Basic Information:

  VIRBase ID:  

HHID00098923

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-16-1-3p:  MIMAT0004489          CSNK1A1:  NM_001892     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-16-1-3p	CSNK1A1
miRBase Accession/Entrez ID	MIMAT0004489	1452
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CK1//CK1a//CKIa//HEL-S-77p//HLCDGP1//PRO2975

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-16-1-3p	rs377111580 chr13:50048986    C/T rs769728617 chr13:50048992    CA/C rs1460126106 chr13:50049003    C/A rs1460126106 chr13:50049003    C/T rs1468155921 chr13:50049001    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CSNK1A1	chr5:148929719(-) A-I      NonSyn:Gln->Arg chr5:148929675(-) A-I      NonSyn:Lys->Glu chr5:148929674(-) A-I      NonSyn:Lys->Arg chr5:148929664(-) A-I      Syn:Gln->Gln chr5:148913933(-) A-I      intronic chr5:148913926(-) A-I      intronic chr5:148913910(-) A-I      intronic chr5:148912053(-) A-I      intronic chr5:148912011(-) A-I      intronic chr5:148911714(-) A-I      intronic chr5:148911708(-) A-I      intronic chr5:148911661(-) A-I      intronic chr5:148911659(-) A-I      intronic chr5:148911573(-) A-I      intronic chr5:148911552(-) A-I      intronic chr5:148911528(-) A-I      intronic chr5:148911519(-) A-I      intronic chr5:148911515(-) A-I      intronic chr5:148911507(-) A-I      intronic chr5:148910853(-) A-I      intronic chr5:148901924(-) A-I      intronic chr5:148901923(-) A-I      intronic chr5:148890832(-) A-I      intronic chr5:148890709(-) A-I      intronic chr5:148890672(-) A-I      intronic chr5:148890188(-) A-I      intronic chr5:148890180(-) A-I      intronic chr5:148925541(-) A-I      intronic chr5:148922530(-) A-I      intronic chr5:148920947(-) A-I      intronic chr5:148889979(-) A-I      intronic chr5:148879157(-) A-I      intronic chr5:148920864(-) A-I      intronic chr5:148879153(-) A-I      intronic chr5:148879142(-) A-I      intronic chr5:148879081(-) A-I      intronic chr5:148879068(-) A-I      intronic chr5:148879055(-) A-I      intronic chr5:148927707(-) A-I      intronic chr5:148927702(-) A-I      intronic chr5:148927680(-) A-I      intronic chr5:148927665(-) A-I      intronic chr5:148927658(-) A-I      intronic chr5:148925738(-) A-I      intronic chr5:148925941(-) A-I      intronic chr5:148926030(-) A-I      intronic chr5:148926032(-) A-I      intronic chr5:148927627(-) A-I      intronic chr5:148928030(-) A-I      intronic chr5:148928099(-) A-I      intronic chr5:148928180(-) A-I      intronic chr5:148928207(-) A-I      intronic chr5:148925737(-) A-I      intronic chr5:148925732(-) A-I      intronic chr5:148925707(-) A-I      intronic chr5:148925697(-) A-I      intronic chr5:148925692(-) A-I      intronic chr5:148928365(-) A-I      intronic chr5:148928312(-) A-I      intronic chr5:148928300(-) A-I      intronic chr5:148928288(-) A-I      intronic chr5:148928277(-) A-I      intronic chr5:148927684(-) A-I      intronic chr5:148927676(-) A-I      intronic chr5:148925573(-) A-I      intronic chr5:148925509(-) A-I      intronic chr5:148925504(-) A-I      intronic chr5:148925499(-) A-I      intronic chr5:148925489(-) A-I      intronic chr5:148927598(-) A-I      intronic chr5:148927582(-) A-I      intronic chr5:148927566(-) A-I      intronic chr5:148927572(-) A-I      intronic chr5:148927571(-) A-I      intronic chr5:148890695(-) A-I      intronic chr5:148927562(-) A-I      intronic chr5:148927548(-) A-I      intronic chr5:148927545(-) A-I      intronic chr5:148927539(-) A-I      intronic chr5:148927531(-) A-I      intronic chr5:148926158(-) A-I      intronic chr5:148926134(-) A-I      intronic chr5:148926110(-) A-I      intronic chr5:148926109(-) A-I      intronic chr5:148890684(-) A-I      intronic chr5:148890644(-) A-I      intronic chr5:148880219(-) A-I      intronic