Basic Information:

  VIRBase ID:  

HHID00098959

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-1-3p:  MIMAT0004499          USP8:  NM_005154     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-26a-1-3p	USP8
miRBase Accession/Entrez ID	MIMAT0004499	9101
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HumORF8//PITA4//SPG59//UBPY

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-26a-1-3p	rs182070256 chr3:37969473    G/A rs771522629 chr3:37969472    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	USP8	chr15:50737980(+) A-I      intronic chr15:50764957(+) A-I      intronic chr15:50764948(+) A-I      intronic chr15:50749897(+) A-I      intronic chr15:50737975(+) A-I      intronic chr15:50749919(+) A-I      intronic chr15:50787759(+) A-I      intronic chr15:50787773(+) A-I      intronic chr15:50737612(+) A-I      intronic chr15:50737572(+) A-I      intronic chr15:50764898(+) A-I      intronic chr15:50786997(+) A-I      intronic chr15:50734787(+) A-I      intronic chr15:50734782(+) A-I      intronic chr15:50734780(+) A-I      intronic chr15:50734764(+) A-I      intronic chr15:50734755(+) A-I      intronic chr15:50734754(+) A-I      intronic chr15:50734731(+) A-I      intronic chr15:50734792(+) A-I      intronic chr15:50734791(+) A-I      intronic chr15:50764129(+) A-I      intronic chr15:50735712(+) A-I      intronic chr15:50735699(+) A-I      intronic chr15:50734827(+) A-I      intronic chr15:50734795(+) A-I      intronic chr15:50734699(+) A-I      intronic chr15:50772193(+) A-I      intronic chr15:50734275(+) A-I      intronic chr15:50767880(+) A-I      intronic chr15:50734272(+) A-I      intronic chr15:50734271(+) A-I      intronic chr15:50753943(+) A-I      intronic chr15:50734240(+) A-I      intronic chr15:50764360(+) A-I      intronic chr15:50730531(+) A-I      intronic chr15:50727037(+) A-I      intronic chr15:50753916(+) A-I      intronic chr15:50726998(+) A-I      intronic chr15:50753891(+) A-I      intronic chr15:50725184(+) A-I      intronic chr15:50747326(+) A-I      intronic chr15:50753889(+) A-I      intronic chr15:50736979(+) A-I      intronic chr15:50753259(+) A-I      intronic chr15:50732138(+) A-I      intronic chr15:50737582(+) A-I      intronic chr15:50737934(+) A-I      intronic chr15:50737999(+) A-I      intronic chr15:50753885(+) A-I      intronic chr15:50768061(+) A-I      intronic chr15:50759956(+) A-I      intronic chr15:50725376(+) A-I      intronic chr15:50750524(+) A-I      intronic chr15:50753307(+) A-I      intronic chr15:50750515(+) A-I      intronic chr15:50750485(+) A-I      intronic chr15:50750540(+) A-I      intronic chr15:50738982(+) A-I      intronic chr15:50747304(+) A-I      intronic chr15:50750621(+) A-I      intronic chr15:50750478(+) A-I      intronic chr15:50764629(+) A-I      intronic chr15:50753849(+) A-I      intronic chr15:50749970(+) A-I      intronic chr15:50772025(+) A-I      intronic chr15:50746778(+) A-I      intronic chr15:50746739(+) A-I      intronic chr15:50753835(+) A-I      intronic chr15:50741985(+) A-I      intronic chr15:50753780(+) A-I      intronic chr15:50764679(+) A-I      intronic chr15:50764700(+) A-I      intronic chr15:50764906(+) A-I      intronic chr15:50762259(+) A-I      intronic chr15:50734887(+) A-I      intronic chr15:50764191(+) A-I      intronic chr15:50747391(+) A-I      intronic chr15:50747525(+) A-I      intronic chr15:50748514(+) A-I      intronic chr15:50753372(+) A-I      intronic chr15:50748519(+) A-I      intronic chr15:50748565(+) A-I      intronic chr15:50753361(+) A-I      intronic chr15:50748576(+) A-I      intronic chr15:50753293(+) A-I      intronic chr15:50747543(+) A-I      intronic chr15:50753335(+) A-I      intronic chr15:50788606(+) A-I      intronic chr15:50737950(+) A-I      intronic