Basic Information:

  VIRBase ID:  

HHID00097720

  Virus:  

Reticuloendotheliosis Virus (strain SNV)

  Host:  

Gallus gallus

  Confidence Score:  

0.8847

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      gga-miR-1664-3p:  MIMAT0007547          STAT1:  NM_001012914     

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Interactor Information:

	Interactor1	Interactor2
Symbol	gga-miR-1664-3p	STAT1
miRBase Accession/Entrez ID	MIMAT0007547	424044
Organism	Gallus gallus	Gallus gallus
Category	miRNA	mRNA
Alias	-	-

Interaction Network (The top 100 interactions):

Interactor1: gga-miR-1664-3p
Interactor2: STAT1

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	Small RNA sequencing
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	30818863	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	None	Interactor2 expression	Upregulation
Description	We selected immune-related target genes CTLA4, CCR2, CCR4, CCR8, TNFSF6, TNFRSF13C, CLDN5, CLDN11, CASP10, STAT1, MAPK10, RAPGEF4, FOS and JUN for validation. These target genes were regulated by gga-miR200a-3p, gga-miR-375, gga-miR-1458, gga-miR-1664-3p, gga-miR-122-5p, gga-miR-222b-5p, gga-miR-147, gga-miR-1329-5p, gga-miR-1618-5p, gga-miR-1664-3p, gga-miR-146b-3p, gga-miR-222b-3p, gga-miR-144-3p and gga-miR-1769-3p, respectively.