chr5:148920580(-) A-I      intronic chr5:148926084(-) A-I      intronic chr5:148925576(-) A-I      intronic chr5:148920531(-) A-I      intronic chr5:148920524(-) A-I      intronic chr5:148920456(-) A-I      intronic chr5:148925549(-) A-I      intronic chr5:148920449(-) A-I      intronic chr5:148919031(-) A-I      intronic chr5:148918996(-) A-I      intronic chr5:148918929(-) A-I      intronic chr5:148918858(-) A-I      intronic chr5:148918373(-) A-I      intronic chr5:148918855(-) A-I      intronic chr5:148918441(-) A-I      intronic chr5:148918403(-) A-I      intronic chr5:148910923(-) A-I      intronic chr5:148918366(-) A-I      intronic chr5:148918241(-) A-I      intronic chr5:148916817(-) A-I      intronic chr5:148916804(-) A-I      intronic chr5:148916736(-) A-I      intronic chr5:148916721(-) A-I      intronic chr5:148916704(-) A-I      intronic chr5:148915641(-) A-I      intronic chr5:148915614(-) A-I      intronic chr5:148915609(-) A-I      intronic chr5:148915607(-) A-I      intronic chr5:148915555(-) A-I      intronic chr5:148915481(-) A-I      intronic chr5:148915412(-) A-I      intronic chr5:148915405(-) A-I      intronic chr5:148915391(-) A-I      intronic chr5:148925276(-) A-I      intronic chr5:148915238(-) A-I      intronic chr5:148872743(-) A-I      3'UTR chr5:148872807(-) A-I      3'UTR chr5:148920751(-) A-I      intronic chr5:148926033(-) A-I      intronic chr5:148921007(-) A-I      intronic chr5:148915602(-) A-I      intronic chr5:148890261(-) A-I      intronic chr5:148890671(-) A-I      intronic chr5:148925954(-) A-I      intronic chr5:148923393(-) A-I      intronic chr5:148920461(-) A-I      intronic chr5:148915692(-) A-I      intronic chr5:148923369(-) A-I      intronic chr5:148928417(-) A-I      intronic chr5:148925519(-) A-I      intronic chr5:148911245(-) A-I      intronic chr5:148926072(-) A-I      intronic chr5:148911721(-) A-I      intronic chr5:148890206(-) A-I      intronic chr5:148925729(-) A-I      intronic chr5:148927706(-) A-I      intronic chr5:148915619(-) A-I      intronic chr5:148928355(-) A-I      intronic chr5:148915693(-) A-I      intronic chr5:148890318(-) A-I      intronic chr5:148915436(-) A-I      intronic chr5:148925520(-) A-I      intronic chr5:148926127(-) A-I      intronic chr5:148911018(-) A-I      intronic chr5:148879080(-) A-I      intronic chr5:148916827(-) A-I      intronic chr5:148920521(-) A-I      intronic chr5:148879133(-) A-I      intronic chr5:148921373(-) A-I      intronic chr5:148880242(-) A-I      intronic chr5:148913995(-) A-I      intronic chr5:148928349(-) A-I      intronic chr5:148917857(-) A-I      intronic chr5:148918294(-) A-I      intronic chr5:148911688(-) A-I      intronic chr5:148927701(-) A-I      intronic chr5:148920413(-) A-I      intronic chr5:148889947(-) A-I      intronic chr5:148927885(-) A-I      intronic chr5:148890849(-) A-I      intronic chr5:148915316(-) A-I      intronic chr5:148920655(-) A-I      intronic chr5:148872798(-) A-I      3'UTR chr5:148872853(-) A-I      3'UTR chr5:148872802(-) A-I      3'UTR chr5:148872758(-) A-I      3'UTR chr5:148872833(-) A-I      3'UTR chr5:148872828(-) A-I      3'UTR chr5:148872852(-) A-I      3'UTR chr5:148872771(-) A-I      3'UTR chr5:148872745(-) A-I      3'UTR chr5:148872739(-) A-I      3'UTR chr5:148872838(-) A-I      3'UTR chr5:148872837(-) A-I      3'UTR chr5:148872811(-) A-I      3'UTR chr5:148872710(-) A-I      3'UTR chr5:148872772(-) A-I      3'UTR chr5:148872014(-) A-I      3'UTR chr5:148872810(-) A-I      3'UTR chr5:148872723(-) A-I      3'UTR chr5:148872730(-) A-I      3'UTR chr5:148872742(-) A-I      3'UTR chr5:148872749(-) A-I      3'UTR chr5:148872701(-) A-I      3'UTR chr5:148879090(-) A-I      intronic chr5:148890641(-) A-I      intronic chr5:148922537(-) A-I      intronic chr5:148928290(-) A-I      intronic chr5:148928329(-) A-I      