Basic Information:

  VIRBase ID:  

HHID00098946

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          PTBP2:  NM_001300988     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	PTBP2
miRBase Accession/Entrez ID	MIMAT0004489	58155
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	brPTB//nPTB//PTBLP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PTBP2	chr1:97210905(+) A-I      intronic chr1:97266135(+) A-I      intronic chr1:97266137(+) A-I      intronic chr1:97210903(+) A-I      intronic chr1:97240232(+) A-I      intronic chr1:97191481(+) A-I      intronic chr1:97263544(+) A-I      intronic chr1:97263560(+) A-I      intronic chr1:97263582(+) A-I      intronic chr1:97263761(+) A-I      intronic chr1:97266129(+) A-I      intronic chr1:97266133(+) A-I      intronic chr1:97266159(+) A-I      intronic chr1:97266147(+) A-I      intronic chr1:97257600(+) A-I      intronic chr1:97210855(+) A-I      intronic chr1:97190930(+) A-I      intronic chr1:97190955(+) A-I      intronic chr1:97190995(+) A-I      intronic chr1:97211543(+) A-I      intronic chr1:97264969(+) A-I      intronic chr1:97191476(+) A-I      intronic chr1:97264933(+) A-I      intronic chr1:97264871(+) A-I      intronic chr1:97263917(+) A-I      intronic chr1:97263914(+) A-I      intronic chr1:97264956(+) A-I      intronic chr1:97191527(+) A-I      intronic chr1:97191537(+) A-I      intronic chr1:97191572(+) A-I      intronic chr1:97191588(+) A-I      intronic chr1:97192255(+) A-I      intronic chr1:97209594(+) A-I      intronic chr1:97209595(+) A-I      intronic chr1:97263903(+) A-I      intronic chr1:97263883(+) A-I      intronic chr1:97209616(+) A-I      intronic chr1:97263871(+) A-I      intronic chr1:97211511(+) A-I      intronic chr1:97263851(+) A-I      intronic chr1:97263819(+) A-I      intronic chr1:97267722(+) A-I      intronic chr1:97211547(+) A-I      intronic chr1:97226081(+) A-I      intronic chr1:97265018(+) A-I      intronic chr1:97226082(+) A-I      intronic chr1:97226101(+) A-I      intronic chr1:97231186(+) A-I      intronic chr1:97263766(+) A-I      intronic chr1:97263762(+) A-I      intronic chr1:97231213(+) A-I      intronic chr1:97231216(+) A-I      intronic chr1:97257411(+) A-I      intronic chr1:97257494(+) A-I      intronic chr1:97257515(+) A-I      intronic chr1:97257519(+) A-I      intronic chr1:97259043(+) A-I      intronic chr1:97259109(+) A-I      intronic chr1:97263538(+) A-I      intronic chr1:97263545(+) A-I      intronic chr1:97191472(+) A-I      intronic chr1:97191465(+) A-I      intronic chr1:97266098(+) A-I      intronic chr1:97265017(+) A-I      intronic chr1:97265013(+) A-I      intronic chr1:97267695(+) A-I      intronic chr1:97267646(+) A-I      intronic chr1:97267323(+) A-I      intronic chr1:97267270(+) A-I      intronic chr1:97266192(+) A-I      intronic chr1:97266175(+) A-I      intronic chr1:97266138(+) A-I      intronic chr1:97266134(+) A-I      intronic chr1:97266128(+) A-I      intronic chr1:97267673(+) A-I      intronic chr1:97266127(+) A-I      intronic chr1:97266101(+) A-I      intronic chr1:97263511(+) A-I      intronic chr1:97263776(+) A-I      intronic chr1:97259006(+) A-I      intronic chr1:97190973(+) A-I      intronic chr1:97266131(+) A-I      intronic chr1:97263842(+) A-I      intronic chr1:97209624(+) A-I      intronic chr1:97210900(+) A-I      intronic chr1:97258944(+) A-I      intronic chr1:97257531(+) A-I      intronic chr1:97191575(+) A-I      intronic chr1:97192324(+) A-I      