Basic Information:

  VIRBase ID:  

HHID00098969

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-1-3p:  MIMAT0004499          PLEKHA1:  NM_001377247     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26a-1-3p	PLEKHA1
miRBase Accession/Entrez ID	MIMAT0004499	59338
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	TAPP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26a-1-3p	rs182070256 chr3:37969473    G/A rs771522629 chr3:37969472    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLEKHA1	chr10:124190740(+) A-I      3'UTR chr10:124190738(+) A-I      3'UTR chr10:124190737(+) A-I      3'UTR chr10:124190766(+) A-I      3'UTR chr10:124190776(+) A-I      3'UTR chr10:124190770(+) A-I      3'UTR chr10:124166494(+) A-I      intronic chr10:124177085(+) A-I      intronic chr10:124144365(+) A-I      intronic chr10:124159300(+) A-I      intronic chr10:124159286(+) A-I      intronic chr10:124144938(+) A-I      intronic chr10:124144374(+) A-I      intronic chr10:124142905(+) A-I      intronic chr10:124144999(+) A-I      intronic chr10:124144937(+) A-I      intronic chr10:124144311(+) A-I      intronic chr10:124179534(+) A-I      ncRNA chr10:124185117(+) A-I      ncRNA chr10:124144075(+) A-I      intronic chr10:124144951(+) A-I      intronic chr10:124145015(+) A-I      intronic chr10:124144392(+) A-I      intronic chr10:124144305(+) A-I      intronic chr10:124144998(+) A-I      intronic chr10:124142872(+) A-I      intronic chr10:124144259(+) A-I      intronic chr10:124142899(+) A-I      intronic chr10:124144973(+) A-I      intronic chr10:124138141(+) A-I      intronic chr10:124144978(+) A-I      intronic chr10:124144352(+) A-I      intronic chr10:124144934(+) A-I      intronic chr10:124144207(+) A-I      intronic chr10:124142975(+) A-I      intronic chr10:124144384(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLEKHA1	chr10:124175460-124175461(+) m6A CDS//exon       27773535 chr10:124189168-124189169(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr10:124189302-124189303(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189316-124189317(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189333-124189334(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189354-124189355(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189369-124189370(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189416-124189417(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:124189596-124189597(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26a-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	PLEKHA1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26a-1-3p
Interactor2: PLEKHA1

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.