intronic chr5:148879152(-) A-I      intronic chr5:148915780(-) A-I      intronic chr5:148890203(-) A-I      intronic chr5:148914250(-) A-I      intronic chr5:148889986(-) A-I      intronic chr5:148915290(-) A-I      intronic chr5:148926074(-) A-I      intronic chr5:148879160(-) A-I      intronic chr5:148915446(-) A-I      intronic chr5:148890837(-) A-I      intronic chr5:148923335(-) A-I      intronic chr5:148921418(-) A-I      intronic chr5:148915495(-) A-I      intronic chr5:148913961(-) A-I      intronic chr5:148915789(-) A-I      intronic chr5:148915681(-) A-I      intronic chr5:148927507(-) A-I      intronic chr5:148928416(-) A-I      intronic chr5:148879074(-) A-I      intronic chr5:148912134(-) A-I      intronic chr5:148912005(-) A-I      intronic chr5:148913788(-) A-I      intronic chr5:148880257(-) A-I      intronic chr5:148880234(-) A-I      intronic chr5:148890088(-) A-I      intronic chr5:148879107(-) A-I      intronic chr5:148926150(-) A-I      intronic chr5:148920813(-) A-I      intronic chr5:148925590(-) A-I      intronic chr5:148927964(-) A-I      intronic chr5:148928330(-) A-I      intronic chr5:148920727(-) A-I      intronic chr5:148920472(-) A-I      intronic chr5:148920821(-) A-I      intronic chr5:148911228(-) A-I      intronic chr5:148911514(-) A-I      intronic chr5:148920853(-) A-I      intronic chr5:148914346(-) A-I      intronic chr5:148926087(-) A-I      intronic chr5:148914359(-) A-I      intronic chr5:148889989(-) A-I      intronic chr5:148928167(-) A-I      intronic chr5:148927537(-) A-I      intronic chr5:148890260(-) A-I      intronic chr5:148911544(-) A-I      intronic chr5:148912020(-) A-I      intronic chr5:148914249(-) A-I      intronic chr5:148921366(-) A-I      intronic chr5:148890826(-) A-I      intronic chr5:148890138(-) A-I      intronic chr5:148921322(-) A-I      intronic chr5:148927653(-) A-I      intronic chr5:148914298(-) A-I      intronic chr5:148915369(-) A-I      intronic chr5:148911619(-) A-I      intronic chr5:148879967(-) A-I      intronic chr5:148927685(-) A-I      intronic chr5:148920399(-) A-I      intronic chr5:148911693(-) A-I      intronic chr5:148918337(-) A-I      intronic chr5:148928054(-) A-I      intronic chr5:148925484(-) A-I      intronic chr5:148928368(-) A-I      intronic chr5:148926113(-) A-I      intronic chr5:148911312(-) A-I      intronic chr5:148923463(-) A-I      intronic chr5:148928161(-) A-I      intronic chr5:148915589(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CSNK1A1	chr5:148879074(-) A-I intron -    21960545   //22327324 chr5:148879107(-) A-I intron -    21960545 chr5:148880242(-) A-I intron -    21960545 chr5:148875327(-) C-T exon 3'UTR    21725310 chr5:148877575(-) T-A intron -    22484847 chr5:148877638(-) T-G intron -    22484847 chr5:148879074(-) A-G intron -    22484847 chr5:148879967(-) A-G intron -    22484847 chr5:148880242(-) A-G intron -    22484847 chr5:148880257(-) A-G intron -    22484847 chr5:148882418(-) T-C intron -    22484847 chr5:148882435(-) T-G intron -    22484847 chr5:148882512(-) A-T intron -    22484847 chr5:148888661(-) G-A intron -    22484847 chr5:148890203(-) A-G intron -    22484847 chr5:148890837(-) A-G intron -    22484847 chr5:148911228(-) A-G intron -    22484847 chr5:148911245(-) A-G intron -    22484847 chr5:148911269(-) T-G intron -    22484847 chr5:148911270(-) T-G intron -    22484847 chr5:148911271(-) G-T intron -    22484847 chr5:148911276(-) T-G intron -    22484847 chr5:148911278(-) G-T intron -    22484847 chr5:148911688(-) A-G intron -    22484847 chr5:148911692(-) A-G intron -    22484847 chr5:148911693(-) A-G intron -    22484847 chr5:148911701(-) A-G intron -    22484847 chr5:148911721(-) A-G intron -    22484847 chr5:148912005(-) A-G intron -    22484847 chr5:148912090(-) A-G intron -    22484847 chr5:148912093(-) A-G