Detail Information

Basic Information:


  VIRBase ID:  

HHID00098988

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           SPOCK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 SPOCK1
miRBase
Accession/Entrez ID		 MIMAT0005929 6695
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - SPOCK//TESTICAN//TIC1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SPOCK1
chr5:136770261(-) A-I      intronic
chr5:136400773(-) A-I      intronic
chr5:136400779(-) A-I      intronic
chr5:136402010(-) A-I      intronic
chr5:136688975(-) A-I      intronic
chr5:136691010(-) A-I      intronic
chr5:136690716(-) A-I      intronic
chr5:136690730(-) A-I      intronic
chr5:136691077(-) A-I      intronic
chr5:136691104(-) A-I      intronic
chr5:136737219(-) A-I      intronic
chr5:136770385(-) A-I      intronic
chr5:136400760(-) A-I      intronic
chr5:136400754(-) A-I      intronic
chr5:136400751(-) A-I      intronic
chr5:136400745(-) A-I      intronic
chr5:136400712(-) A-I      intronic
chr5:136770300(-) A-I      intronic
chr5:136760270(-) A-I      intronic
chr5:136770314(-) A-I      intronic
chr5:136770317(-) A-I      intronic
chr5:136770408(-) A-I      intronic
chr5:136770424(-) A-I      intronic
chr5:136771734(-) A-I      intronic
chr5:136818922(-) A-I      intronic
chr5:136818927(-) A-I      intronic
chr5:136818983(-) A-I      intronic
chr5:136818984(-) A-I      intronic
chr5:136644708(-) A-I      intronic
chr5:136644709(-) A-I      intronic
chr5:136644710(-) A-I      intronic
chr5:136644729(-) A-I      intronic
chr5:136644734(-) A-I      intronic
chr5:136690810(-) A-I      intronic
chr5:136566787(-) A-I      intronic
chr5:136771717(-) A-I      intronic
chr5:136688886(-) A-I      intronic
chr5:136783680(-) A-I      intronic
chr5:136771841(-) A-I      intronic
chr5:136770353(-) A-I      intronic
chr5:136606634(-) A-I      intronic
chr5:136770462(-) A-I      intronic
chr5:136771790(-) A-I      intronic
chr5:136770285(-) A-I      intronic
chr5:136770326(-) A-I      intronic
chr5:136771587(-) A-I      intronic
chr5:136811514(-) A-I      intronic
chr5:136737175(-) A-I      intronic
chr5:136402109(-) A-I      intronic
chr5:136770356(-) A-I      intronic
chr5:136698190(-) A-I      intronic
chr5:136566985(-) A-I      intronic
chr5:136771737(-) A-I      intronic
chr5:136401895(-) A-I      intronic
chr5:136737399(-) A-I      intronic
chr5:136771838(-) A-I      intronic
chr5:136770265(-) A-I      intronic
chr5:136740380(-) A-I      intronic
chr5:136812519(-) A-I      intronic
chr5:136698198(-) A-I      intronic
chr5:136771723(-) A-I      intronic
chr5:136770463(-) A-I      intronic
chr5:136566958(-) A-I      intronic
chr5:136812514(-) A-I      intronic
chr5:136771833(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPOCK1
chr5:136312646-136312647(-) m6A 3'UTR       24981863
chr5:136312674-136312675(-) m6A 3'UTR       24981863
chr5:136312705-136312706(-) m6A 3'UTR       24981863
chr5:136314205-136314206(-) m6A 3'UTR//exon       24209618//24981863
chr5:136314268-136314269(-) m6A 3'UTR//exon       24209618//24981863
chr5:136314324-136314325(-) m6A 3'UTR//exon       24209618//25456834//24981863
chr5:136314439-136314440(-) m6A CDS//exon       24284625//24209618//25456834//24981863
chr5:136314447-136314448(-) m6A CDS//exon       24284625//24209618//25456834//24981863
chr5:136314518-136314519(-) m6A CDS//exon       24209618//24981863
chr5:136315039-136315040(-) m6A CDS//exon       24209618//24981863
chr5:136315073-136315074(-) m6A CDS//exon       24209618
chr5:136834128-136834129(-) m6A CDS//intron       27773536
chr5:136834885-136834886(-) m6A 5'UTR//intron       24209618//24981863//27773536
chr5:136834893-136834894(-) m6A 5'UTR//intron       24209618//24981863//27773536
chr5:136841354-136841355(-) m6A exon       24981863
chr5:136841360-136841361(-) m6A exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
SPOCK1
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: SPOCK1

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Upregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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