Detail Information

Basic Information:


  VIRBase ID:  

HHID00098907

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-539-5p:           TSPAN14:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-539-5p TSPAN14
miRBase
Accession/Entrez ID		 MIMAT0003163 81619
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DC-TM4F2//TM4SF14//tspan-14

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-539-5p
rs1261686093 chr14:101047338    A/G
rs1397145918 chr14:101047350    TTCGCTTTATTTA/T
rs747290147 chr14:101047347    G/A
rs750261997 chr14:101047326    TGAG/T
rs920592001 chr14:101047329    G/A
rs1037241141 chr14:101047332    G/T
rs949143380 chr14:101047330    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TSPAN14
chr10:82235171(+) A-I      intronic
chr10:82235170(+) A-I      intronic
chr10:82243488(+) A-I      intronic
chr10:82217086(+) A-I      intronic
chr10:82217084(+) A-I      intronic
chr10:82243838(+) A-I      intronic
chr10:82217074(+) A-I      intronic
chr10:82243850(+) A-I      intronic
chr10:82215570(+) A-I      intronic
chr10:82216663(+) A-I      intronic
chr10:82243858(+) A-I      intronic
chr10:82243951(+) A-I      intronic
chr10:82235138(+) A-I      intronic
chr10:82243445(+) A-I      intronic
chr10:82226252(+) A-I      5'UTR
chr10:82235175(+) A-I      intronic
chr10:82243925(+) A-I      intronic
chr10:82281995(+) A-I      3'UTR
chr10:82243836(+) A-I      intronic
chr10:82243508(+) A-I      intronic
chr10:82235162(+) A-I      intronic
chr10:82282223(+) A-I      3'UTR
chr10:82282249(+) A-I      3'UTR
chr10:82282120(+) A-I      3'UTR
chr10:82282111(+) A-I      3'UTR
chr10:82282095(+) A-I      3'UTR
chr10:82282071(+) A-I      3'UTR
chr10:82282057(+) A-I      3'UTR
chr10:82282034(+) A-I      3'UTR
chr10:82282017(+) A-I      3'UTR
chr10:82242324(+) A-I      intronic
chr10:82244188(+) A-I      intronic
chr10:82242179(+) A-I      intronic
chr10:82243839(+) A-I      intronic
chr10:82242172(+) A-I      intronic
chr10:82243581(+) A-I      intronic
chr10:82243843(+) A-I      intronic
chr10:82242136(+) A-I      intronic
chr10:82238528(+) A-I      intronic
chr10:82243559(+) A-I      intronic
chr10:82243450(+) A-I      intronic
chr10:82217071(+) A-I      intronic
chr10:82235617(+) A-I      intronic
chr10:82243478(+) A-I      intronic
chr10:82243479(+) A-I      intronic
chr10:82241691(+) A-I      intronic
chr10:82243607(+) A-I      intronic
chr10:82243618(+) A-I      intronic
chr10:82241716(+) A-I      intronic
chr10:82243750(+) A-I      intronic
chr10:82235211(+) A-I      intronic
chr10:82243760(+) A-I      intronic
chr10:82243455(+) A-I      intronic
chr10:82243745(+) A-I      intronic
chr10:82243801(+) A-I      intronic
chr10:82243842(+) A-I      intronic
chr10:82243577(+) A-I      intronic
chr10:82243481(+) A-I      intronic
chr10:82243890(+) A-I      intronic
chr10:82244174(+) A-I      intronic
chr10:82235059(+) A-I      intronic
chr10:82240755(+) A-I      intronic
chr10:82244181(+) A-I      intronic
chr10:82235163(+) A-I      intronic
chr10:82243912(+) A-I      intronic
chr10:82243921(+) A-I      intronic
chr10:82244158(+) A-I      intronic
chr10:82244240(+) A-I      intronic
chr10:82243840(+) A-I      intronic
chr10:82271643(+) A-I      intronic
chr10:82240773(+) A-I      intronic
chr10:82243410(+) A-I      intronic
chr10:82243507(+) A-I      intronic
chr10:82243407(+) A-I      intronic
chr10:82243449(+) A-I      intronic
chr10:82241649(+) A-I      intronic
chr10:82243578(+) A-I      intronic
chr10:82243519(+) A-I      intronic
chr10:82282152(+) A-I      3'UTR
chr10:82282216(+) A-I      3'UTR
chr10:82282033(+) A-I      3'UTR
chr10:82282128(+) A-I      3'UTR
chr10:82282091(+) A-I      3'UTR
chr10:82282038(+) A-I      3'UTR
chr10:82282028(+) A-I      3'UTR
chr10:82281669(+) A-I      3'UTR