intron -    22484847 chr5:148912134(-) A-G intron -    22484847 chr5:148913961(-) A-G intron -    22484847 chr5:148913995(-) A-G intron -    22484847 chr5:148914249(-) A-G intron -    22484847 chr5:148914250(-) A-G intron -    22484847 chr5:148915208(-) G-C intron -    22484847 chr5:148915316(-) A-G intron -    22484847 chr5:148915356(-) A-G intron -    22484847 chr5:148915681(-) A-G intron -    22484847 chr5:148915780(-) A-G intron -    22484847 chr5:148916827(-) A-G intron -    22484847 chr5:148918268(-) A-G intron -    22484847 chr5:148918294(-) A-G intron -    22484847 chr5:148918314(-) G-A intron -    22484847 chr5:148918337(-) A-G intron -    22484847 chr5:148918402(-) A-G intron -    22484847 chr5:148920413(-) A-G intron -    22484847 chr5:148920461(-) A-G intron -    22484847 chr5:148920853(-) A-G intron -    22484847 chr5:148921007(-) A-G intron -    22484847 chr5:148921322(-) A-G intron -    22484847 chr5:148921366(-) A-G intron -    22484847 chr5:148921418(-) A-G intron -    22484847 chr5:148923393(-) A-G intron -    22484847 chr5:148923454(-) T-G intron -    22484847 chr5:148924071(-) A-T intron -    22484847 chr5:148924072(-) A-T intron -    22484847 chr5:148925484(-) A-G intron -    22484847 chr5:148925519(-) A-G intron -    22484847 chr5:148925520(-) A-G intron -    22484847 chr5:148925563(-) A-G intron -    22484847 chr5:148925580(-) A-G intron -    22484847 chr5:148925590(-) A-G intron -    22484847 chr5:148925729(-) A-G intron -    22484847 chr5:148925953(-) A-G intron -    22484847 chr5:148925954(-) A-G intron -    22484847 chr5:148926068(-) A-G intron -    22484847 chr5:148926072(-) A-G intron -    22484847 chr5:148926074(-) A-G intron -    22484847 chr5:148926087(-) A-G intron -    22484847 chr5:148926113(-) A-G intron -    22484847 chr5:148926114(-) A-G intron -    22484847 chr5:148926127(-) A-G intron -    22484847 chr5:148926150(-) A-G intron -    22484847 chr5:148927530(-) A-G intron -    22484847 chr5:148927653(-) A-G intron -    22484847 chr5:148927661(-) A-G intron -    22484847 chr5:148927685(-) A-G intron -    22484847 chr5:148927701(-) A-G intron -    22484847 chr5:148927895(-) A-G intron -    22484847 chr5:148928290(-) A-G intron -    22484847 chr5:148928330(-) A-G intron -    22484847 chr5:148928417(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CSNK1A1	chr5:148872559-148872560(-) m6A 3'UTR       27773535 chr5:148872660-148872661(-) m6A 3'UTR       24981863//27773535 chr5:148872729-148872730(-) m6A 3'UTR       24981863 chr5:148872826-148872827(-) m6A 3'UTR       27773535//22608085 chr5:148872849-148872850(-) m6A 3'UTR       24284625//27773535//22608085 chr5:148872976-148872977(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr5:148872983-148872984(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr5:148873037-148873038(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr5:148873050-148873051(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr5:148873096-148873097(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr5:148873148-148873149(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr5:148873168-148873169(-) m6A 3'UTR       24981863//27773535//22608085 chr5:148873893-148873894(-) m6A 3'UTR       27773535 chr5:148874042-148874043(-) m6A 3'UTR       24981863//27773535 chr5:148874082-148874083(-) m6A 3'UTR       24981863//27773535 chr5:148874105-148874106(-) m6A 3'UTR       24981863//27773535 chr5:148875675-148875676(-) m6A 3'UTR//CDS       - chr5:148875758-148875759(-) m6A 3'UTR//5'UTR       24284625//24981863//22608085 chr5:148875786-148875787(-) m6A 3'UTR//5'UTR       24284625//24981863//22575960//22608085 chr5:148875797-148875798(-) m6A 3'UTR//5'UTR       24284625//24981863//22575960//22608085 chr5:148875844-148875845(-) m6A 3'UTR//5'UTR       24284625//24981863//22575960//22608085 