intronic chr1:97211389(+) A-I      intronic chr1:97190917(+) A-I      intronic chr1:97266272(+) A-I      intronic chr1:97267156(+) A-I      intronic chr1:97210925(+) A-I      intronic chr1:97259112(+) A-I      intronic chr1:97266239(+) A-I      intronic chr1:97259201(+) A-I      intronic chr1:97263907(+) A-I      intronic chr1:97190985(+) A-I      intronic chr1:97266143(+) A-I      intronic chr1:97266183(+) A-I      intronic chr1:97191576(+) A-I      intronic chr1:97191909(+) A-I      intronic chr1:97263723(+) A-I      intronic chr1:97192321(+) A-I      intronic chr1:97266245(+) A-I      intronic chr1:97191484(+) A-I      intronic chr1:97267338(+) A-I      intronic chr1:97263944(+) A-I      intronic chr1:97263887(+) A-I      intronic chr1:97263809(+) A-I      intronic chr1:97231138(+) A-I      intronic chr1:97211483(+) A-I      intronic chr1:97221858(+) A-I      intronic chr1:97191380(+) A-I      intronic chr1:97264991(+) A-I      intronic chr1:97266102(+) A-I      intronic chr1:97209626(+) A-I      intronic chr1:97263841(+) A-I      intronic chr1:97259116(+) A-I      intronic chr1:97208587(+) A-I      intronic chr1:97266215(+) A-I      intronic chr1:97265034(+) A-I      intronic chr1:97191381(+) A-I      intronic chr1:97208676(+) A-I      intronic chr1:97192413(+) A-I      intronic chr1:97211501(+) A-I      intronic chr1:97264916(+) A-I      intronic chr1:97192068(+) A-I      intronic chr1:97263868(+) A-I      intronic chr1:97265059(+) A-I      intronic chr1:97267405(+) A-I      intronic chr1:97264895(+) A-I      intronic chr1:97191478(+) A-I      intronic chr1:97267306(+) A-I      intronic chr1:97198980(+) A-I      intronic chr1:97191583(+) A-I      intronic chr1:97266179(+) A-I      intronic chr1:97267139(+) A-I      intronic chr1:97264902(+) A-I      intronic chr1:97221756(+) A-I      intronic chr1:97263775(+) A-I      intronic chr1:97267380(+) A-I      intronic chr1:97211475(+) A-I      intronic chr1:97209503(+) A-I      intronic chr1:97191548(+) A-I      intronic chr1:97266140(+) A-I      intronic chr1:97266130(+) A-I      intronic chr1:97267382(+) A-I      intronic chr1:97231156(+) A-I      intronic chr1:97209695(+) A-I      intronic chr1:97211360(+) A-I      intronic chr1:97265028(+) A-I      intronic chr1:97264932(+) A-I      intronic chr1:97264981(+) A-I      intronic chr1:97191037(+) A-I      intronic chr1:97267231(+) A-I      intronic chr1:97208679(+) A-I      intronic chr1:97257575(+) A-I      intronic chr1:97266255(+) A-I      intronic chr1:97257578(+) A-I      intronic chr1:97263932(+) A-I      intronic chr1:97206982(+) A-I      intronic chr1:97191040(+) A-I      intronic chr1:97209588(+) A-I      intronic chr1:97266186(+) A-I      intronic chr1:97211435(+) A-I      intronic chr1:97267296(+) A-I      intronic chr1:97211518(+) A-I      intronic chr1:97191444(+) A-I      intronic chr1:97257529(+) A-I      intronic chr1:97192178(+) A-I      intronic chr1:97191510(+) A-I      intronic chr1:97208659(+) A-I      intronic chr1:97263855(+) A-I      intronic chr1:97209597(+) A-I      intronic chr1:97267241(+) A-I      intronic chr1:97209600(+) A-I      intronic chr1:97252761(+) A-I      intronic chr1:97263802(+) A-I      intronic chr1:97191474(+) A-I      intronic chr1:97267283(+) A-I      intronic chr1:97259134(+) A-I      intronic chr1:97210742(+) A-I      intronic chr1:97267230(+) A-I      intronic chr1:97210758(+) A-I      intronic chr1:97190933(+) A-I      intronic chr1:97191468(+) A-I      intronic chr1:97263815(+) A-I      