Basic Information:

  VIRBase ID:  

HHID00098934

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          FRS2:  NM_001042555     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	FRS2
miRBase Accession/Entrez ID	MIMAT0004489	10818
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FRS1A//FRS2A//FRS2alpha//SNT//SNT-1//SNT1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FRS2	chr12:69883370(+) A-I      intronic chr12:69883400(+) A-I      intronic chr12:69883385(+) A-I      intronic chr12:69883371(+) A-I      intronic chr12:69933054(+) A-I      intronic chr12:69933021(+) A-I      intronic chr12:69933000(+) A-I      intronic chr12:69932994(+) A-I      intronic chr12:69932948(+) A-I      intronic chr12:69932880(+) A-I      intronic chr12:69919773(+) A-I      intronic chr12:69919716(+) A-I      intronic chr12:69919715(+) A-I      intronic chr12:69908591(+) A-I      intronic chr12:69898721(+) A-I      intronic chr12:69898678(+) A-I      intronic chr12:69898662(+) A-I      intronic chr12:69898094(+) A-I      intronic chr12:69897798(+) A-I      intronic chr12:69897764(+) A-I      intronic chr12:69895926(+) A-I      intronic chr12:69889711(+) A-I      intronic chr12:69889637(+) A-I      intronic chr12:69889461(+) A-I      intronic chr12:69889458(+) A-I      intronic chr12:69888794(+) A-I      intronic chr12:69888726(+) A-I      intronic chr12:69888720(+) A-I      intronic chr12:69888719(+) A-I      intronic chr12:69888683(+) A-I      intronic chr12:69888672(+) A-I      intronic chr12:69933615(+) A-I      intronic chr12:69888640(+) A-I      intronic chr12:69888634(+) A-I      intronic chr12:69885475(+) A-I      intronic chr12:69885059(+) A-I      intronic chr12:69885057(+) A-I      intronic chr12:69885048(+) A-I      intronic chr12:69885005(+) A-I      intronic chr12:69884988(+) A-I      intronic chr12:69879362(+) A-I      intronic chr12:69879067(+) A-I      intronic chr12:69878855(+) A-I      intronic chr12:69878752(+) A-I      intronic chr12:69933585(+) A-I      intronic chr12:69866000(+) A-I      intronic chr12:69933660(+) A-I      intronic chr12:69933873(+) A-I      intronic chr12:69933876(+) A-I      intronic chr12:69933886(+) A-I      intronic chr12:69938231(+) A-I      intronic chr12:69938274(+) A-I      intronic chr12:69938393(+) A-I      intronic chr12:69939461(+) A-I      intronic chr12:69940133(+) A-I      intronic chr12:69940318(+) A-I      intronic chr12:69941057(+) A-I      intronic chr12:69945831(+) A-I      intronic chr12:69945861(+) A-I      intronic chr12:69946031(+) A-I      intronic chr12:69946032(+) A-I      intronic chr12:69946037(+) A-I      intronic chr12:69946557(+) A-I      intronic chr12:69947058(+) A-I      intronic chr12:69933572(+) A-I      intronic chr12:69933588(+) A-I      intronic chr12:69933548(+) A-I      intronic chr12:69933580(+) A-I      intronic chr12:69946883(+) A-I      intronic chr12:69889592(+) A-I      intronic chr12:69908349(+) A-I      intronic chr12:69941161(+) A-I      intronic chr12:69885398(+) A-I      intronic chr12:69940063(+) A-I      intronic chr12:69940356(+) A-I      intronic chr12:69940164(+) A-I      intronic chr12:69941816(+) A-I      intronic chr12:69948678(+) A-I      intronic chr12:69924861(+) A-I      intronic chr12:69945844(+) A-I      intronic chr12:69929985(+) A-I      intronic chr12:69932924(+) A-I      intronic chr12:69932878(+) A-I      intronic chr12:69938350(+) A-I      intronic chr12:69939442(+) A-I      intronic chr12:69923706(+) A-I      intronic chr12:69883194(+) A-I      intronic chr12:69932886(+) A-I      intronic chr12:69940312(+) A-I      intronic chr12:69898702(+) A-I      intronic chr12:69941090(+) A-I      intronic chr12:69933922(+) A-I      intronic chr12:69940339(+) A-I      intronic chr12:69890119(+) A-I      