chr5:148875928-148875929(-) m6A 3'UTR//5'UTR       24284625//24981863//22575960//22608085 chr5:148876025-148876026(-) m6A 3'UTR//5'UTR       24284625 chr5:148876066-148876067(-) m6A 3'UTR//5'UTR       24284625 chr5:148876188-148876189(-) m6A 3'UTR//5'UTR       24284625//24981863//22575960//22608085 chr5:148876267-148876268(-) m6A 3'UTR//5'UTR       24284625//24981863//22575960//22608085 chr5:148876284-148876285(-) m6A 3'UTR//5'UTR       24284625//24981863//22575960//22608085 chr5:148876308-148876309(-) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:148876400-148876401(-) m6A 3'UTR//intron       24981863//22608085 chr5:148877195-148877196(-) m6A intron       27773535 chr5:148877278-148877279(-) m6A intron       27773535 chr5:148877343-148877344(-) m1A intron       26863196 chr5:148877361-148877362(-) m6A intron       27773535 chr5:148877396-148877397(-) m6A intron       24981863//27773535 chr5:148877423-148877424(-) m6A intron       24981863//27773535//27371828 chr5:148877492-148877493(-) m6A intron       24981863//27773535 chr5:148878509-148878510(-) m6A intron       24284625//27773535//22608085 chr5:148878640-148878641(-) m6A intron       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr5:148878663-148878664(-) m6A intron       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr5:148878708-148878709(-) m6A intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr5:148878748-148878749(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr5:148878755-148878756(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr5:148878790-148878791(-) Am 3'UTR//intron       - chr5:148878798-148878799(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:148880580-148880581(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:148880614-148880615(-) m6A 3'UTR//intron       27773535//22608085 chr5:148880661-148880662(-) m6A 3'UTR//intron       27773535//22608085 chr5:148880717-148880718(-) m6A 5'UTR//CDS//intron       24284625//27773535//22608085 chr5:148880725-148880726(-) m6A 5'UTR//CDS//intron       24284625//27773535//22608085 chr5:148880819-148880820(-) m6A intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr5:148880874-148880875(-) m6A intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr5:148880917-148880918(-) m6A intron       24284625//24981863//27773535//27371828//22575960//22608085 chr5:148880926-148880927(-) m6A intron       24284625//24981863//27773535//27371828//22575960//22608085 chr5:148881152-148881153(-) m6A intron       27773535 chr5:148884523-148884524(-) m6A 3'UTR//intron       25456834//27773535 chr5:148925058-148925059(-) m6A intron       27371828 chr5:148925133-148925134(-) m6A intron       27773535//27371828 chr5:148930438-148930439(-) m6A CDS       27773535 chr5:148930463-148930464(-) Am CDS       - chr5:148930473-148930474(-) m6A CDS       24284625//27773535 chr5:148930662-148930663(-) m6A 5'UTR       24284625//25456834//27371828//27773536//22575960 chr5:148930714-148930715(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960 chr5:148930735-148930736(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960 chr5:148930777-148930778(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22575960//22608085 chr5:148930962-148930963(-) m6A 5'UTR       24284625//24981863//27371828//27773536//22608085 chr5:148930977-148930978(-) m1A 5'UTR       26863196//26863410

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-16-1-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CSNK1A1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-16-1-3p
Interactor2: CSNK1A1

Evidence Support:

Weak-Evidence	Illumina sequencing
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	32223537	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Calu-3 cells	Interactor2 expression	Upregulation
Description	The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.