Basic Information:

  VIRBase ID:  

HHID00098926

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          PRKAA2:  NM_006252     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	PRKAA2
miRBase Accession/Entrez ID	MIMAT0004489	5563
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AMPK//AMPK2//AMPKa2//PRKAA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRKAA2	chr1:57155232(+) A-I      intronic chr1:57152684(+) A-I      intronic chr1:57155333(+) A-I      intronic chr1:57155298(+) A-I      intronic chr1:57178469(+) A-I      3'UTR chr1:57152670(+) A-I      intronic chr1:57118035(+) A-I      intronic chr1:57115387(+) A-I      intronic chr1:57155342(+) A-I      intronic chr1:57155347(+) A-I      intronic chr1:57155363(+) A-I      intronic chr1:57152651(+) A-I      intronic chr1:57115373(+) A-I      intronic chr1:57113635(+) A-I      intronic chr1:57155317(+) A-I      intronic chr1:57155304(+) A-I      intronic chr1:57155227(+) A-I      intronic chr1:57152637(+) A-I      intronic chr1:57129649(+) A-I      intronic chr1:57129633(+) A-I      intronic chr1:57128195(+) A-I      intronic chr1:57125395(+) A-I      intronic chr1:57115703(+) A-I      intronic chr1:57115490(+) A-I      intronic chr1:57123184(+) A-I      intronic chr1:57113447(+) A-I      intronic chr1:57155313(+) A-I      intronic chr1:57113652(+) A-I      intronic chr1:57129668(+) A-I      intronic chr1:57128888(+) A-I      intronic chr1:57156667(+) A-I      intronic chr1:57125564(+) A-I      intronic chr1:57156655(+) A-I      intronic chr1:57137930(+) A-I      intronic chr1:57155381(+) A-I      intronic chr1:57137891(+) A-I      intronic chr1:57152831(+) A-I      intronic chr1:57178269(+) A-I      3'UTR chr1:57115573(+) A-I      intronic chr1:57125458(+) A-I      intronic chr1:57178267(+) A-I      3'UTR chr1:57156104(+) A-I      intronic chr1:57155856(+) A-I      intronic chr1:57115374(+) A-I      intronic chr1:57124607(+) A-I      intronic chr1:57156021(+) A-I      intronic chr1:57155380(+) A-I      intronic chr1:57115424(+) A-I      intronic chr1:57124570(+) A-I      intronic chr1:57113615(+) A-I      intronic chr1:57178405(+) A-I      3'UTR chr1:57124750(+) A-I      intronic chr1:57125500(+) A-I      intronic chr1:57115404(+) A-I      intronic chr1:57156012(+) A-I      intronic chr1:57130921(+) A-I      intronic chr1:57130912(+) A-I      intronic chr1:57178253(+) A-I      3'UTR chr1:57134868(+) A-I      intronic chr1:57124659(+) A-I      intronic chr1:57156064(+) A-I      intronic chr1:57124558(+) A-I      intronic chr1:57156116(+) A-I      intronic chr1:57178363(+) A-I      3'UTR chr1:57156049(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRKAA2	chr1:57169661-57169662(+) m6A CDS       24284625//22608085 chr1:57169693-57169694(+) m6A CDS       24284625//24981863//22608085 chr1:57169780-57169781(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:57169807-57169808(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:57169858-57169859(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:57169946-57169947(+) m6A CDS       24284625//24209618//22608085 chr1:57169981-57169982(+) m6A CDS       24284625//22608085 chr1:57170087-57170088(+) m6A CDS       24284625//24981863//22608085 chr1:57171873-57171874(+) m6A CDS       24284625//24981863//22608085 chr1:57173217-57173218(+) m6A CDS       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	PRKAA2	Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: PRKAA2

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.