intronic chr1:97209519(+) A-I      intronic chr1:97263784(+) A-I      intronic chr1:97191431(+) A-I      intronic chr1:97264908(+) A-I      intronic chr1:97267182(+) A-I      intronic chr1:97263707(+) A-I      intronic chr1:97266169(+) A-I      intronic chr1:97191469(+) A-I      intronic chr1:97265037(+) A-I      intronic chr1:97257551(+) A-I      intronic chr1:97209725(+) A-I      intronic chr1:97264926(+) A-I      intronic chr1:97263810(+) A-I      intronic chr1:97200497(+) A-I      intronic chr1:97191903(+) A-I      intronic chr1:97266124(+) A-I      intronic chr1:97211434(+) A-I      intronic chr1:97192270(+) A-I      intronic chr1:97210848(+) A-I      intronic chr1:97191454(+) A-I      intronic chr1:97211515(+) A-I      intronic chr1:97264978(+) A-I      intronic chr1:97191551(+) A-I      intronic chr1:97191958(+) A-I      intronic chr1:97192338(+) A-I      intronic chr1:97211585(+) A-I      intronic chr1:97259055(+) A-I      intronic chr1:97192341(+) A-I      intronic chr1:97266033(+) A-I      intronic chr1:97259065(+) A-I      intronic chr1:97266106(+) A-I      intronic chr1:97252716(+) A-I      intronic chr1:97203959(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PTBP2	chr1:97263776(+) A-I intron -    22327324 chr1:97190973(+) A-G intron -    22484847 chr1:97190985(+) A-G intron -    22484847 chr1:97191037(+) A-G intron -    22484847 chr1:97191040(+) A-G intron -    22484847 chr1:97191381(+) A-G intron -    22484847 chr1:97191468(+) A-G intron -    22484847 chr1:97191510(+) A-G intron -    22484847 chr1:97191576(+) A-G intron -    22484847 chr1:97192068(+) A-G intron -    22484847 chr1:97192178(+) A-G intron -    22484847 chr1:97198980(+) A-G intron -    22484847 chr1:97208659(+) A-G intron -    22484847 chr1:97209624(+) A-G intron -    22484847 chr1:97210848(+) A-G intron -    22484847 chr1:97210925(+) A-G intron -    22484847 chr1:97211360(+) A-G intron -    22484847 chr1:97211389(+) A-G intron -    22484847 chr1:97211434(+) A-G intron -    22484847 chr1:97211435(+) A-G intron -    22484847 chr1:97211475(+) A-G intron -    22484847 chr1:97211483(+) A-G intron -    22484847 chr1:97211515(+) A-G intron -    22484847 chr1:97221858(+) A-G intron -    22484847 chr1:97226098(+) T-C intron -    22484847 chr1:97239365(+) G-A intron -    22484847 chr1:97258944(+) A-G intron -    22484847 chr1:97263511(+) A-G intron -    22484847 chr1:97263775(+) A-G intron -    22484847 chr1:97263776(+) A-G intron -    22484847 chr1:97263810(+) A-G intron -    22484847 chr1:97263815(+) A-G intron -    22484847 chr1:97263842(+) A-G intron -    22484847 chr1:97263855(+) A-G intron -    22484847 chr1:97263876(+) T-C intron -    22484847 chr1:97263887(+) A-G intron -    22484847 chr1:97263944(+) A-G intron -    22484847 chr1:97264895(+) A-G intron -    22484847 chr1:97264902(+) A-G intron -    22484847 chr1:97264916(+) A-G intron -    22484847 chr1:97264926(+) A-G intron -    22484847 chr1:97264981(+) A-G intron -    22484847 chr1:97264991(+) A-G intron -    22484847 chr1:97265059(+) A-G intron -    22484847 chr1:97266124(+) A-G intron -    22484847 chr1:97266130(+) A-G intron -    22484847 chr1:97266143(+) A-G intron -    22484847 chr1:97266169(+) A-G intron -    22484847 chr1:97267230(+) A-G intron -    22484847 chr1:97267231(+) A-G intron -    22484847

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PTBP2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: PTBP2

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.