Detail Information

Basic Information:


  VIRBase ID:  

HHID00098955

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-26a-1-3p:           MAN1A1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-26a-1-3p MAN1A1
miRBase
Accession/Entrez ID		 MIMAT0004499 4121
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HUMM3//HUMM9//MAN9

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-26a-1-3p
rs182070256 chr3:37969473    G/A
rs771522629 chr3:37969472    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAN1A1
chr6:119586349(-) A-I      intronic
chr6:119586323(-) A-I      intronic
chr6:119598795(-) A-I      intronic
chr6:119598770(-) A-I      intronic
chr6:119592915(-) A-I      intronic
chr6:119600164(-) A-I      intronic
chr6:119600162(-) A-I      intronic
chr6:119600140(-) A-I      intronic
chr6:119592885(-) A-I      intronic
chr6:119592882(-) A-I      intronic
chr6:119592874(-) A-I      intronic
chr6:119592873(-) A-I      intronic
chr6:119592872(-) A-I      intronic
chr6:119591044(-) A-I      intronic
chr6:119588904(-) A-I      intronic
chr6:119591043(-) A-I      intronic
chr6:119591030(-) A-I      intronic
chr6:119591022(-) A-I      intronic
chr6:119591021(-) A-I      intronic
chr6:119590997(-) A-I      intronic
chr6:119586377(-) A-I      intronic
chr6:119586358(-) A-I      intronic
chr6:119586344(-) A-I      intronic
chr6:119586342(-) A-I      intronic
chr6:119586313(-) A-I      intronic
chr6:119557156(-) A-I      intronic
chr6:119557137(-) A-I      intronic
chr6:119527681(-) A-I      intronic
chr6:119657399(-) A-I      intronic
chr6:119657414(-) A-I      intronic
chr6:119657417(-) A-I      intronic
chr6:119657428(-) A-I      intronic
chr6:119657454(-) A-I      intronic
chr6:119646739(-) A-I      intronic
chr6:119519443(-) A-I      intronic
chr6:119518391(-) A-I      intronic
chr6:119599278(-) A-I      intronic
chr6:119599275(-) A-I      intronic
chr6:119599002(-) A-I      intronic
chr6:119598990(-) A-I      intronic
chr6:119598911(-) A-I      intronic
chr6:119598896(-) A-I      intronic
chr6:119598807(-) A-I      intronic
chr6:119555760(-) A-I      intronic
chr6:119555759(-) A-I      intronic
chr6:119542642(-) A-I      intronic
chr6:119542636(-) A-I      intronic
chr6:119530234(-) A-I      intronic
chr6:119657405(-) A-I      intronic
chr6:119624434(-) A-I      intronic
chr6:119637573(-) A-I      intronic
chr6:119646593(-) A-I      intronic
chr6:119646635(-) A-I      intronic
chr6:119646722(-) A-I      intronic
chr6:119646759(-) A-I      intronic
chr6:119646769(-) A-I      intronic
chr6:119646807(-) A-I      intronic
chr6:119648693(-) A-I      intronic
chr6:119648737(-) A-I      intronic
chr6:119648743(-) A-I      intronic
chr6:119648749(-) A-I      intronic
chr6:119657306(-) A-I      intronic
chr6:119657327(-) A-I      intronic
chr6:119657337(-) A-I      intronic
chr6:119657346(-) A-I      intronic
chr6:119657350(-) A-I      intronic
chr6:119518365(-) A-I      intronic
chr6:119542811(-) A-I      intronic
chr6:119591025(-) A-I      intronic
chr6:119555776(-) A-I      intronic
chr6:119519469(-) A-I      intronic
chr6:119598736(-) A-I      intronic
chr6:119555717(-) A-I      intronic
chr6:119557797(-) A-I      intronic
chr6:119518436(-) A-I      intronic
chr6:119598814(-) A-I      intronic
chr6:119543691(-) A-I      intronic
chr6:119516045(-) A-I      intronic
chr6:119530148(-) A-I      intronic
chr6:119530152(-) A-I      intronic
chr6:119542812(-) A-I      intronic
chr6:119661083(-) A-I      intronic
chr6:119598742(-) A-I      intronic
chr6:119598937(-) A-I      intronic
chr6:119543781(-) A-I      intronic
chr6:119518217(-) A-I      intronic
chr6:119661059(-) A-I      intronic
chr6:119530237(-) A-I      intronic
chr6:119667105(-) A-I      intronic
chr6:119557182(-) A-I      intronic
chr6:119548087(-) A-I      intronic
chr6:119661174(-) A-I      intronic
chr6:119598912(-) A-I      intronic
chr6:119515688(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MAN1A1
chr6:119501940(-) T-C intron -    22484847
chr6:119519469(-) A-G intron -    22484847
chr6:119530148(-) A-G intron -    22484847
chr6:119530152(-) A-G intron -    22484847
chr6:119530237(-) A-G intron -    22484847
chr6:119548087(-) A-G intron -    22484847
chr6:119555717(-) A-G intron -    22484847
chr6:119555756(-) A-G intron -    22484847
chr6:119557140(-) A-G intron -    22484847
chr6:119557158(-) T-C intron -    22484847
chr6:119557182(-) A-G intron -    22484847
chr6:119557872(-) G-T intron -    22484847
chr6:119591084(-) A-G intron -    22484847
chr6:119598912(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAN1A1
chr6:119500898-119500899(-) m6A 3'UTR       22608085
chr6:119500978-119500979(-) m6A 3'UTR       24981863//22608085
chr6:119510831-119510832(-) m6A CDS       27773535
chr6:119510877-119510878(-) m6A CDS       27773535
chr6:119590309-119590310(-) m6A intron       27773535
chr6:119590317-119590318(-) m6A intron       27773535
chr6:119590340-119590341(-) m6A intron       27773535
chr6:119590368-119590369(-) m6A intron       27773535
chr6:119590733-119590734(-) m6A intron       27773535
chr6:119628097-119628098(-) m6A CDS       27773535
chr6:119628103-119628104(-) m6A CDS       25456834//27773535//22608085
chr6:119628148-119628149(-) m6A CDS       24284625//24209618//25456834//28052920//27773535//27371828//22608085
chr6:119669706-119669707(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:119669751-119669752(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:119669767-119669768(-) m1A CDS       26863196
chr6:119669784-119669785(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:119669818-119669819(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr6:119669850-119669851(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr6:119669874-119669875(-) m6A CDS       24284625//24209618//25456834//27773535//27371828//27773536//22608085
chr6:119669895-119669896(-) m6A CDS       24284625//24209618//25456834//27773535//27371828//27773536//22608085
chr6:119670039-119670040(-) m6A CDS       24284625//24209618//27773535//27773536
chr6:119670241-119670242(-) m6A 5'UTR       24209618//25456834//27371828//27773536//22575960//22608085
chr6:119670249-119670250(-) m6A 5'UTR       24209618//25456834//27371828//27773536//22575960//22608085
chr6:119670295-119670296(-) m6A 5'UTR       24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr6:119670315-119670316(-) m6A 5'UTR       24284625//24209618//25456834//27371828//27773536//22575960//22608085
chr6:119670389-119670390(-) m6A 5'UTR       24284625//24209618//27371828//27773536//22575960//22608085
chr6:119670814-119670815(-) m6A 5'UTR       27371828//27773536
chr6:119670822-119670823(-) m6A 5'UTR       27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-26a-1-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
MAN1A1
Chromatin HCC cell line (HepG2)|K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleolus HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-26a-1-3p
Interactor2: MAN1A1

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Upregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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