Detail Information

Basic Information:


  VIRBase ID:  

HHID00098985

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           KCNQ2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 KCNQ2
miRBase
Accession/Entrez ID		 MIMAT0005929 3785
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BFNC//DEE7//EBN//EBN1//ENB1//HNSPC//KCNA11//KV7.2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KCNQ2
chr20:62067746(-) A-I      intronic
chr20:62082409(-) A-I      intronic
chr20:62066665(-) A-I      intronic
chr20:62079037(-) A-I      intronic
chr20:62067832(-) A-I      intronic
chr20:62068268(-) A-I      intronic
chr20:62090658(-) A-I      intronic
chr20:62069300(-) A-I      intronic
chr20:62066628(-) A-I      intronic
chr20:62068297(-) A-I      intronic
chr20:62069225(-) A-I      intronic
chr20:62069366(-) A-I      intronic
chr20:62067640(-) A-I      intronic
chr20:62082343(-) A-I      intronic
chr20:62082325(-) A-I      intronic
chr20:62067641(-) A-I      intronic
chr20:62066516(-) A-I      intronic
chr20:62072356(-) A-I      intronic
chr20:62068197(-) A-I      intronic
chr20:62068302(-) A-I      intronic
chr20:62066619(-) A-I      intronic
chr20:62066576(-) A-I      intronic
chr20:62079045(-) A-I      intronic
chr20:62072417(-) A-I      intronic
chr20:62069433(-) A-I      intronic
chr20:62068311(-) A-I      intronic
chr20:62067628(-) A-I      intronic
chr20:62079177(-) A-I      intronic
chr20:62067762(-) A-I      intronic
chr20:62067772(-) A-I      intronic
chr20:62068405(-) A-I      intronic
chr20:62068391(-) A-I      intronic
chr20:62066550(-) A-I      intronic
chr20:62068404(-) A-I      intronic
chr20:62066679(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KCNQ2
chr20:62032677-62032678(-) m6A 3'UTR//intron       -
chr20:62032751-62032752(-) m6A 3'UTR//intron       -
chr20:62032795-62032796(-) m6A 3'UTR//intron       -
chr20:62032833-62032834(-) m6A 3'UTR//intron       -
chr20:62033025-62033026(-) m6A 3'UTR//intron       -
chr20:62033147-62033148(-) m6A 3'UTR//intron       -
chr20:62033165-62033166(-) m6A 3'UTR//intron       -
chr20:62033206-62033207(-) m6A 3'UTR//intron       -
chr20:62033260-62033261(-) m6A 3'UTR//intron       -
chr20:62033319-62033320(-) m6A 3'UTR//intron       -
chr20:62033378-62033379(-) m6A 3'UTR//intron       -
chr20:62033437-62033438(-) m6A 3'UTR//intron       -
chr20:62033494-62033495(-) m6A 3'UTR//intron       -
chr20:62033500-62033501(-) m6A 3'UTR//intron       -
chr20:62033553-62033554(-) m6A 3'UTR//intron       -
chr20:62033612-62033613(-) m6A 3'UTR//intron       -
chr20:62037557-62037558(-) m6A 3'UTR//intron       25456834
chr20:62037589-62037590(-) m6A 3'UTR//intron       25456834
chr20:62037925-62037926(-) m6A 3'UTR//intron       25456834//22608085
chr20:62037976-62037977(-) m6A 3'UTR//intron       25456834//22608085
chr20:62038096-62038097(-) m6A CDS//intron       25456834//22575960
chr20:62038177-62038178(-) m6A CDS//intron       25456834//22575960//22608085
chr20:62038234-62038235(-) m6A CDS//intron       25456834//27773536//22608085
chr20:62038267-62038268(-) m6A CDS//intron       25456834//27773536//22608085
chr20:62038276-62038277(-) m6A CDS//intron       25456834//27773536//22608085
chr20:62038306-62038307(-) m6A CDS//intron       25456834//27773536//22608085
chr20:62038411-62038412(-) m6A CDS//intron       25456834//27773536
chr20:62038516-62038517(-) m6A CDS//intron       25456834//24981863//27773536
chr20:62038591-62038592(-) m6A CDS//intron       25456834//24981863
chr20:62038652-62038653(-) m6A CDS//intron       25456834
chr20:62038702-62038703(-) m6A CDS//intron       25456834
chr20:62039805-62039806(-) m6A CDS//intron       -
chr20:62071018-62071019(-) m6A CDS//exon       27773536
chr20:62071032-62071033(-) m6A CDS//exon       27773536
chr20:62103648-62103649(-) m6A CDS//exon       27773536
chr20:62103733-62103734(-) m6A CDS//exon       27773536
chr20:62103761-62103762(-) m1A CDS//exon       26863410
chr20:62103933-62103934(-) m6A 5'UTR//exon       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
KCNQ2
Exosome Blood     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: KCNQ2

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Upregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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