Basic Information:

  VIRBase ID:  

HHID00098972

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-1-3p:  MIMAT0004499          WWC2:  NM_024949     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26a-1-3p	WWC2
miRBase Accession/Entrez ID	MIMAT0004499	80014
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BOMB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26a-1-3p	rs182070256 chr3:37969473    G/A rs771522629 chr3:37969472    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WWC2	chr4:184195856(+) A-I      intronic chr4:184218028(+) A-I      intronic chr4:184151646(+) A-I      intronic chr4:184151736(+) A-I      intronic chr4:184027337(+) A-I      intronic chr4:184027266(+) A-I      intronic chr4:184213480(+) A-I      intronic chr4:184213479(+) A-I      intronic chr4:184213274(+) A-I      intronic chr4:184027212(+) A-I      intronic chr4:184026262(+) A-I      intronic chr4:184026189(+) A-I      intronic chr4:184026256(+) A-I      intronic chr4:184032220(+) A-I      intronic chr4:184034235(+) A-I      intronic chr4:184034247(+) A-I      intronic chr4:184034305(+) A-I      intronic chr4:184195829(+) A-I      intronic chr4:184195832(+) A-I      intronic chr4:184034314(+) A-I      intronic chr4:184108976(+) A-I      intronic chr4:184231811(+) A-I      intronic chr4:184218202(+) A-I      intronic chr4:184034331(+) A-I      intronic chr4:184034346(+) A-I      intronic chr4:184048110(+) A-I      intronic chr4:184049159(+) A-I      intronic chr4:184218837(+) A-I      intronic chr4:184049401(+) A-I      intronic chr4:184049593(+) A-I      intronic chr4:184073420(+) A-I      intronic chr4:184074268(+) A-I      intronic chr4:184074916(+) A-I      intronic chr4:184099430(+) A-I      intronic chr4:184107213(+) A-I      intronic chr4:184032965(+) A-I      intronic chr4:184032960(+) A-I      intronic chr4:184028427(+) A-I      intronic chr4:184152911(+) A-I      intronic chr4:184211524(+) A-I      intronic chr4:184218593(+) A-I      intronic chr4:184218197(+) A-I      intronic chr4:184218037(+) A-I      intronic chr4:184218032(+) A-I      intronic chr4:184217993(+) A-I      intronic chr4:184108958(+) A-I      intronic chr4:184108967(+) A-I      intronic chr4:184214249(+) A-I      intronic chr4:184214170(+) A-I      intronic chr4:184213483(+) A-I      intronic chr4:184213157(+) A-I      intronic chr4:184195850(+) A-I      intronic chr4:184195839(+) A-I      intronic chr4:184195838(+) A-I      intronic chr4:184109469(+) A-I      intronic chr4:184109548(+) A-I      intronic chr4:184130564(+) A-I      intronic chr4:184151081(+) A-I      intronic chr4:184195857(+) A-I      intronic chr4:184073470(+) A-I      intronic chr4:184049424(+) A-I      intronic chr4:184049420(+) A-I      intronic chr4:184049381(+) A-I      intronic chr4:184033060(+) A-I      intronic chr4:184033005(+) A-I      intronic chr4:184151568(+) A-I      intronic chr4:184151212(+) A-I      intronic chr4:184141787(+) A-I      intronic chr4:184141771(+) A-I      intronic chr4:184132390(+) A-I      intronic chr4:184195867(+) A-I      intronic chr4:184109565(+) A-I      intronic chr4:184195881(+) A-I      intronic chr4:184151687(+) A-I      intronic chr4:184151693(+) A-I      intronic chr4:184151709(+) A-I      intronic chr4:184151710(+) A-I      intronic chr4:184218207(+) A-I      intronic chr4:184218240(+) A-I      intronic chr4:184193038(+) A-I      intronic chr4:184039136(+) A-I      intronic chr4:184218227(+) A-I      intronic chr4:184074204(+) A-I      intronic chr4:184217854(+) A-I      intronic chr4:184032318(+) A-I      intronic chr4:184032314(+) A-I      intronic chr4:184194657(+) A-I      intronic chr4:184027210(+) A-I      intronic chr4:184109556(+) A-I      intronic chr4:184218624(+) A-I      intronic chr4:184227860(+) A-I      intronic chr4:184049607(+) A-I      intronic chr4:184213554(+) A-I      intronic chr4:184073513(+) A-I      intronic chr4:184218167(+) A-I      intronic chr4:184218155(+) A-I      intronic chr4:184217832(+) A-I      intronic chr4:184075058(+) A-I      intronic chr4:184049160(+) A-I      intronic chr4:184213572(+) A-I      intronic chr4:184132450(+) A-I      intronic chr4:184049413(+) A-I      intronic chr4:184193100(+) A-I      intronic chr4:184217940(+) A-I      intronic chr4:184214247(+) A-I      intronic chr4:184211589(+) A-I      intronic chr4:184049412(+) A-I      intronic chr4:184152562(+) A-I      intronic chr4:184218205(+) A-I      intronic chr4:184027207(+) A-I      intronic chr4:184151598(+) A-I      intronic chr4:184109530(+) A-I      intronic chr4:184049371(+) A-I      