Detail Information

Basic Information:


  VIRBase ID:  

HHID00098890

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-539-5p:           ACVR2B:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-539-5p ACVR2B
miRBase
Accession/Entrez ID		 MIMAT0003163 93
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ActR-IIB//ACTRIIB//HTX4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-539-5p
rs1261686093 chr14:101047338    A/G
rs1397145918 chr14:101047350    TTCGCTTTATTTA/T
rs747290147 chr14:101047347    G/A
rs750261997 chr14:101047326    TGAG/T
rs920592001 chr14:101047329    G/A
rs1037241141 chr14:101047332    G/T
rs949143380 chr14:101047330    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ACVR2B
chr3:38504502(+) A-I      intronic
chr3:38506734(+) A-I      intronic
chr3:38506743(+) A-I      intronic
chr3:38509580(+) A-I      intronic
chr3:38509606(+) A-I      intronic
chr3:38509632(+) A-I      intronic
chr3:38509633(+) A-I      intronic
chr3:38528823(+) A-I      3'UTR
chr3:38509433(+) A-I      intronic
chr3:38506821(+) A-I      intronic
chr3:38508689(+) A-I      intronic
chr3:38506306(+) A-I      intronic
chr3:38509051(+) A-I      intronic
chr3:38508684(+) A-I      intronic
chr3:38509128(+) A-I      intronic
chr3:38509218(+) A-I      intronic
chr3:38509094(+) A-I      intronic
chr3:38508780(+) A-I      intronic
chr3:38509168(+) A-I      intronic
chr3:38509509(+) A-I      intronic
chr3:38509132(+) A-I      intronic
chr3:38509499(+) A-I      intronic
chr3:38509623(+) A-I      intronic
chr3:38509146(+) A-I      intronic
chr3:38508869(+) A-I      intronic
chr3:38508690(+) A-I      intronic
chr3:38506796(+) A-I      intronic
chr3:38506293(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ACVR2B
chr3:38508246(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACVR2B
chr3:38495418-38495419(+) m6A 5'UTR       24981863
chr3:38495472-38495473(+) m6A 5'UTR       24981863
chr3:38495698-38495699(+) m6A 5'UTR       25456834
chr3:38524044-38524045(+) m6A CDS//exon       24284625
chr3:38524668-38524669(+) m6A CDS//exon       24284625//22608085
chr3:38524755-38524756(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085
chr3:38524794-38524795(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr3:38524830-38524831(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085
chr3:38524848-38524849(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085
chr3:38524909-38524910(+) m6A 3'UTR       25456834//24981863//22608085
chr3:38524917-38524918(+) m6A 3'UTR       25456834//24981863//22608085
chr3:38525049-38525050(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr3:38525056-38525057(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr3:38525097-38525098(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr3:38525198-38525199(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr3:38525219-38525220(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr3:38525233-38525234(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr3:38525248-38525249(+) m6A 3'UTR       24284625//24981863//22575960//22608085
chr3:38525258-38525259(+) m6A 3'UTR       24284625//24981863//22575960//22608085
chr3:38525272-38525273(+) m6A 3'UTR       24284625//24981863//22575960//22608085
chr3:38525370-38525371(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr3:38525424-38525425(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr3:38525445-38525446(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr3:38525489-38525490(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr3:38525504-38525505(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085
chr3:38525577-38525578(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr3:38531188-38531189(+) m6A 3'UTR       -
chr3:38531227-38531228(+) m6A 3'UTR       -
chr3:38534519-38534520(+) Y 3'UTR       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-539-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
ACVR2B
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-539-5p
8-Aminoadenosine 96851 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Berberine iodide 72350 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
2-Azaadenine 5480214 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Isobrucein A 441802 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Antimycin A3 245869 Drug sensitive
Sarcoviolin 24202820 Drug sensitive
Kinetin riboside 20345 Drug resistant
{4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug resistant
(1S,3S,5'R,6S,6'S,8R,9Z,14R,15S,16R,17R,18R,19S,20S,21E,25S,27S,29R)-3,14,15,17,19,20-Hexahydroxy-6'-[(2S)-2-hydroxybutyl]-16-[(2S,4R,5S,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',6,14,18,20,29-hexamethylspiro[4,24,28-trioxatricyclo[23.3.1.03,8]nonacosa-9,21-diene-27,2'-oxane]-23-one 139589095 Drug sensitive
Formycin b 135449281 Drug resistant
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Unii-9JU14BJ5QG 109374088 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
2-bromo-3-ketocastanospermine - Drug resistant
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
leucinostatine d - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-539-5p
Atorvastatin 60823 Drug interaction    RC00005841
Doxorubicin 31703 Drug interaction    RC00005840
Verapamil 2520 Drug interaction    RC00005839
Biotin 171548 Drug interaction    RC00005842

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-539-5p
Interactor2: ACVR2B

Evidence Support:


Weak-Evidence Illumina sequencing
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression Downregulation
Description The miRNA-mRNA pairs with strong correlations were selected for miRNA-mRNA binding site prediction using miRanda.

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