Basic Information:
VIRBase ID:
HHID00097419
Virus:
Reticuloendotheliosis Virus (strain SNV)
Host:
Gallus gallus
Confidence Score:
0.8847
Interaction Type:
Host-Host interaction
Predicted Binding:
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Interactor Information:
|
Interactor1 |
Interactor2 |
Symbol |
gga-miR-375 |
CCR2 |
miRBase Accession/Entrez ID |
MIMAT0003362 |
420696 |
Organism |
Gallus gallus |
Gallus gallus |
Category |
miRNA |
mRNA |
Alias |
-
|
CCR5-L
|
Interaction Network (The top 100 interactions):
Interactor1: gga-miR-375 |
|
Interactor2: CCR2 |
|
Evidence Support:
Strong-Evidence |
qRT-PCR |
Weak-Evidence |
Small RNA sequencing |
Prediction-Evidence |
Targetscan |
Support Database |
ViRBase
|
References:
PMID |
30818863 |
Target region |
None |
Source |
ViRBase
|
Interactor1 expression |
Downregulation |
Tissue or cell line |
None |
Interactor2 expression |
Upregulation |
Description |
We selected immune-related target genes CTLA4, CCR2, CCR4, CCR8, TNFSF6, TNFRSF13C, CLDN5, CLDN11, CASP10, STAT1, MAPK10, RAPGEF4, FOS and JUN for validation. These target genes were regulated by gga-miR200a-3p, gga-miR-375, gga-miR-1458, gga-miR-1664-3p, gga-miR-122-5p, gga-miR-222b-5p, gga-miR-147, gga-miR-1329-5p, gga-miR-1618-5p, gga-miR-1664-3p, gga-miR-146b-3p, gga-miR-222b-3p, gga-miR-144-3p and gga-miR-1769-3p, respectively. |