Detail Information

Basic Information:


  VIRBase ID:  

HHID00098970

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-1-3p:           PLEKHA3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-26a-1-3p PLEKHA3
miRBase
Accession/Entrez ID		 MIMAT0004499 65977
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FAPP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-26a-1-3p
rs182070256 chr3:37969473    G/A
rs771522629 chr3:37969472    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLEKHA3
chr2:179345219-179345220(+) m6A 5'UTR       25456834//24981863
chr2:179360328-179360329(+) Y 3'UTR//CDS       26075521
chr2:179365813-179365814(+) Y CDS       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-26a-1-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
PLEKHA3
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-26a-1-3p
Interactor2: PLEKHA3

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Upregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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