Basic Information:

  VIRBase ID:  

HHID00098976

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-1-3p:  MIMAT0004499          STXBP4:  NM_178509     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26a-1-3p	STXBP4
miRBase Accession/Entrez ID	MIMAT0004499	252983
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Synip

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26a-1-3p	rs182070256 chr3:37969473    G/A rs771522629 chr3:37969472    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STXBP4	chr17:53226029(+) A-I      intronic chr17:53235527(+) A-I      intronic chr17:53235510(+) A-I      intronic chr17:53102484(+) A-I      intronic chr17:53102454(+) A-I      intronic chr17:53102422(+) A-I      intronic chr17:53102419(+) A-I      intronic chr17:53225993(+) A-I      intronic chr17:53066002(+) A-I      intronic chr17:53065974(+) A-I      intronic chr17:53201218(+) A-I      intronic chr17:53174903(+) A-I      intronic chr17:53173719(+) A-I      intronic chr17:53144196(+) A-I      intronic chr17:53144193(+) A-I      intronic chr17:53081799(+) A-I      intronic chr17:53081785(+) A-I      intronic chr17:53081302(+) A-I      intronic chr17:53081278(+) A-I      intronic chr17:53069521(+) A-I      intronic chr17:53235567(+) A-I      intronic chr17:53144222(+) A-I      intronic chr17:53235451(+) A-I      intronic chr17:53217584(+) A-I      intronic chr17:53066090(+) A-I      intronic chr17:53066029(+) A-I      intronic chr17:53217611(+) A-I      intronic chr17:53143654(+) A-I      intronic chr17:53174873(+) A-I      intronic chr17:53143655(+) A-I      intronic chr17:53081418(+) A-I      intronic chr17:53128079(+) A-I      intronic chr17:53063881(+) A-I      intronic chr17:53235518(+) A-I      intronic chr17:53236582(+) A-I      intronic chr17:53236390(+) A-I      intronic chr17:53235541(+) A-I      intronic chr17:53063894(+) A-I      intronic chr17:53223918(+) A-I      intronic chr17:53143702(+) A-I      intronic chr17:53129100(+) A-I      intronic chr17:53235524(+) A-I      intronic chr17:53201240(+) A-I      intronic chr17:53081425(+) A-I      intronic chr17:53139354(+) A-I      intronic chr17:53128988(+) A-I      intronic chr17:53063846(+) A-I      intronic chr17:53066079(+) A-I      intronic chr17:53235523(+) A-I      intronic chr17:53235573(+) A-I      intronic chr17:53160611(+) A-I      intronic chr17:53066119(+) A-I      intronic chr17:53144115(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STXBP4	chr17:53121233(+) A-I intron -    15258596 chr17:53121310(+) A-I intron -    15258596 chr17:53121322(+) A-I intron -    15258596 chr17:53121927(+) A-I intron -    15258596 chr17:53121931(+) A-I intron -    15258596 chr17:53121932(+) A-I intron -    15258596 chr17:53121233(+) A-G intron -    22484847 chr17:53121896(+) A-G intron -    22484847 chr17:53121973(+) A-G intron -    22484847 chr17:53235524(+) A-G intron -    22484847 chr17:53235541(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STXBP4	chr17:53077097-53077098(+) m6A CDS       24981863 chr17:53077155-53077156(+) m6A CDS       24981863 chr17:53077173-53077174(+) m6A CDS       24981863 chr17:53078174-53078175(+) m6A CDS       24981863 chr17:53237170-53237171(+) m6A CDS       22608085 chr17:53237250-53237251(+) m6A CDS       24284625//24981863//22608085 chr17:53237344-53237345(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr17:53237397-53237398(+) m6A 3'UTR       24981863//22608085 chr17:53237404-53237405(+) m6A 3'UTR       24981863//22608085 chr17:53237424-53237425(+) m6A 3'UTR       24981863//22608085 chr17:53239528-53239529(+) Y 3'UTR       26075521 chr17:53241208-53241209(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26a-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	STXBP4	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26a-1-3p
Interactor2: STXBP4

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.