chr15:50765056(+) A-I      intronic chr15:50753270(+) A-I      intronic chr15:50784244(+) A-I      intronic chr15:50765062(+) A-I      intronic chr15:50748751(+) A-I      intronic chr15:50747522(+) A-I      intronic chr15:50735335(+) A-I      intronic chr15:50764870(+) A-I      intronic chr15:50767929(+) A-I      intronic chr15:50780897(+) A-I      intronic chr15:50725319(+) A-I      intronic chr15:50762219(+) A-I      intronic chr15:50739583(+) A-I      intronic chr15:50748585(+) A-I      intronic chr15:50749004(+) A-I      intronic chr15:50739577(+) A-I      intronic chr15:50725318(+) A-I      intronic chr15:50739555(+) A-I      intronic chr15:50760620(+) A-I      intronic chr15:50737616(+) A-I      intronic chr15:50749033(+) A-I      intronic chr15:50749048(+) A-I      intronic chr15:50760576(+) A-I      intronic chr15:50749590(+) A-I      intronic chr15:50749500(+) A-I      intronic chr15:50730721(+) A-I      intronic chr15:50749499(+) A-I      intronic chr15:50739090(+) A-I      intronic chr15:50764142(+) A-I      intronic chr15:50749604(+) A-I      intronic chr15:50749634(+) A-I      intronic chr15:50718143(+) A-I      intronic chr15:50718158(+) A-I      intronic chr15:50718308(+) A-I      intronic chr15:50749762(+) A-I      intronic chr15:50764609(+) A-I      intronic chr15:50756863(+) A-I      intronic chr15:50721813(+) A-I      intronic chr15:50749802(+) A-I      intronic chr15:50764272(+) A-I      intronic chr15:50758733(+) A-I      intronic chr15:50743427(+) A-I      intronic chr15:50721824(+) A-I      intronic chr15:50723953(+) A-I      intronic chr15:50725243(+) A-I      intronic chr15:50749915(+) A-I      intronic chr15:50758612(+) A-I      intronic chr15:50726966(+) A-I      intronic chr15:50748703(+) A-I      intronic chr15:50764146(+) A-I      intronic chr15:50739088(+) A-I      intronic chr15:50725263(+) A-I      intronic chr15:50726574(+) A-I      intronic chr15:50766271(+) A-I      intronic chr15:50749964(+) A-I      intronic chr15:50766174(+) A-I      intronic chr15:50747465(+) A-I      intronic chr15:50739013(+) A-I      intronic chr15:50766397(+) A-I      intronic chr15:50737933(+) A-I      intronic chr15:50737785(+) A-I      intronic chr15:50740156(+) A-I      intronic chr15:50739012(+) A-I      intronic chr15:50738994(+) A-I      intronic chr15:50753794(+) A-I      intronic chr15:50726534(+) A-I      intronic chr15:50767044(+) A-I      intronic chr15:50767086(+) A-I      intronic chr15:50737960(+) A-I      intronic chr15:50737923(+) A-I      intronic chr15:50737911(+) A-I      intronic chr15:50737876(+) A-I      intronic chr15:50737861(+) A-I      intronic chr15:50726568(+) A-I      intronic chr15:50753245(+) A-I      intronic chr15:50749973(+) A-I      intronic chr15:50737837(+) A-I      intronic chr15:50737832(+) A-I      intronic chr15:50767122(+) A-I      intronic chr15:50750045(+) A-I      intronic chr15:50767156(+) A-I      intronic chr15:50767167(+) A-I      intronic chr15:50737820(+) A-I      intronic chr15:50767215(+) A-I      intronic chr15:50750448(+) A-I      intronic chr15:50725380(+) A-I      intronic chr15:50758672(+) A-I      intronic chr15:50749911(+) A-I      intronic chr15:50764673(+) A-I      intronic chr15:50767231(+) A-I      intronic chr15:50767263(+) A-I      intronic chr15:50748491(+) A-I      intronic chr15:50767864(+) A-I      intronic chr15:50749608(+) A-I      intronic chr15:50768545(+) A-I      intronic chr15:50768560(+) A-I      intronic chr15:50737664(+) A-I      intronic chr15:50764986(+) A-I      intronic chr15:50772035(+) A-I      intronic chr15:50780842(+) A-I      intronic chr15:50772192(+) A-I      intronic chr15:50778569(+) A-I      intronic chr15:50765766(+) A-I      intronic chr15:50778573(+) A-I      intronic chr15:50778599(+) A-I      intronic chr15:50737663(+) A-I      