Detail Information

Basic Information:


  VIRBase ID:  

HHID00098104

  Virus:  

Vesicular stomatitis virus (VSV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-548c-5p:           IFNL1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-548c-5p IFNL1
miRBase
Accession/Entrez ID		 MIMAT0004806 282618
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IL-29//IL29

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-548c-5p
rs1188707087 chr12:64622544    C/A
rs1188707087 chr12:64622544    C/T
rs1371697031 chr12:64622552    G/A
rs1391518567 chr12:64622541    T/C
rs750959106 chr12:64622554    C/T
rs1202383522 chr12:64622535    A/G
rs374151873 chr12:64622540    A/G
rs540698062 chr12:64622545    G/A
rs764336601 chr12:64622536    A/C

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-548c-5p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Urine     -
IFNL1
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-548c-5p
Emodin 3220 Drug interaction    RC00007211
Sorafenib 216239 Drug interaction    RC00007212
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-548c-5p
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-548c-5p
Interactor2: IFNL1

Evidence Support:


Strong-Evidence ELISA//Luciferase reporter assay//qPCR
Support Database ViRBase

References:


PMID 23150165 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line HepG2 cells//PBMCs//RD cells Interactor2 expression None
Description The result showed that the inhibitors of miR-548b-5p, miR-548c-5p, miR-548i, and miR-548j increased the IFN-lambda1 levels (Fig. 3C). These results showed that the endogenous IFN-lambda1 and ISGs were regulated by miR-548. These findings imply that miR-548 and the inhibitors regulate host antiviral response.

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