Basic Information:

  VIRBase ID:  

HHID00098932

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          USP15:  NR_147082     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	USP15
miRBase Accession/Entrez ID	MIMAT0004489	9958
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	UNPH-2//UNPH4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	USP15	chr12:62712847(+) A-I      intronic chr12:62712802(+) A-I      intronic chr12:62679764(+) A-I      intronic chr12:62677509(+) A-I      intronic chr12:62712872(+) A-I      intronic chr12:62714208(+) A-I      intronic chr12:62791435(+) A-I      intronic chr12:62712865(+) A-I      intronic chr12:62714039(+) A-I      intronic chr12:62714238(+) A-I      intronic chr12:62714112(+) A-I      intronic chr12:62714230(+) A-I      intronic chr12:62714213(+) A-I      intronic chr12:62714212(+) A-I      intronic chr12:62712874(+) A-I      intronic chr12:62714209(+) A-I      intronic chr12:62712878(+) A-I      intronic chr12:62712887(+) A-I      intronic chr12:62714188(+) A-I      intronic chr12:62679480(+) A-I      intronic chr12:62679493(+) A-I      intronic chr12:62679530(+) A-I      intronic chr12:62713111(+) A-I      intronic chr12:62713004(+) A-I      intronic chr12:62727335(+) A-I      intronic chr12:62724268(+) A-I      intronic chr12:62724259(+) A-I      intronic chr12:62679531(+) A-I      intronic chr12:62679536(+) A-I      intronic chr12:62679656(+) A-I      intronic chr12:62655824(+) A-I      intronic chr12:62791912(+) A-I      intronic chr12:62791557(+) A-I      intronic chr12:62679657(+) A-I      intronic chr12:62781992(+) A-I      intronic chr12:62675285(+) A-I      intronic chr12:62675329(+) A-I      intronic chr12:62782638(+) A-I      intronic chr12:62788535(+) A-I      intronic chr12:62724330(+) A-I      intronic chr12:62788574(+) A-I      intronic chr12:62788581(+) A-I      intronic chr12:62791486(+) A-I      intronic chr12:62724292(+) A-I      intronic chr12:62791516(+) A-I      intronic chr12:62791846(+) A-I      intronic chr12:62791876(+) A-I      intronic chr12:62791881(+) A-I      intronic chr12:62659501(+) A-I      intronic chr12:62791918(+) A-I      intronic chr12:62692326(+) A-I      intronic chr12:62791936(+) A-I      intronic chr12:62675144(+) A-I      intronic chr12:62692262(+) A-I      intronic chr12:62668014(+) A-I      intronic chr12:62675286(+) A-I      intronic chr12:62724288(+) A-I      intronic chr12:62692379(+) A-I      intronic chr12:62668012(+) A-I      intronic chr12:62724115(+) A-I      intronic chr12:62720657(+) A-I      intronic chr12:62727307(+) A-I      intronic chr12:62727349(+) A-I      intronic chr12:62659564(+) A-I      intronic chr12:62720647(+) A-I      intronic chr12:62656496(+) A-I      intronic chr12:62659502(+) A-I      intronic chr12:62692432(+) A-I      intronic chr12:62663333(+) A-I      intronic chr12:62675218(+) A-I      intronic chr12:62724438(+) A-I      intronic chr12:62727350(+) A-I      intronic chr12:62782069(+) A-I      intronic chr12:62724447(+) A-I      intronic chr12:62724468(+) A-I      intronic chr12:62724640(+) A-I      intronic chr12:62725719(+) A-I      intronic chr12:62727065(+) A-I      intronic chr12:62727134(+) A-I      intronic chr12:62727276(+) A-I      intronic chr12:62720791(+) A-I      intronic chr12:62727320(+) A-I      intronic chr12:62727262(+) A-I      intronic chr12:62741719(+) A-I      intronic chr12:62724429(+) A-I      intronic chr12:62724168(+) A-I      intronic chr12:62720674(+) A-I      intronic chr12:62693031(+) A-I      intronic chr12:62727099(+) A-I      intronic chr12:62657793(+) A-I      intronic chr12:62788482(+) A-I      intronic chr12:62782054(+) A-I      intronic chr12:62727173(+) A-I      intronic chr12:62787401(+) A-I      intronic chr12:62724516(+) A-I      intronic chr12:62782762(+) A-I      intronic chr12:62788457(+) A-I      intronic chr12:62675192(+) A-I      intronic chr12:62782118(+) A-I      intronic chr12:62787450(+) A-I      intronic chr12:62675963(+) A-I      intronic chr12:62771390(+) A-I      intronic chr12:62788531(+) A-I      intronic chr12:62725688(+) A-I      intronic chr12:62727347(+) A-I      intronic chr12:62781934(+) A-I      intronic chr12:62791953(+) A-I      intronic chr12:62724520(+) A-I      intronic chr12:62725799(+) A-I      intronic chr12:62787456(+) A-I      intronic chr12:62725682(+) A-I      intronic chr12:62724141(+) A-I      intronic chr12:62656489(+) A-I      intronic chr12:62781964(+) A-I      intronic