Basic Information:

  VIRBase ID:  

HHID00098950

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          LRRK2:  NM_198578     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	LRRK2
miRBase Accession/Entrez ID	MIMAT0004489	120892
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AURA17//DARDARIN//PARK8//RIPK7//ROCO2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LRRK2	chr12:40629090(+) A-I      intronic chr12:40629119(+) A-I      intronic chr12:40629095(+) A-I      intronic chr12:40629143(+) A-I      intronic chr12:40629162(+) A-I      intronic chr12:40629163(+) A-I      intronic chr12:40629081(+) A-I      intronic chr12:40625250(+) A-I      intronic chr12:40625246(+) A-I      intronic chr12:40625240(+) A-I      intronic chr12:40625214(+) A-I      intronic chr12:40629044(+) A-I      intronic chr12:40664771(+) A-I      intronic chr12:40629039(+) A-I      intronic chr12:40629024(+) A-I      intronic chr12:40629019(+) A-I      intronic chr12:40720018(+) A-I      intronic chr12:40720290(+) A-I      intronic chr12:40629016(+) A-I      intronic chr12:40720278(+) A-I      intronic chr12:40629159(+) A-I      intronic chr12:40629153(+) A-I      intronic chr12:40625280(+) A-I      intronic chr12:40658167(+) A-I      intronic chr12:40621631(+) A-I      intronic chr12:40629127(+) A-I      intronic chr12:40621691(+) A-I      intronic chr12:40625100(+) A-I      intronic chr12:40674089(+) A-I      intronic chr12:40621640(+) A-I      intronic chr12:40727525(+) A-I      intronic chr12:40625723(+) A-I      intronic chr12:40625121(+) A-I      intronic chr12:40625318(+) A-I      intronic chr12:40629167(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LRRK2	chr12:40625100(+) A-G intron -    22484847 chr12:40625121(+) A-G intron -    22484847 chr12:40629167(+) A-G intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	LRRK2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: LRRK2

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.