intronic chr15:50778604(+) A-I      intronic chr15:50737581(+) A-I      intronic chr15:50780887(+) A-I      intronic chr15:50737565(+) A-I      intronic chr15:50737533(+) A-I      intronic chr15:50737487(+) A-I      intronic chr15:50737100(+) A-I      intronic chr15:50737096(+) A-I      intronic chr15:50737067(+) A-I      intronic chr15:50725274(+) A-I      intronic chr15:50725288(+) A-I      intronic chr15:50737054(+) A-I      intronic chr15:50735739(+) A-I      intronic chr15:50735726(+) A-I      intronic chr15:50764647(+) A-I      intronic chr15:50718197(+) A-I      intronic chr15:50737863(+) A-I      intronic chr15:50730702(+) A-I      intronic chr15:50750466(+) A-I      intronic chr15:50764956(+) A-I      intronic chr15:50718306(+) A-I      intronic chr15:50750413(+) A-I      intronic chr15:50780621(+) A-I      intronic chr15:50735702(+) A-I      intronic chr15:50743334(+) A-I      intronic chr15:50750609(+) A-I      intronic chr15:50750570(+) A-I      intronic chr15:50726953(+) A-I      intronic chr15:50718154(+) A-I      intronic chr15:50737169(+) A-I      intronic chr15:50736395(+) A-I      intronic chr15:50780714(+) A-I      intronic chr15:50749992(+) A-I      intronic chr15:50743327(+) A-I      intronic chr15:50765879(+) A-I      intronic chr15:50751634(+) A-I      intronic chr15:50753539(+) A-I      intronic chr15:50764960(+) A-I      intronic chr15:50766462(+) A-I      intronic chr15:50735375(+) A-I      intronic chr15:50759937(+) A-I      intronic chr15:50753868(+) A-I      intronic chr15:50787789(+) A-I      intronic chr15:50742722(+) A-I      intronic chr15:50767154(+) A-I      intronic chr15:50767248(+) A-I      intronic chr15:50764281(+) A-I      intronic chr15:50737903(+) A-I      intronic chr15:50762978(+) A-I      intronic chr15:50764215(+) A-I      intronic chr15:50748923(+) A-I      intronic chr15:50766390(+) A-I      intronic chr15:50764227(+) A-I      intronic chr15:50762129(+) A-I      intronic chr15:50765028(+) A-I      intronic chr15:50730526(+) A-I      intronic chr15:50764987(+) A-I      intronic chr15:50759817(+) A-I      intronic chr15:50759975(+) A-I      intronic chr15:50765841(+) A-I      intronic chr15:50762122(+) A-I      intronic chr15:50767939(+) A-I      intronic chr15:50723909(+) A-I      intronic chr15:50749687(+) A-I      intronic chr15:50753379(+) A-I      intronic chr15:50760661(+) A-I      intronic chr15:50768598(+) A-I      intronic chr15:50768553(+) A-I      intronic chr15:50767824(+) A-I      intronic chr15:50762265(+) A-I      intronic chr15:50727085(+) A-I      intronic chr15:50740001(+) A-I      intronic chr15:50737974(+) A-I      intronic chr15:50765835(+) A-I      intronic chr15:50738986(+) A-I      intronic chr15:50746189(+) A-I      intronic chr15:50750548(+) A-I      intronic chr15:50725183(+) A-I      intronic chr15:50735820(+) A-I      intronic chr15:50750610(+) A-I      intronic chr15:50787075(+) A-I      intronic chr15:50766452(+) A-I      intronic chr15:50787776(+) A-I      intronic chr15:50734821(+) A-I      intronic chr15:50719319(+) A-I      intronic chr15:50766301(+) A-I      intronic chr15:50753319(+) A-I      intronic chr15:50722489(+) A-I      intronic chr15:50781135(+) A-I      intronic chr15:50750584(+) A-I      intronic chr15:50753874(+) A-I      intronic chr15:50787734(+) A-I      intronic chr15:50778495(+) A-I      intronic chr15:50760579(+) A-I      intronic chr15:50758797(+) A-I      intronic chr15:50779200(+) A-I      intronic chr15:50765003(+) A-I      intronic chr15:50750474(+) A-I      intronic chr15:50766474(+) A-I      intronic chr15:50718048(+) A-I      intronic chr15:50718157(+) A-I      intronic chr15:50746835(+) A-I      intronic chr15:50762170(+) A-I      intronic chr15:50781044(+) A-I      intronic chr15:50753648(+) A-I      