chr12:62723157(+) A-I      intronic chr12:62725824(+) A-I      intronic chr12:62787552(+) A-I      intronic chr12:62782751(+) A-I      intronic chr12:62725796(+) A-I      intronic chr12:62668056(+) A-I      intronic chr12:62782174(+) A-I      intronic chr12:62782774(+) A-I      intronic chr12:62791517(+) A-I      intronic chr12:62655998(+) A-I      intronic chr12:62727325(+) A-I      intronic chr12:62782654(+) A-I      intronic chr12:62791401(+) A-I      intronic chr12:62791822(+) A-I      intronic chr12:62791384(+) A-I      intronic chr12:62792040(+) A-I      intronic chr12:62725713(+) A-I      intronic chr12:62727193(+) A-I      intronic chr12:62791479(+) A-I      intronic chr12:62791558(+) A-I      intronic chr12:62791552(+) A-I      intronic chr12:62788437(+) A-I      intronic chr12:62792037(+) A-I      intronic chr12:62782758(+) A-I      intronic chr12:62782815(+) A-I      intronic chr12:62727177(+) A-I      intronic chr12:62791546(+) A-I      intronic chr12:62787542(+) A-I      intronic chr12:62771865(+) A-I      intronic chr12:62781982(+) A-I      intronic chr12:62724171(+) A-I      intronic chr12:62657790(+) A-I      intronic chr12:62727187(+) A-I      intronic chr12:62724604(+) A-I      intronic chr12:62791901(+) A-I      intronic chr12:62787624(+) A-I      intronic chr12:62694979(+) A-I      intronic chr12:62788570(+) A-I      intronic chr12:62725834(+) A-I      intronic chr12:62724473(+) A-I      intronic chr12:62714001(+) A-I      intronic chr12:62781993(+) A-I      intronic chr12:62782187(+) A-I      intronic chr12:62679935(+) A-I      intronic chr12:62791910(+) A-I      intronic chr12:62791436(+) A-I      intronic chr12:62713071(+) A-I      intronic chr12:62725795(+) A-I      intronic chr12:62791543(+) A-I      intronic chr12:62713908(+) A-I      intronic chr12:62791594(+) A-I      intronic chr12:62782727(+) A-I      intronic chr12:62668365(+) A-I      intronic chr12:62677652(+) A-I      intronic chr12:62791947(+) A-I      intronic chr12:62675154(+) A-I      intronic chr12:62787469(+) A-I      intronic chr12:62727078(+) A-I      intronic chr12:62782854(+) A-I      intronic chr12:62791871(+) A-I      intronic chr12:62789681(+) A-I      intronic chr12:62725712(+) A-I      intronic chr12:62680795(+) A-I      intronic chr12:62724114(+) A-I      intronic chr12:62727308(+) A-I      intronic chr12:62724632(+) A-I      intronic chr12:62791872(+) A-I      intronic chr12:62676048(+) A-I      intronic chr12:62675923(+) A-I      intronic chr12:62714113(+) A-I      intronic chr12:62679940(+) A-I      intronic chr12:62712781(+) A-I      intronic chr12:62727133(+) A-I      intronic chr12:62782825(+) A-I      intronic chr12:62656545(+) A-I      intronic chr12:62680162(+) A-I      intronic chr12:62787623(+) A-I      intronic chr12:62787487(+) A-I      intronic chr12:62712820(+) A-I      intronic chr12:62791833(+) A-I      intronic chr12:62787636(+) A-I      intronic chr12:62782013(+) A-I      intronic chr12:62727103(+) A-I      intronic chr12:62712961(+) A-I      intronic chr12:62675141(+) A-I      intronic chr12:62727141(+) A-I      intronic chr12:62782699(+) A-I      intronic chr12:62713067(+) A-I      intronic chr12:62712810(+) A-I      intronic chr12:62727122(+) A-I      intronic chr12:62679881(+) A-I      intronic chr12:62788620(+) A-I      intronic chr12:62782655(+) A-I      intronic chr12:62788374(+) A-I      intronic chr12:62694923(+) A-I      intronic chr12:62712803(+) A-I      intronic chr12:62675198(+) A-I      intronic chr12:62713909(+) A-I      intronic chr12:62791481(+) A-I      intronic chr12:62712960(+) A-I      intronic chr12:62782074(+) A-I      intronic chr12:62680374(+) A-I      intronic chr12:62724560(+) A-I      intronic chr12:62668322(+) A-I      intronic chr12:62709463(+) A-I      intronic chr12:62791812(+) A-I      intronic chr12:62727165(+) A-I      intronic chr12:62782808(+) A-I      intronic chr12:62727260(+) A-I      intronic chr12:62788530(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	USP15	chr12:62712961(+) A-I intron -    22327324 chr12:62727099(+) A-I intron -    22327324 chr12:62782074(+) A-I intron -    21960545   //22327324 chr12:62782762(+) A-I intron -    22327324 chr12:62724640(+) A-I intron -    21960545 chr12:62679881(+) A-G intron -    22484847 chr12:62679935(+) A-G intron -    22484847 chr12:62679940(+) A-G intron -    22484847 chr12:62680162(+) A-G intron -    22484847 chr12:62680374(+) A-G intron -    22484847 chr12:62680795(+) A-G