intronic chr4:184152685(+) A-I      intronic chr4:184045882(+) A-I      intronic chr4:184109571(+) A-I      intronic chr4:184074979(+) A-I      intronic chr4:184147389(+) A-I      intronic chr4:184217885(+) A-I      intronic chr4:184034785(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WWC2	chr4:184020467-184020468(+) m6A 5'UTR       24209618//25456834 chr4:184020705-184020706(+) m6A CDS       24284625 chr4:184124726-184124727(+) m6A 5'UTR//intron       24981863 chr4:184129107-184129108(+) m6A 5'UTR//CDS//intron       24981863 chr4:184129133-184129134(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863 chr4:184129148-184129149(+) m6A 5'UTR//CDS//intron       24284625//24209618//24981863 chr4:184129168-184129169(+) m6A CDS//intron       24284625//24209618//24981863 chr4:184129200-184129201(+) m6A CDS//intron       24284625//24209618//24981863 chr4:184129211-184129212(+) m6A CDS//intron       24284625//24209618//24981863 chr4:184161376-184161377(+) m6A 3'UTR//CDS//intron       24981863 chr4:184161391-184161392(+) m6A 3'UTR//CDS//intron       24981863 chr4:184161404-184161405(+) m6A 3'UTR//CDS//intron       24981863 chr4:184174930-184174931(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184174944-184174945(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184174987-184174988(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184175014-184175015(+) m6A 3'UTR//CDS       24981863//27773535 chr4:184175126-184175127(+) m6A 3'UTR//CDS       24981863 chr4:184175155-184175156(+) Tm intron       - chr4:184180830-184180831(+) m6A 3'UTR//CDS       24209618//24981863 chr4:184180840-184180841(+) m6A 3'UTR//CDS       24284625//24209618//24981863 chr4:184182136-184182137(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr4:184182179-184182180(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr4:184182230-184182231(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182235-184182236(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182275-184182276(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182338-184182339(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:184182535-184182536(+) m6A 3'UTR//CDS       24284625//24981863 chr4:184182640-184182641(+) m6A 3'UTR//CDS//intron       24284625//24981863 chr4:184201981-184201982(+) m6A 3'UTR//CDS//exon       24981863 chr4:184202017-184202018(+) m6A 3'UTR//CDS//exon       24981863 chr4:184202046-184202047(+) m6A 3'UTR//CDS//exon       24981863 chr4:184202055-184202056(+) m6A CDS//exon//intron       24981863 chr4:184202116-184202117(+) m6A CDS//exon//intron       24981863 chr4:184203931-184203932(+) m6A 3'UTR//CDS       24981863 chr4:184203994-184203995(+) m6A 3'UTR//CDS       24981863 chr4:184204021-184204022(+) m6A 3'UTR//CDS       24981863 chr4:184205390-184205391(+) m6A 3'UTR//CDS       24981863 chr4:184205544-184205545(+) Tm intron       - chr4:184210596-184210597(+) m6A 3'UTR//CDS       25456834 chr4:184210606-184210607(+) m6A 3'UTR//CDS       25456834 chr4:184210613-184210614(+) m6A 3'UTR//CDS       25456834 chr4:184210618-184210619(+) m6A 3'UTR//CDS       25456834 chr4:184210678-184210679(+) m6A 3'UTR//CDS       24284625//24209618//25456834 chr4:184210700-184210701(+) m6A 3'UTR//CDS       24284625//24209618//25456834 chr4:184210719-184210720(+) m6A 3'UTR//CDS       24284625//24209618//25456834 chr4:184233498-184233499(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863 chr4:184236939-184236940(+) m6A 3'UTR       24981863//22608085 chr4:184237007-184237008(+) m6A 3'UTR       24981863 chr4:184237155-184237156(+) m6A 3'UTR       24981863 chr4:184237232-184237233(+) Y 3'UTR       26075521 chr4:184237486-184237487(+) m6A 3'UTR       24981863 chr4:184237498-184237499(+) m6A 3'UTR       24981863 chr4:184237610-184237611(+) m6A 3'UTR       24209618//24981863 chr4:184240887-184240888(+) m6A 3'UTR       25456834 chr4:184240901-184240902(+) m6A 3'UTR       25456834 chr4:184240929-184240930(+) m6A 3'UTR       25456834 chr4:184240937-184240938(+) m6A 3'UTR       25456834 chr4:184240967-184240968(+) m6A 3'UTR       25456834 chr4:184240995-184240996(+) m6A 3'UTR       25456834 chr4:184241059-184241060(+) m6A 3'UTR       25456834 chr4:184241296-184241297(+) m6A 3'UTR       24981863 chr4:184241306-184241307(+) m6A 3'UTR       24981863 chr4:184241330-184241331(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26a-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	WWC2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26a-1-3p
Interactor2: WWC2

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.