intronic chr12:69933912(+) A-I      intronic chr12:69920552(+) A-I      intronic chr12:69941094(+) A-I      intronic chr12:69883297(+) A-I      intronic chr12:69939417(+) A-I      intronic chr12:69952859(+) A-I      intronic chr12:69941720(+) A-I      intronic chr12:69947103(+) A-I      intronic chr12:69889644(+) A-I      intronic chr12:69939390(+) A-I      intronic chr12:69933925(+) A-I      intronic chr12:69935440(+) A-I      intronic chr12:69885096(+) A-I      intronic chr12:69949060(+) A-I      intronic chr12:69883356(+) A-I      intronic chr12:69888607(+) A-I      intronic chr12:69939321(+) A-I      intronic chr12:69878847(+) A-I      intronic chr12:69946981(+) A-I      intronic chr12:69941095(+) A-I      intronic chr12:69939431(+) A-I      intronic chr12:69941669(+) A-I      intronic chr12:69940212(+) A-I      intronic chr12:69946450(+) A-I      intronic chr12:69885381(+) A-I      intronic chr12:69867904(+) A-I      intronic chr12:69901715(+) A-I      intronic chr12:69946629(+) A-I      intronic chr12:69898025(+) A-I      intronic chr12:69940102(+) A-I      intronic chr12:69940243(+) A-I      intronic chr12:69949916(+) A-I      intronic chr12:69933057(+) A-I      intronic chr12:69940112(+) A-I      intronic chr12:69883249(+) A-I      intronic chr12:69939380(+) A-I      intronic chr12:69889486(+) A-I      intronic chr12:69878844(+) A-I      intronic chr12:69933527(+) A-I      intronic chr12:69898841(+) A-I      intronic chr12:69898042(+) A-I      intronic chr12:69920525(+) A-I      intronic chr12:69941760(+) A-I      intronic chr12:69921174(+) A-I      intronic chr12:69890124(+) A-I      intronic chr12:69941175(+) A-I      intronic chr12:69921200(+) A-I      intronic chr12:69962203(+) A-I      intronic chr12:69879528(+) A-I      intronic chr12:69941050(+) A-I      intronic chr12:69932874(+) A-I      intronic chr12:69939326(+) A-I      intronic chr12:69946991(+) A-I      intronic chr12:69940401(+) A-I      intronic chr12:69945852(+) A-I      intronic chr12:69941217(+) A-I      intronic chr12:69938380(+) A-I      intronic chr12:69871116(+) A-I      intronic chr12:69933039(+) A-I      intronic chr12:69939350(+) A-I      intronic chr12:69940163(+) A-I      intronic chr12:69888798(+) A-I      intronic chr12:69940338(+) A-I      intronic chr12:69935364(+) A-I      intronic chr12:69885345(+) A-I      intronic chr12:69938322(+) A-I      intronic chr12:69946913(+) A-I      intronic chr12:69901725(+) A-I      intronic chr12:69950376(+) A-I      intronic chr12:69941148(+) A-I      intronic chr12:69940061(+) A-I      intronic chr12:69941719(+) A-I      intronic chr12:69950316(+) A-I      intronic chr12:69935368(+) A-I      intronic chr12:69932984(+) A-I      intronic chr12:69933524(+) A-I      intronic chr12:69883254(+) A-I      intronic chr12:69930005(+) A-I      intronic chr12:69940353(+) A-I      intronic chr12:69946511(+) A-I      intronic chr12:69888671(+) A-I      intronic chr12:69945096(+) A-I      intronic chr12:69940167(+) A-I      intronic chr12:69883192(+) A-I      intronic chr12:69885512(+) A-I      intronic chr12:69946470(+) A-I      intronic chr12:69938230(+) A-I      intronic chr12:69940131(+) A-I      intronic chr12:69933512(+) A-I      intronic chr12:69947125(+) A-I      intronic chr12:69933939(+) A-I      intronic chr12:69885330(+) A-I      intronic chr12:69946916(+) A-I      intronic chr12:69883339(+) A-I      intronic chr12:69889466(+) A-I      intronic chr12:69939406(+) A-I      intronic chr12:69939360(+) A-I      intronic chr12:69935407(+) A-I      intronic chr12:69946915(+) A-I      intronic chr12:69879169(+) A-I      intronic chr12:69933614(+) A-I      intronic chr12:69867895(+) A-I      intronic chr12:69941110(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FRS2	chr12:69941161(+) A-I