Basic Information:

  VIRBase ID:  

HHID00098994

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          CCDC113:  NM_014157     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	CCDC113
miRBase Accession/Entrez ID	MIMAT0005929	29070
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC065

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCDC113	chr16:58311125(+) A-I      intronic chr16:58311150(+) A-I      intronic chr16:58311158(+) A-I      intronic chr16:58311162(+) A-I      intronic chr16:58311137(+) A-I      intronic chr16:58311136(+) A-I      intronic chr16:58311133(+) A-I      intronic chr16:58311132(+) A-I      intronic chr16:58289509(+) A-I      intronic chr16:58285457(+) A-I      intronic chr16:58285453(+) A-I      intronic chr16:58316052(+) A-I      3'UTR chr16:58316042(+) A-I      3'UTR chr16:58316070(+) A-I      3'UTR chr16:58316030(+) A-I      3'UTR chr16:58291836(+) A-I      intronic chr16:58292788(+) A-I      intronic chr16:58311214(+) A-I      intronic chr16:58285435(+) A-I      intronic chr16:58291756(+) A-I      intronic chr16:58287048(+) A-I      intronic chr16:58285558(+) A-I      intronic chr16:58285349(+) A-I      intronic chr16:58287062(+) A-I      intronic chr16:58311216(+) A-I      intronic chr16:58293163(+) A-I      intronic chr16:58292762(+) A-I      intronic chr16:58292794(+) A-I      intronic chr16:58289643(+) A-I      intronic chr16:58285557(+) A-I      intronic chr16:58292802(+) A-I      intronic chr16:58303155(+) A-I      intronic chr16:58311307(+) A-I      intronic chr16:58285570(+) A-I      intronic chr16:58284414(+) A-I      intronic chr16:58300037(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCDC113	chr16:58287931-58287932(+) m6A CDS//intron       24209618//24981863 chr16:58287941-58287942(+) m6A CDS//intron       24209618//24981863 chr16:58287972-58287973(+) m6A CDS//intron       24209618//24981863 chr16:58301472-58301473(+) m6A CDS       24981863 chr16:58312491-58312492(+) m6A CDS       24981863 chr16:58313883-58313884(+) m6A 3'UTR       24981863 chr16:58314046-58314047(+) m6A 3'UTR       24981863 chr16:58314058-58314059(+) m6A 3'UTR       24981863 chr16:58314126-58314127(+) m6A 3'UTR       24981863 chr16:58314149-58314150(+) m6A 3'UTR       24981863 chr16:58314164-58314165(+) m6A 3'UTR       24981863 chr16:58314561-58314562(+) m6A 3'UTR       24981863 chr16:58314596-58314597(+) m6A 3'UTR       24981863 chr16:58314608-58314609(+) m6A 3'UTR       24981863 chr16:58314621-58314622(+) m6A 3'UTR       24981863 chr16:58314673-58314674(+) m6A 3'UTR       24981863 chr16:58314698-58314699(+) m6A 3'UTR       24981863 chr16:58315610-58315611(+) m6A 3'UTR       24981863 chr16:58315616-58315617(+) m6A 3'UTR       24981863 chr16:58315648-58315649(+) m6A 3'UTR       24981863 chr16:58315657-58315658(+) m6A 3'UTR       24981863 chr16:58315666-58315667(+) m6A 3'UTR       24981863 chr16:58315721-58315722(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	CCDC113	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: CCDC113

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.