Basic Information:

  VIRBase ID:  

HHID00098225

  Virus:  

Avian infectious bronchitis virus (strain Beaudette)

  Host:  

Gallus gallus

  Confidence Score:  

0.9026

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      gga-miR-146a-5p:  MIMAT0001163          IRAK2:  NM_001030605     

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Interactor Information:

	Interactor1	Interactor2
Symbol	gga-miR-146a-5p	IRAK2
miRBase Accession/Entrez ID	MIMAT0001163	416118
Organism	Gallus gallus	Gallus gallus
Category	miRNA	mRNA
Alias	-	-

Interaction Network (The top 100 interactions):

Interactor1: gga-miR-146a-5p
Interactor2: IRAK2

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//RT-qPCR
Prediction-Evidence	miRanda
Support Database	ViRBase

References:

PMID	29702211	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HD11 cells//HEK 293T cells//Vero cells	Interactor2 expression	Downregulation
Description	IBV induced miR-146a-5p is related to virus pathogenesis by down regulating IRAK2 and TNFRSF18, which may serve as a therapeutic strategy for the prevention of IBV infections.