intron -    22484847 chr12:62712781(+) A-G intron -    22484847 chr12:62712803(+) A-G intron -    22484847 chr12:62712810(+) A-G intron -    22484847 chr12:62712960(+) A-G intron -    22484847 chr12:62712961(+) A-G intron -    22484847 chr12:62713067(+) A-G intron -    22484847 chr12:62713071(+) A-G intron -    22484847 chr12:62713909(+) A-G intron -    22484847 chr12:62724114(+) A-G intron -    22484847 chr12:62724552(+) C-A intron -    22484847 chr12:62727099(+) A-G intron -    22484847 chr12:62727103(+) A-G intron -    22484847 chr12:62782074(+) A-G intron -    22484847 chr12:62782118(+) A-G intron -    22484847 chr12:62782727(+) A-G intron -    22484847 chr12:62782758(+) A-G intron -    22484847 chr12:62782815(+) A-G intron -    22484847 chr12:62782890(+) G-C intron -    22484847 chr12:62782891(+) T-A intron -    22484847 chr12:62791552(+) A-G intron -    22484847 chr12:62656489(+) A-G intron -    22484847 chr12:62657790(+) A-G intron -    22484847 chr12:62657793(+) A-G intron -    22484847 chr12:62675141(+) A-G intron -    22484847 chr12:62675154(+) A-G intron -    22484847 chr12:62675192(+) A-G intron -    22484847 chr12:62675198(+) A-G intron -    22484847 chr12:62677652(+) A-G intron -    22484847 chr12:62724604(+) A-G intron -    22484847 chr12:62724632(+) A-G intron -    22484847 chr12:62725688(+) A-G intron -    22484847 chr12:62725712(+) A-G intron -    22484847 chr12:62727133(+) A-G intron -    22484847 chr12:62727141(+) A-G intron -    22484847 chr12:62727165(+) A-G intron -    22484847 chr12:62727173(+) A-G intron -    22484847 chr12:62727177(+) A-G intron -    22484847 chr12:62727193(+) A-G intron -    22484847 chr12:62727308(+) A-G intron -    22484847 chr12:62727325(+) A-G intron -    22484847 chr12:62727347(+) A-G intron -    22484847 chr12:62771865(+) A-G intron -    22484847 chr12:62787401(+) A-G intron -    22484847 chr12:62787469(+) A-G intron -    22484847 chr12:62787487(+) A-G intron -    22484847 chr12:62787515(+) A-C intron -    22484847 chr12:62787608(+) C-T intron -    22484847 chr12:62788437(+) A-G intron -    22484847 chr12:62788530(+) A-G intron -    22484847 chr12:62791384(+) A-G intron -    22484847 chr12:62791436(+) A-G intron -    22484847 chr12:62791479(+) A-G intron -    22484847 chr12:62791481(+) A-G intron -    22484847 chr12:62791812(+) A-G intron -    22484847 chr12:62791833(+) A-G intron -    22484847 chr12:62791871(+) A-G intron -    22484847 chr12:62791872(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	USP15	chr12:62654223-62654224(+) m6A CDS//exon       25456834//24981863//22575960 chr12:62654258-62654259(+) m6A CDS//exon       25456834//24981863//22575960 chr12:62654277-62654278(+) m6A CDS//exon       25456834//24981863//22575960 chr12:62672472-62672473(+) m6A 5'UTR//intron       24981863//22575960 chr12:62698530-62698531(+) m6A exon//intron       27773535 chr12:62698537-62698538(+) m6A exon//intron       27773535 chr12:62698546-62698547(+) m6A exon//intron       27773535 chr12:62698561-62698562(+) m6A exon//intron       27773535 chr12:62698648-62698649(+) m6A exon//intron       27773535 chr12:62775386-62775387(+) m6A CDS//exon       27773535 chr12:62777669-62777670(+) m6A CDS//exon       27773535 chr12:62777679-62777680(+) m6A CDS//exon       27773535 chr12:62777736-62777737(+) m6A CDS//exon       24981863//27773535 chr12:62784705-62784706(+) m6A CDS       27773535 chr12:62784947-62784948(+) m6A CDS       27773535 chr12:62784985-62784986(+) m6A CDS       27773535 chr12:62785005-62785006(+) m6A CDS       27773535 chr12:62795044-62795045(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr12:62798004-62798005(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798009-62798010(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798023-62798024(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798050-62798051(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798135-62798136(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:62798181-62798182(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:62798186-62798187(+) Y 3'UTR//exon//intron       26075521 chr12:62798236-62798237(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:62798318-62798319(+) m6A 3'UTR//exon//intron       27773535//22608085 chr12:62798329-62798330(+) m6A 3'UTR//exon//intron       27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	USP15	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: USP15

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.