intronic chr15:50726439(+) A-I      intronic chr15:50749011(+) A-I      intronic chr15:50727051(+) A-I      intronic chr15:50750587(+) A-I      intronic chr15:50750380(+) A-I      intronic chr15:50734405(+) A-I      intronic chr15:50767238(+) A-I      intronic chr15:50768552(+) A-I      intronic chr15:50766095(+) A-I      intronic chr15:50753276(+) A-I      intronic chr15:50737596(+) A-I      intronic chr15:50764278(+) A-I      intronic chr15:50746159(+) A-I      intronic chr15:50733088(+) A-I      intronic chr15:50762194(+) A-I      intronic chr15:50758669(+) A-I      intronic chr15:50719316(+) A-I      intronic chr15:50758558(+) A-I      intronic chr15:50765064(+) A-I      intronic chr15:50755254(+) A-I      intronic chr15:50781098(+) A-I      intronic chr15:50747486(+) A-I      intronic chr15:50768547(+) A-I      intronic chr15:50759822(+) A-I      intronic chr15:50748921(+) A-I      intronic chr15:50765057(+) A-I      intronic chr15:50734822(+) A-I      intronic chr15:50758744(+) A-I      intronic chr15:50764893(+) A-I      intronic chr15:50743461(+) A-I      intronic chr15:50768523(+) A-I      intronic chr15:50723993(+) A-I      intronic chr15:50767227(+) A-I      intronic chr15:50735261(+) A-I      intronic chr15:50766422(+) A-I      intronic chr15:50768516(+) A-I      intronic chr15:50778563(+) A-I      intronic chr15:50726836(+) A-I      intronic chr15:50772056(+) A-I      intronic chr15:50766162(+) A-I      intronic chr15:50735340(+) A-I      intronic chr15:50787709(+) A-I      intronic chr15:50719333(+) A-I      intronic chr15:50765016(+) A-I      intronic chr15:50742769(+) A-I      intronic chr15:50764151(+) A-I      intronic chr15:50765886(+) A-I      intronic chr15:50742725(+) A-I      intronic chr15:50767830(+) A-I      intronic chr15:50735322(+) A-I      intronic chr15:50737943(+) A-I      intronic chr15:50743350(+) A-I      intronic chr15:50767925(+) A-I      intronic chr15:50749951(+) A-I      intronic chr15:50743540(+) A-I      intronic chr15:50737622(+) A-I      intronic chr15:50749760(+) A-I      intronic chr15:50765019(+) A-I      intronic chr15:50725351(+) A-I      intronic chr15:50765943(+) A-I      intronic chr15:50762084(+) A-I      intronic chr15:50725291(+) A-I      intronic chr15:50758671(+) A-I      intronic chr15:50725229(+) A-I      intronic chr15:50734874(+) A-I      intronic chr15:50765000(+) A-I      intronic chr15:50765910(+) A-I      intronic chr15:50743341(+) A-I      intronic chr15:50749899(+) A-I      intronic chr15:50743419(+) A-I      intronic chr15:50760623(+) A-I      intronic chr15:50750004(+) A-I      intronic chr15:50719220(+) A-I      intronic chr15:50750408(+) A-I      intronic chr15:50734857(+) A-I      intronic chr15:50753315(+) A-I      intronic chr15:50750449(+) A-I      intronic chr15:50737907(+) A-I      intronic chr15:50753283(+) A-I      intronic chr15:50734391(+) A-I      intronic chr15:50767199(+) A-I      intronic chr15:50753575(+) A-I      intronic chr15:50780891(+) A-I      intronic chr15:50749864(+) A-I      intronic chr15:50775788(+) A-I      intronic chr15:50735336(+) A-I      intronic chr15:50720210(+) A-I      intronic chr15:50780167(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	USP8	chr15:50759822(+) A-G intron -    22484847 chr15:50764956(+) A-G intron -    22484847 chr15:50764986(+) A-G intron -    22484847 chr15:50764987(+) A-G intron -    22484847 chr15:50765028(+) A-G intron -    22484847 chr15:50767154(+) A-G intron -    22484847 chr15:50767929(+) A-G intron -    22484847 chr15:50768516(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	USP8	chr15:50731299-50731300(+) m6A CDS//exon//intron       24981863 chr15:50731325-50731326(+) m6A CDS//exon//intron       24981863 chr15:50731339-50731340(+) m6A CDS//exon//intron       24981863 