Basic Information:

  VIRBase ID:  

HHID00098990

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          ABLIM3:  NM_001345858     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	ABLIM3
miRBase Accession/Entrez ID	MIMAT0005929	22885
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HMFN1661

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ABLIM3	chr5:148572138(+) A-I      intronic chr5:148570198(+) A-I      intronic chr5:148632760(+) A-I      intronic chr5:148632762(+) A-I      intronic chr5:148632766(+) A-I      intronic chr5:148632786(+) A-I      intronic chr5:148632815(+) A-I      intronic chr5:148632816(+) A-I      intronic chr5:148632817(+) A-I      intronic chr5:148632855(+) A-I      intronic chr5:148632830(+) A-I      intronic chr5:148632814(+) A-I      intronic chr5:148632802(+) A-I      intronic chr5:148634784(+) A-I      intronic chr5:148634796(+) A-I      intronic chr5:148634696(+) A-I      intronic chr5:148634826(+) A-I      intronic chr5:148634667(+) A-I      intronic chr5:148634717(+) A-I      intronic chr5:148634708(+) A-I      intronic chr5:148634678(+) A-I      intronic chr5:148632943(+) A-I      intronic chr5:148632929(+) A-I      intronic chr5:148634668(+) A-I      intronic chr5:148632901(+) A-I      intronic chr5:148634694(+) A-I      intronic chr5:148632759(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ABLIM3	chr5:148596531(+) A-I exon CDS    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ABLIM3	chr5:148521402-148521403(+) m6A 5'UTR//intron       24981863 chr5:148521494-148521495(+) m6A 5'UTR//intron       - chr5:148521505-148521506(+) m6A 5'UTR//intron       - chr5:148521551-148521552(+) m6A 5'UTR//intron       - chr5:148632383-148632384(+) m6A 3'UTR//CDS//exon       24981863 chr5:148632388-148632389(+) m6A 3'UTR//CDS//exon       24981863 chr5:148637939-148637940(+) m6A 3'UTR//CDS//exon//intron       24981863 chr5:148638059-148638060(+) m6A 3'UTR//exon//intron       24981863 chr5:148639222-148639223(+) m6A 3'UTR       - chr5:148639259-148639260(+) m6A 3'UTR       24209618 chr5:148639324-148639325(+) m6A 3'UTR       24209618//24981863//27773535 chr5:148639414-148639415(+) m6A 3'UTR       24284625//24209618//24981863//27773535 chr5:148639429-148639430(+) m6A 3'UTR       24284625//24209618//24981863//27773535 chr5:148639526-148639527(+) m6A 3'UTR       24209618//24981863//27773535 chr5:148639581-148639582(+) m6A 3'UTR       24209618//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: ABLIM3

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.