-I      intronic chr19:13924510(+) A-I      intronic chr19:13911793(+) A-I      intronic chr19:13911778(+) A-I      intronic chr19:13911772(+) A-I      intronic chr19:13911769(+) A-I      intronic chr19:13915271(+) A-I      intronic chr19:13924525(+) A-I      intronic chr19:13915249(+) A-I      intronic chr19:13915241(+) A-I      intronic chr19:13915234(+) A-I      intronic chr19:13914504(+) A-I      intronic chr19:13914460(+) A-I      intronic chr19:13914419(+) A-I      intronic chr19:13920823(+) A-I      intronic chr19:13915099(+) A-I      intronic chr19:13915164(+) A-I      intronic chr19:13915239(+) A-I      intronic chr19:13915346(+) A-I      intronic chr19:13913550(+) A-I      intronic chr19:13915367(+) A-I      intronic chr19:13915406(+) A-I      intronic chr19:13915418(+) A-I      intronic chr19:13916974(+) A-I      intronic chr19:13917057(+) A-I      intronic chr19:13917066(+) A-I      intronic chr19:13920320(+) A-I      intronic chr19:13920413(+) A-I      intronic chr19:13921443(+) A-I      intronic chr19:13921485(+) A-I      intronic chr19:13921504(+) A-I      intronic chr19:13921541(+) A-I      intronic chr19:13921553(+) A-I      intronic chr19:13915350(+) A-I      intronic chr19:13921767(+) A-I      intronic chr19:13908763(+) A-I      intronic chr19:13910205(+) A-I      intronic chr19:13911452(+) A-I      intronic chr19:13911731(+) A-I      intronic chr19:13911863(+) A-I      intronic chr19:13912572(+) A-I      intronic chr19:13912579(+) A-I      intronic chr19:13912674(+) A-I      intronic chr19:13913555(+) A-I      intronic chr19:13913614(+) A-I      intronic chr19:13913627(+) A-I      intronic chr19:13913658(+) A-I      intronic chr19:13912773(+) A-I      intronic chr19:13914431(+) A-I      intronic chr19:13914458(+) A-I      intronic chr19:13914462(+) A-I      intronic chr19:13914464(+) A-I      intronic chr19:13914467(+) A-I      intronic chr19:13914499(+) A-I      intronic chr19:13921845(+) A-I      intronic chr19:13921864(+) A-I      intronic chr19:13921909(+) A-I      intronic chr19:13921934(+) A-I      intronic chr19:13922201(+) A-I      intronic chr19:13922272(+) A-I      intronic chr19:13922285(+) A-I      intronic chr19:13922301(+) A-I      intronic chr19:13922332(+) A-I      intronic chr19:13922355(+) A-I      intronic chr19:13922356(+) A-I      intronic chr19:13922357(+) A-I      intronic chr19:13922731(+) A-I      intronic chr19:13922746(+) A-I      intronic chr19:13922769(+) A-I      intronic chr19:13926025(+) A-I      intronic chr19:13926026(+) A-I      intronic chr19:13926033(+) A-I      intronic chr19:13926063(+) A-I      intronic chr19:13926070(+) A-I      intronic chr19:13926099(+) A-I      intronic chr19:13914521(+) A-I      intronic chr19:13914740(+) A-I      intronic chr19:13915056(+) A-I      intronic chr19:13915095(+) A-I      intronic chr19:13915098(+) A-I      intronic chr19:13926109(+) A-I      intronic chr19:13912851(+) A-I      intronic chr19:13912876(+) A-I      intronic chr19:13913232(+) A-I      intronic chr19:13913243(+) A-I      intronic chr19:13913247(+) A-I      intronic chr19:13913279(+) A-I      intronic chr19:13913288(+) A-I      intronic chr19:13913300(+) A-I      intronic chr19:13913309(+) A-I      intronic chr19:13913315(+) A-I      intronic chr19:13913326(+) A-I      intronic chr19:13913343(+) A-I      intronic chr19:13913492(+) A-I      intronic chr19:13926198(+) A-I      intronic chr19:13926244(+) A-I      intronic chr19:13927399(+) A-I      intronic chr19:13930894(+) A-I      intronic chr19:13931942(+) A-I      intronic chr19:13932010(+) A-I      intronic chr19:13932017(+) A-I      intronic chr19:13932018(+) A-I      intronic chr19:13932055(+) A-I      intronic chr19:13932253(+) A-I      intronic chr19:13932461(+) A-I      intronic chr19:13932493(+) A-I      intronic chr19:13932676(+) A-I      intronic chr19:13932726(+) A-I      intronic chr19:13932735(+) A-I      intronic chr19:13932741(+) A-I      intronic chr19:13932757(+) A-I      intronic chr19:13933423(+) A-I      intronic chr19:13933776(+) A-I      intronic chr19:13933844(+) A-I      intronic chr19:13937865(+) A-I      intronic chr19:13937994(+) A-I      intronic chr19:13938421(+) A-I      intronic chr19:13938426(+) A-I      intronic chr19:13939041(+) A-I      intronic chr19:13916986(+) A-I      intronic