intron -    21960545 chr12:69932984(+) A-G intron -    22484847 chr12:69933912(+) A-G intron -    22484847 chr12:69941050(+) A-G intron -    22484847 chr12:69867812(+) G-A intron -    22484847 chr12:69878844(+) A-G intron -    22484847 chr12:69885316(+) A-C intron -    22484847 chr12:69885398(+) A-G intron -    22484847 chr12:69888607(+) A-G intron -    22484847 chr12:69888798(+) A-G intron -    22484847 chr12:69889466(+) A-G intron -    22484847 chr12:69889486(+) A-G intron -    22484847 chr12:69898025(+) A-G intron -    22484847 chr12:69898042(+) A-G intron -    22484847 chr12:69932874(+) A-G intron -    22484847 chr12:69932878(+) A-G intron -    22484847 chr12:69932886(+) A-G intron -    22484847 chr12:69932924(+) A-G intron -    22484847 chr12:69933039(+) A-G intron -    22484847 chr12:69933057(+) A-G intron -    22484847 chr12:69933512(+) A-G intron -    22484847 chr12:69933614(+) A-G intron -    22484847 chr12:69938322(+) A-G intron -    22484847 chr12:69938380(+) A-G intron -    22484847 chr12:69940102(+) A-G intron -    22484847 chr12:69940131(+) A-G intron -    22484847 chr12:69940163(+) A-G intron -    22484847 chr12:69940164(+) A-G intron -    22484847 chr12:69940167(+) A-G intron -    22484847 chr12:69940338(+) A-G intron -    22484847 chr12:69940339(+) A-G intron -    22484847 chr12:69941094(+) A-G intron -    22484847 chr12:69941095(+) A-G intron -    22484847 chr12:69941719(+) A-G intron -    22484847 chr12:69941720(+) A-G intron -    22484847 chr12:69941760(+) A-G intron -    22484847 chr12:69941816(+) A-G intron -    22484847 chr12:69945096(+) A-G intron -    22484847 chr12:69945844(+) A-G intron -    22484847 chr12:69946913(+) A-G intron -    22484847 chr12:69946915(+) A-G intron -    22484847 chr12:69946916(+) A-G intron -    22484847 chr12:69946991(+) A-G intron -    22484847 chr12:69948652(+) C-T intron -    22484847 chr12:69950295(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FRS2	chr12:69864131-69864132(+) m6A 5'UTR       24981863 chr12:69864211-69864212(+) m6A 5'UTR       24981863 chr12:69967830-69967831(+) m6A CDS       27773535//22608085 chr12:69967900-69967901(+) m6A CDS       24284625//24981863//27773535//22608085 chr12:69967917-69967918(+) m6A CDS       24284625//24981863//27773535//22608085 chr12:69967942-69967943(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:69968008-69968009(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:69968067-69968068(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:69968116-69968117(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:69968237-69968238(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:69968250-69968251(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:69968326-69968327(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:69968333-69968334(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:69968448-69968449(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:69968497-69968498(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:69968561-69968562(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:69968594-69968595(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:69968631-69968632(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:69968642-69968643(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:69968702-69968703(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:69968707-69968708(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:69968814-69968815(+) m6A 3'UTR       24209618//24981863//22608085 chr12:69968833-69968834(+) m6A 3'UTR       24209618//24981863//22608085 chr12:69968913-69968914(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	FRS2	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: FRS2

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.