Detail Information

Basic Information:


  VIRBase ID:  

HHID00098536

  Virus:  

Middle East respiratory syndrome-related coronavirus (MERS-CoV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa_circ_0002248 PNPLA3
miRBase
Accession/Entrez ID		 hsa_circ_0002248 80339
Organism Homo sapiens Homo sapiens
Category circRNA mRNA
Alias - ADPN//C22orf20//iPLA(2)epsilon

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PNPLA3
chr22:44339877(+) A-I      intronic
chr22:44339826(+) A-I      intronic
chr22:44339808(+) A-I      intronic
chr22:44336609(+) A-I      intronic
chr22:44336585(+) A-I      intronic
chr22:44336550(+) A-I      intronic
chr22:44339786(+) A-I      intronic
chr22:44330076(+) A-I      intronic
chr22:44339795(+) A-I      intronic
chr22:44339755(+) A-I      intronic
chr22:44339738(+) A-I      intronic
chr22:44338700(+) A-I      intronic
chr22:44336809(+) A-I      intronic
chr22:44329463(+) A-I      intronic
chr22:44329367(+) A-I      intronic
chr22:44327541(+) A-I      intronic
chr22:44327538(+) A-I      intronic
chr22:44336638(+) A-I      intronic
chr22:44327530(+) A-I      intronic
chr22:44327525(+) A-I      intronic
chr22:44325078(+) A-I      intronic
chr22:44339852(+) A-I      intronic
chr22:44343077(+) A-I      3'UTR
chr22:44343078(+) A-I      3'UTR
chr22:44343079(+) A-I      3'UTR
chr22:44330177(+) A-I      intronic
chr22:44330176(+) A-I      intronic
chr22:44329488(+) A-I      intronic
chr22:44326896(+) A-I      intronic
chr22:44326886(+) A-I      intronic
chr22:44326818(+) A-I      intronic
chr22:44325338(+) A-I      intronic
chr22:44325235(+) A-I      intronic
chr22:44323284(+) A-I      intronic
chr22:44339928(+) A-I      intronic
chr22:44339834(+) A-I      intronic
chr22:44330179(+) A-I      intronic
chr22:44343100(+) A-I      3'UTR
chr22:44343145(+) A-I      3'UTR
chr22:44343043(+) A-I      3'UTR
chr22:44343038(+) A-I      3'UTR
chr22:44343087(+) A-I      3'UTR
chr22:44343086(+) A-I      3'UTR
chr22:44343057(+) A-I      3'UTR
chr22:44343053(+) A-I      3'UTR
chr22:44336474(+) A-I      intronic
chr22:44336646(+) A-I      intronic
chr22:44325738(+) A-I      intronic
chr22:44336479(+) A-I      intronic
chr22:44336679(+) A-I      intronic
chr22:44338634(+) A-I      intronic
chr22:44339798(+) A-I      intronic
chr22:44336512(+) A-I      intronic
chr22:44343089(+) A-I      3'UTR
chr22:44343196(+) A-I      3'UTR
chr22:44343118(+) A-I      3'UTR
chr22:44343029(+) A-I      3'UTR
chr22:44343088(+) A-I      3'UTR
chr22:44343164(+) A-I      3'UTR
chr22:44342983(+) A-I      3'UTR
chr22:44343062(+) A-I      3'UTR
chr22:44343119(+) A-I      3'UTR
chr22:44343167(+) A-I      3'UTR
chr22:44336920(+) A-I      intronic
chr22:44329489(+) A-I      intronic
chr22:44329336(+) A-I      intronic
chr22:44336433(+) A-I      intronic
chr22:44339888(+) A-I      intronic
chr22:44330152(+) A-I      intronic
chr22:44329493(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PNPLA3
chr22:44329489(+) A-I intron -    21960545
chr22:44329493(+) A-I intron -    21960545
chr22:44329501(+) A-I intron -    21960545
chr22:44336474(+) A-I intron -    21960545
chr22:44343118(+) A-I intron -    21960545
chr22:44343119(+) A-I intron -    21960545
chr22:44343196(+) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PNPLA3
chr22:44319669-44319670(+) m6A 5'UTR       25456834
chr22:44319727-44319728(+) m6A 5'UTR       25456834
chr22:44342086-44342087(+) m6A CDS//intron       24284625
chr22:44342100-44342101(+) m6A CDS//intron       24284625
chr22:44342133-44342134(+) m6A CDS//intron       24284625//25456834
chr22:44342179-44342180(+) m6A CDS//intron       24284625//25456834
chr22:44342557-44342558(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085
chr22:44351380-44351381(+) m6A intron       24284625//24981863
chr22:44351454-44351455(+) m6A intron       24284625//24981863
chr22:44351463-44351464(+) m6A intron       24284625//24981863
chr22:44358981-44358982(+) m6A intron       24981863
chr22:44359059-44359060(+) m6A intron       24981863
chr22:44359093-44359094(+) m6A intron       24981863
chr22:44359098-44359099(+) m6A intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa_circ_0002248
Exosome Blood     -
PNPLA3
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa_circ_0002248
Interactor2: PNPLA3

Evidence Support:


Weak-Evidence Illumina sequencing
Support Database ViRBase

References:


PMID 32223537 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Calu-3 cells Interactor2 expression None
Description The mRNA-circRNA pairs with strong positive correlations were defined as those having r >0.7 and cP <0.05.

Starting a new search, please wait ...