Basic Information:

  VIRBase ID:  

HHID00098989

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          CNTNAP1:  NM_003632     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	CNTNAP1
miRBase Accession/Entrez ID	MIMAT0005929	8506
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CASPR//CHN3//CNTNAP//NRXN4//P190

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CNTNAP1	chr17:40837701(+) A-I      intronic chr17:40848937(+) A-I      intronic chr17:40848930(+) A-I      intronic chr17:40848503(+) A-I      intronic chr17:40848422(+) A-I      intronic chr17:40848442(+) A-I      intronic chr17:40848411(+) A-I      intronic chr17:40848421(+) A-I      intronic chr17:40848717(+) A-I      intronic chr17:40848784(+) A-I      intronic chr17:40848800(+) A-I      intronic chr17:40848982(+) A-I      intronic chr17:40848367(+) A-I      intronic chr17:40846412(+) A-I      intronic chr17:40845861(+) A-I      intronic chr17:40848765(+) A-I      intronic chr17:40846347(+) A-I      intronic chr17:40846563(+) A-I      intronic chr17:40848713(+) A-I      intronic chr17:40848550(+) A-I      intronic chr17:40848617(+) A-I      intronic chr17:40846294(+) A-I      intronic chr17:40845825(+) A-I      intronic chr17:40845854(+) A-I      intronic chr17:40845963(+) A-I      intronic chr17:40848914(+) A-I      intronic chr17:40845839(+) A-I      intronic chr17:40842426(+) A-I      intronic chr17:40848588(+) A-I      intronic chr17:40845856(+) A-I      intronic chr17:40845902(+) A-I      intronic chr17:40845996(+) A-I      intronic chr17:40845807(+) A-I      intronic chr17:40846503(+) A-I      intronic chr17:40846387(+) A-I      intronic chr17:40846654(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CNTNAP1	chr17:40846532(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CNTNAP1	chr17:40834642-40834643(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834649-40834650(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834684-40834685(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834755-40834756(+) m6A 5'UTR       24209618//25456834//24981863 chr17:40834788-40834789(+) m6A 5'UTR       24209618//24981863 chr17:40834833-40834834(+) m6A 5'UTR       24209618//24981863 chr17:40839870-40839871(+) m6A CDS//exon       27371828 chr17:40851093-40851094(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	CNTNAP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: CNTNAP1

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.