Basic Information:

  VIRBase ID:  

HHID00098983

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:  MIMAT0005929          EGR3:  NM_001199880     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-1275	EGR3
miRBase Accession/Entrez ID	MIMAT0005929	1960
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EGR-3//PILOT

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-1275	rs372458638 chr6:34000019    A/AAAACC rs377188203 chr6:34000023    C/T rs557928121 chr6:34000019    A/T rs758811783 chr6:34000022    G/A rs761034364 chr6:34000017    AGAC/A rs370361021 chr6:34000029    C/A rs370361021 chr6:34000029    C/T rs374728385 chr6:34000032    C/A rs374728385 chr6:34000032    C/G rs747378297 chr6:34000028    C/T rs772691699 chr6:34000033    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EGR3	chr8:22546823(-) A-I exon 3'UTR    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EGR3	chr8:22545508-22545509(-) m6A 3'UTR       26404942 chr8:22545541-22545542(-) m6A 3'UTR       26404942 chr8:22545569-22545570(-) m6A 3'UTR       26404942 chr8:22545577-22545578(-) m6A 3'UTR       26404942 chr8:22545603-22545604(-) m6A 3'UTR       26404942 chr8:22545715-22545716(-) m6A 3'UTR       26404942 chr8:22545727-22545728(-) m6A 3'UTR       26404942 chr8:22545738-22545739(-) m6A 3'UTR       26404942 chr8:22545909-22545910(-) m6A 3'UTR       26404942 chr8:22545998-22545999(-) m6A 3'UTR       28052920//26404942 chr8:22546057-22546058(-) m6A 3'UTR       28052920//26404942 chr8:22547371-22547372(-) m6A 3'UTR       26404942 chr8:22547392-22547393(-) m6A 3'UTR       26404942 chr8:22547405-22547406(-) m6A 3'UTR       26404942 chr8:22547576-22547577(-) m6A 3'UTR       28052920//26404942//27371828 chr8:22547621-22547622(-) m6A 3'UTR       28052920//26404942//27371828 chr8:22547659-22547660(-) m6A 3'UTR       28052920//26404942//27371828 chr8:22547670-22547671(-) m6A 3'UTR       28052920//26404942//27371828 chr8:22548347-22548348(-) m6A 3'UTR//CDS//exon       28052920//27371828 chr8:22548442-22548443(-) m6A 3'UTR//CDS//exon       24284625//28052920//27371828 chr8:22548461-22548462(-) m6A 3'UTR//CDS//exon       24284625//28052920//27371828 chr8:22548502-22548503(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27371828 chr8:22548598-22548599(-) m6A 3'UTR//CDS//exon       24284625//28052920//26404942//27371828 chr8:22548850-22548851(-) m6A 3'UTR//CDS//exon       24284625//26404942 chr8:22548905-22548906(-) m6A 3'UTR//CDS//exon       26404942 chr8:22548948-22548949(-) m6A 3'UTR//CDS//exon       26404942 chr8:22548982-22548983(-) m6A 3'UTR//CDS//exon       26404942 chr8:22550586-22550587(-) m6A 5'UTR       28052920//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-1275	Exosome Breast cancer cell line (MCF-7)     20976003 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Cell line (HeLa)     21695135 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus HeLa cells     23940654
	EGR3	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-1275	Gemcitabine 60750 Drug interaction    RC00007825 Vincristine 5978 Drug interaction    RC00007823 Eloxatine 5310940 Drug interaction    RC00007826 Paclitaxel 36314 Drug interaction    RC00007824 5-Fluorouracil 3385 Drug interaction    RC00007822 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821 Marine fungal metabolite 1386A - Drug interaction    RC00007827

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-1275	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-1275
Interactor2: EGR3

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.