chr15:50731350-50731351(+) m6A CDS//exon//intron       24981863//27773535 chr15:50733576-50733577(+) m6A CDS//exon//intron       24981863//27773535 chr15:50733668-50733669(+) m6A CDS//exon//intron       24981863 chr15:50741619-50741620(+) m6A CDS//exon//intron       24981863 chr15:50741627-50741628(+) m6A CDS//exon//intron       24981863 chr15:50741658-50741659(+) m6A CDS//exon//intron       24981863 chr15:50741679-50741680(+) Am CDS//exon//intron       - chr15:50750774-50750775(+) m6A exon//intron       24981863//27773535 chr15:50751223-50751224(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085 chr15:50751237-50751238(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085 chr15:50751281-50751282(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085 chr15:50751345-50751346(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085 chr15:50751350-50751351(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085 chr15:50754506-50754507(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085 chr15:50757262-50757263(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085 chr15:50757288-50757289(+) m6A 3'UTR//CDS//exon//intron       24981863 chr15:50773694-50773695(+) m6A 3'UTR//CDS       24981863 chr15:50773744-50773745(+) m6A 3'UTR//CDS       24981863//27773535 chr15:50773863-50773864(+) m6A 3'UTR//CDS       25456834//24981863//27773535//22608085 chr15:50773885-50773886(+) m6A 3'UTR//CDS       25456834//24981863//27773535//27371828//22608085 chr15:50773901-50773902(+) m6A 3'UTR//CDS       25456834//24981863//27773535//27371828//22608085 chr15:50773925-50773926(+) m6A CDS       25456834//24981863//27773535//27371828//22608085 chr15:50773937-50773938(+) m6A CDS       25456834//24981863//27773535//27371828//22608085 chr15:50773952-50773953(+) m6A CDS       25456834//24981863//27773535//27371828//22608085 chr15:50773958-50773959(+) m6A CDS       25456834//24981863//27773535//27371828//22608085 chr15:50773976-50773977(+) m6A CDS       25456834//24981863//27773535//27371828//22608085 chr15:50774051-50774052(+) m6A CDS       25456834//24981863//27773535//22608085 chr15:50774076-50774077(+) m6A CDS       24209618//25456834//24981863//27773535//22608085 chr15:50774117-50774118(+) m6A CDS       24209618//24981863//27773535//22608085 chr15:50774132-50774133(+) m6A CDS       24209618//24981863//27773535//22608085 chr15:50774139-50774140(+) m6A CDS       24209618//24981863//27773535//22608085 chr15:50776488-50776489(+) m6A CDS//intron       24981863//27773535//22608085 chr15:50776513-50776514(+) m6A CDS//intron       24981863//27773535 chr15:50776519-50776520(+) m6A CDS//intron       24981863//27773535 chr15:50781721-50781722(+) m6A exon//intron       24981863 chr15:50782056-50782057(+) m6A CDS//exon       24209618 chr15:50782480-50782481(+) m6A CDS//exon       24209618//24981863 chr15:50782614-50782615(+) m6A CDS//exon       24284625//24981863 chr15:50782623-50782624(+) m6A CDS//exon       24284625//24981863 chr15:50782718-50782719(+) m6A CDS       24284625 chr15:50784953-50784954(+) m6A CDS       24284625//24981863//22608085 chr15:50784981-50784982(+) m6A CDS       24284625//24981863//22608085 chr15:50784996-50784997(+) m6A CDS       24284625//24981863//22608085 chr15:50785028-50785029(+) m6A CDS       24284625//24981863//22608085 chr15:50785085-50785086(+) m6A CDS       24284625//24981863//22608085 chr15:50786333-50786334(+) m6A CDS//exon       24981863//22608085 chr15:50786338-50786339(+) m6A CDS//exon       24981863//22608085 chr15:50786364-50786365(+) m6A CDS//exon       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-26a-1-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	USP8	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-26a-1-3p
Interactor2: USP8

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.