chr10:82282179(+) A-I      3'UTR
chr10:82282188(+) A-I      3'UTR
chr10:82282209(+) A-I      3'UTR
chr10:82282173(+) A-I      3'UTR
chr10:82282199(+) A-I      3'UTR
chr10:82235970(+) A-I      intronic
chr10:82243654(+) A-I      intronic
chr10:82235195(+) A-I      intronic
chr10:82271654(+) A-I      intronic
chr10:82244210(+) A-I      intronic
chr10:82243572(+) A-I      intronic
chr10:82244257(+) A-I      intronic
chr10:82241521(+) A-I      intronic
chr10:82243854(+) A-I      intronic
chr10:82240750(+) A-I      intronic
chr10:82243942(+) A-I      intronic
chr10:82235049(+) A-I      intronic
chr10:82243415(+) A-I      intronic
chr10:82243766(+) A-I      intronic
chr10:82243527(+) A-I      intronic
chr10:82270551(+) A-I      intronic
chr10:82243851(+) A-I      intronic
chr10:82243908(+) A-I      intronic
chr10:82240767(+) A-I      intronic
chr10:82215549(+) A-I      intronic
chr10:82235967(+) A-I      intronic
chr10:82246762(+) A-I      intronic
chr10:82243744(+) A-I      intronic
chr10:82252385(+) A-I      intronic
chr10:82235476(+) A-I      intronic
chr10:82240793(+) A-I      intronic
chr10:82236008(+) A-I      intronic
chr10:82244180(+) A-I      intronic
chr10:82231749(+) A-I      intronic
chr10:82235942(+) A-I      intronic
chr10:82216564(+) A-I      intronic
chr10:82243440(+) A-I      intronic
chr10:82228542(+) A-I      intronic
chr10:82235365(+) A-I      intronic
chr10:82235557(+) A-I      intronic
chr10:82243841(+) A-I      intronic
chr10:82241627(+) A-I      intronic
chr10:82244235(+) A-I      intronic
chr10:82243825(+) A-I      intronic
chr10:82243815(+) A-I      intronic
chr10:82243848(+) A-I      intronic
chr10:82235995(+) A-I      intronic
chr10:82241675(+) A-I      intronic
chr10:82243501(+) A-I      intronic
chr10:82243903(+) A-I      intronic
chr10:82235946(+) A-I      intronic
chr10:82241639(+) A-I      intronic
chr10:82235140(+) A-I      intronic
chr10:82243516(+) A-I      intronic
chr10:82240741(+) A-I      intronic
chr10:82243916(+) A-I      intronic
chr10:82235164(+) A-I      intronic
chr10:82244185(+) A-I      intronic
chr10:82243489(+) A-I      intronic
chr10:82240715(+) A-I      intronic
chr10:82235126(+) A-I      intronic
chr10:82243546(+) A-I      intronic
chr10:82244217(+) A-I      intronic
chr10:82243545(+) A-I      intronic
chr10:82228526(+) A-I      intronic
chr10:82235065(+) A-I      intronic
chr10:82274988(+) A-I      intronic
chr10:82282102(+) A-I      3'UTR
chr10:82282105(+) A-I      3'UTR
chr10:82282146(+) A-I      3'UTR
chr10:82282081(+) A-I      3'UTR
chr10:82282011(+) A-I      3'UTR
chr10:82275015(+) A-I      intronic
chr10:82282042(+) A-I      3'UTR
chr10:82275009(+) A-I      intronic
chr10:82282163(+) A-I      3'UTR
chr10:82281533(+) A-I      3'UTR
chr10:82281989(+) A-I      3'UTR
chr10:82281559(+) A-I      3'UTR
chr10:82275092(+) A-I      intronic
chr10:82226285(+) A-I      5'UTR
chr10:82274682(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TSPAN14
chr10:82214067-82214068(+) m6A 5'UTR       24209618//24981863
chr10:82219075-82219076(+) m6A 5'UTR//intron       24209618//24981863
chr10:82277697-82277698(+) m6A CDS//exon       24284625//26404942
chr10:82277898-82277899(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82277927-82277928(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82277962-82277963(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278003-82278004(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278044-82278045(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278073-82278074(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278104-82278105(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278153-82278154(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278167-82278168(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278271-82278272(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278345-82278346(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278412-82278413(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960//22608085