chr19:13921609(+) A-I      intronic chr19:13914569(+) A-I      intronic chr19:13937524(+) A-I      intronic chr19:13919468(+) A-I      intronic chr19:13915424(+) A-I      intronic chr19:13911468(+) A-I      intronic chr19:13913522(+) A-I      intronic chr19:13914991(+) A-I      intronic chr19:13913190(+) A-I      intronic chr19:13933822(+) A-I      intronic chr19:13924471(+) A-I      intronic chr19:13914498(+) A-I      intronic chr19:13912997(+) A-I      intronic chr19:13930935(+) A-I      intronic chr19:13912615(+) A-I      intronic chr19:13911460(+) A-I      intronic chr19:13913207(+) A-I      intronic chr19:13911842(+) A-I      intronic chr19:13922223(+) A-I      intronic chr19:13917266(+) A-I      intronic chr19:13911774(+) A-I      intronic chr19:13914939(+) A-I      intronic chr19:13911406(+) A-I      intronic chr19:13921563(+) A-I      intronic chr19:13921573(+) A-I      intronic chr19:13913510(+) A-I      intronic chr19:13921631(+) A-I      intronic chr19:13921287(+) A-I      intronic chr19:13917377(+) A-I      intronic chr19:13932773(+) A-I      intronic chr19:13913493(+) A-I      intronic chr19:13921018(+) A-I      intronic chr19:13911483(+) A-I      intronic chr19:13913667(+) A-I      intronic chr19:13915340(+) A-I      intronic chr19:13935345(+) A-I      intronic chr19:13914861(+) A-I      intronic chr19:13914338(+) A-I      intronic chr19:13912560(+) A-I      intronic chr19:13911694(+) A-I      intronic chr19:13922259(+) A-I      intronic chr19:13914416(+) A-I      intronic chr19:13939793(+) A-I      intronic chr19:13932225(+) A-I      intronic chr19:13932494(+) A-I      intronic chr19:13915030(+) A-I      intronic chr19:13911775(+) A-I      intronic chr19:13913274(+) A-I      intronic chr19:13926204(+) A-I      intronic chr19:13911403(+) A-I      intronic chr19:13908606(+) A-I      intronic chr19:13916590(+) A-I      intronic chr19:13916621(+) A-I      intronic chr19:13914539(+) A-I      intronic chr19:13921857(+) A-I      intronic chr19:13911797(+) A-I      intronic chr19:13932297(+) A-I      intronic chr19:13923161(+) A-I      intronic chr19:13926659(+) A-I      intronic chr19:13914417(+) A-I      intronic chr19:13911428(+) A-I      intronic chr19:13938089(+) A-I      intronic chr19:13911937(+) A-I      intronic chr19:13912972(+) A-I      intronic chr19:13922628(+) A-I      intronic chr19:13911858(+) A-I      intronic chr19:13926566(+) A-I      intronic chr19:13926389(+) A-I      intronic chr19:13924588(+) A-I      intronic chr19:13921468(+) A-I      intronic chr19:13913080(+) A-I      intronic chr19:13914842(+) A-I      intronic chr19:13913576(+) A-I      intronic chr19:13913208(+) A-I      intronic chr19:13920504(+) A-I      intronic chr19:13914958(+) A-I      intronic chr19:13912907(+) A-I      intronic chr19:13913462(+) A-I      intronic chr19:13917427(+) A-I      intronic chr19:13920546(+) A-I      intronic chr19:13922207(+) A-I      intronic chr19:13911727(+) A-I      intronic chr19:13911018(+) A-I      intronic chr19:13917022(+) A-I      intronic chr19:13926662(+) A-I      intronic chr19:13914456(+) A-I      intronic chr19:13915236(+) A-I      intronic chr19:13923188(+) A-I      intronic chr19:13913322(+) A-I      intronic chr19:13940010(+) A-I      intronic chr19:13914525(+) A-I      intronic chr19:13910962(+) A-I      intronic chr19:13914573(+) A-I      intronic chr19:13913344(+) A-I      intronic chr19:13915341(+) A-I      intronic chr19:13913532(+) A-I      intronic chr19:13914952(+) A-I      intronic chr19:13910419(+) A-I      intronic chr19:13915029(+) A-I      intronic chr19:13911707(+) A-I      intronic chr19:13926714(+) A-I      intronic chr19:13922729(+) A-I      intronic chr19:13911747(+) A-I      intronic chr19:13922642(+) A-I      intronic chr19:13921789(+) A-I      intronic chr19:13922705(+) A-I      intronic chr19:13922742(+) A-I      intronic chr19:13925789(+) A-I      intronic chr19:13920376(+) A-I      intronic chr19:13914516(+) A-I      intronic chr19:13922457(+) A-I      intronic chr19:13912555(+) A-I      intronic chr19:13922703(+) A-I      intronic chr19:13933629(+) A-I      intronic chr19:13932564(+) A-I      intronic chr19:13912668(+) A-I      intronic chr19:13921503(+) A-I      intronic chr19:13922405(+) A-I      intronic chr19:13920948(+) A-I      intronic chr19:13922438(+) A-I      