Detail Information

Basic Information:


  VIRBase ID:  

HHID00098620

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa_circ_0002248 SPRYD4
miRBase
Accession/Entrez ID		 hsa_circ_0002248 283377
Organism Homo sapiens Homo sapiens
Category circRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SPRYD4
chr12:56864318(+) A-I      3'UTR
chr12:56864371(+) A-I      3'UTR
chr12:56864209(+) A-I      3'UTR
chr12:56864311(+) A-I      3'UTR
chr12:56864370(+) A-I      3'UTR
chr12:56864208(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SPRYD4
chr12:56864208(+) A-G intron -    22484847
chr12:56864209(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SPRYD4
chr12:56862835-56862836(+) m6A 5'UTR//CDS       24284625//24981863//22608085
chr12:56862848-56862849(+) m6A 5'UTR//CDS       24284625//24981863//22608085
chr12:56862975-56862976(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:56862997-56862998(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:56863059-56863060(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:56863268-56863269(+) m6A 5'UTR//CDS       24284625//25456834//24981863
chr12:56863541-56863542(+) m6A 3'UTR//5'UTR       24284625//24981863
chr12:56863656-56863657(+) m6A 3'UTR//CDS       24284625//24981863
chr12:56872891-56872892(+) m6A 3'UTR       -
chr12:56872915-56872916(+) m6A 3'UTR       -
chr12:56872976-56872977(+) m6A 3'UTR       -
chr12:56873014-56873015(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa_circ_0002248
Exosome Blood     -
SPRYD4
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa_circ_0002248
Interactor2: SPRYD4

Evidence Support:


Weak-Evidence Illumina sequencing
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression None
Description The mRNA-circRNA pairs with strong positive correlations were defined as those having r >0.7 and cP <0.05.

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