chr10:82278651-82278652(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr10:82278852-82278853(+) m6A 3'UTR//exon       -
chr10:82279175-82279176(+) m6A 3'UTR//exon       26404942
chr10:82279466-82279467(+) m6A 3'UTR       -
chr10:82279487-82279488(+) m6A 3'UTR       -
chr10:82280428-82280429(+) m6A 3'UTR       24981863
chr10:82280588-82280589(+) m6A 3'UTR       24981863
chr10:82280967-82280968(+) m6A 3'UTR       24284625
chr10:82281005-82281006(+) m6A 3'UTR       24284625
chr10:82281736-82281737(+) m6A 3'UTR       24981863//26404942//27773535
chr10:82281757-82281758(+) m6A 3'UTR       24209618//24981863//26404942//27773535
chr10:82281892-82281893(+) m6A 3'UTR       24209618//24981863//26404942
chr10:82281981-82281982(+) m6A 3'UTR       25456834//24981863
chr10:82282019-82282020(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282035-82282036(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282067-82282068(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282077-82282078(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282187-82282188(+) m6A 3'UTR       24981863//27773535
chr10:82282196-82282197(+) m6A 3'UTR       24981863//27773535
chr10:82282253-82282254(+) m6A 3'UTR       24981863//27773535
chr10:82282284-82282285(+) m6A 3'UTR       24981863//27773535
chr10:82282310-82282311(+) m6A 3'UTR       24981863//27773535
chr10:82282320-82282321(+) m6A 3'UTR       24981863//27773535
chr10:82282331-82282332(+) m6A 3'UTR       24981863//27773535
chr10:82282370-82282371(+) m6A 3'UTR       24981863//27773535
chr10:82285742-82285743(+) m6A 3'UTR       24981863
chr10:82285750-82285751(+) m6A 3'UTR       24981863
chr10:82285795-82285796(+) m6A 3'UTR       24981863
chr10:82287822-82287823(+) m6A 3'UTR       24981863
chr10:82287863-82287864(+) m6A 3'UTR       24981863
chr10:82288340-82288341(+) m6A 3'UTR       -
chr10:82288443-82288444(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-539-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
TSPAN14
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-539-5p
8-Aminoadenosine 96851 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Berberine iodide 72350 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
2-Azaadenine 5480214 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Isobrucein A 441802 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Antimycin A3 245869 Drug sensitive
Sarcoviolin 24202820 Drug sensitive
Kinetin riboside 20345 Drug resistant
{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug resistant
(1S,3S,5'R,6S,6'S,8R,9Z,14R,15S,16R,17R,18R,19S,20S,21E,25S,27S,29R)-3,14,15,17,19,20-Hexahydroxy-6'-[(2S)-2-hydroxybutyl]-16-[(2S,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',6,14,18,20,29-hexamethylspiro[4,24,28-trioxatricyclo[23.3.1.03,8]nonacosa-9,21-diene-27,2'-oxane]-23-one 139589095 Drug sensitive
Formycin b 135449281 Drug resistant
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Unii-9JU14BJ5QG 109374088 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
2-bromo-3-ketocastanospermine - Drug resistant
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
leucinostatine d - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-539-5p
Atorvastatin 60823 Drug interaction    RC00005841
Doxorubicin 31703 Drug interaction    RC00005840
Verapamil 2520 Drug interaction    RC00005839
Biotin 171548 Drug interaction    RC00005842

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-539-5p
Interactor2: TSPAN14

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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