intronic chr19:13913349(+) A-I      intronic chr19:13913443(+) A-I      intronic chr19:13912586(+) A-I      intronic chr19:13927832(+) A-I      intronic chr19:13927252(+) A-I      intronic chr19:13935166(+) A-I      intronic chr19:13914453(+) A-I      intronic chr19:13912854(+) A-I      intronic chr19:13926665(+) A-I      intronic chr19:13909613(+) A-I      intronic chr19:13935425(+) A-I      intronic chr19:13914472(+) A-I      intronic chr19:13911501(+) A-I      intronic chr19:13917299(+) A-I      intronic chr19:13932250(+) A-I      intronic chr19:13914341(+) A-I      intronic chr19:13913566(+) A-I      intronic chr19:13935210(+) A-I      intronic chr19:13914465(+) A-I      intronic chr19:13922618(+) A-I      intronic chr19:13925829(+) A-I      intronic chr19:13913448(+) A-I      intronic chr19:13915431(+) A-I      intronic chr19:13911810(+) A-I      intronic chr19:13917252(+) A-I      intronic chr19:13914544(+) A-I      intronic chr19:13910956(+) A-I      intronic chr19:13911901(+) A-I      intronic chr19:13912627(+) A-I      intronic chr19:13922633(+) A-I      intronic chr19:13913424(+) A-I      intronic chr19:13929452(+) A-I      intronic chr19:13915364(+) A-I      intronic chr19:13931977(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZSWIM4	chr19:13911901(+) A-I intron -    22327324 chr19:13911727(+) A-G intron -    22484847 chr19:13911747(+) A-G intron -    22484847 chr19:13911754(+) A-G intron -    22484847 chr19:13911901(+) A-G intron -    22484847 chr19:13914472(+) A-G intron -    22484847 chr19:13914544(+) A-G intron -    22484847 chr19:13921063(+) A-G intron -    22484847 chr19:13926665(+) A-G intron -    22484847 chr19:13926712(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZSWIM4	chr19:13906411-13906412(+) m6A 5'UTR       24209618//25456834//27371828//27773536 chr19:13906467-13906468(+) m6A CDS       24209618//25456834//27371828//27773536 chr19:13906506-13906507(+) m6A CDS       24209618//27371828 chr19:13919658-13919659(+) m6A CDS       24284625 chr19:13919908-13919909(+) m6A CDS       24284625//25456834//22575960 chr19:13919959-13919960(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:13920004-13920005(+) m6A CDS       24284625//25456834//24981863 chr19:13923850-13923851(+) m6A CDS       24284625//25456834 chr19:13923894-13923895(+) m6A CDS       24284625 chr19:13925487-13925488(+) m6A CDS//intron       24284625//25456834 chr19:13925533-13925534(+) m6A CDS//intron       24284625//24209618//25456834 chr19:13925562-13925563(+) m6A CDS//intron       24284625//24209618//25456834 chr19:13928535-13928536(+) m6A CDS       24284625 chr19:13928682-13928683(+) m6A CDS       24284625 chr19:13941034-13941035(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941124-13941125(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941190-13941191(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941199-13941200(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941235-13941236(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941409-13941410(+) m6A CDS       24284625//24209618//25456834//24981863 chr19:13941552-13941553(+) m6A CDS       24284625//24209618//25456834//24981863 chr19:13941747-13941748(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941799-13941800(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941806-13941807(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:13941830-13941831(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:13941867-13941868(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr19:13942050-13942051(+) m6A 3'UTR       24284625//25456834 chr19:13942153-13942154(+) m6A 3'UTR       24284625//25456834//24981863 chr19:13942168-13942169(+) m6A 3'UTR       24284625//25456834//24981863 chr19:13942205-13942206(+) m6A 3'UTR       24284625//25456834//24981863 chr19:13942343-13942344(+) m6A 3'UTR       - chr19:13942427-13942428(+) m6A 3'UTR       24284625 chr19:13942532-13942533(+) m6A 3'UTR       24284625//25456834//24981863 chr19:13942576-13942577(+) m6A 3'UTR       25456834//24981863 chr19:13942599-13942600(+) m6A 3'UTR       25456834//24981863 chr19:13942821-13942822(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	ZSWIM4	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: ZSWIM4

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.