Basic Information:

  VIRBase ID:  

HHID00096614

  Virus:  

Moloney murine leukemia virus neuropathogenic variant ts1-92b

  Host:  

Mus musculus

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-20b-5p:  MIMAT0003187          Vegfa:  NM_001025250     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-20b-5p	Vegfa
miRBase Accession/Entrez ID	MIMAT0003187	22339
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	V//Veg//Vegf//VEGF12//VEGF16//VEGF18//Vpf

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Vegfa	chr17:46017264-46017265(-) Y 3'UTR//exon       26075521 chr17:46017598-46017599(-) Y 3'UTR//exon       26075521 chr17:46017674-46017675(-) m6A 3'UTR       24981863//25569111 chr17:46017762-46017763(-) m6A 3'UTR       25456834//24981863//25569111 chr17:46017833-46017834(-) m6A 3'UTR       25456834//25412662//24981863//25569111//22608085//22575960 chr17:46017856-46017857(-) m6A 3'UTR       25456834//25412662//24981863//25569111//22608085//22575960 chr17:46017865-46017866(-) m6A 3'UTR       25456834//25412662//24981863//25569111//22608085//22575960 chr17:46017880-46017881(-) m6A 3'UTR       25456834//25412662//24981863//25569111//22608085//22575960 chr17:46017928-46017929(-) m6A 3'UTR       25456834//25412662//24981863//25569111 chr17:46017974-46017975(-) m6A 3'UTR       25456834//25412662//24981863//25569111//22608085 chr17:46018130-46018131(-) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46018194-46018195(-) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46018202-46018203(-) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46018229-46018230(-) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46018238-46018239(-) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46018346-46018347(-) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46018393-46018394(-) m6A 3'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46018542-46018543(-) m6A 3'UTR//exon       25683224//25456834//24981863//25569111//22608085//22575960 chr17:46018621-46018622(-) m6A 3'UTR//exon       25683224//25456834//25412662//24981863//25569111//26404942//22608085//22575960 chr17:46018672-46018673(-) m6A 3'UTR//exon       25683224//25456834//25412662//24981863//25569111//26404942//22608085//22575960 chr17:46018707-46018708(-) m6A 3'UTR//exon       25683224//25456834//25412662//24981863//25569111//26404942//22608085//22575960 chr17:46018748-46018749(-) m6A 3'UTR//exon       25683224//25412662//24981863//25569111//26404942//22608085//22575960 chr17:46018796-46018797(-) m6A 3'UTR//exon       25412662//24981863//25569111//22608085 chr17:46018812-46018813(-) m6A 3'UTR//exon       25412662//24981863//25569111 chr17:46018817-46018818(-) m6A 3'UTR//exon       25412662//24981863//25569111 chr17:46021038-46021039(-) m6A CDS//exon//intron       25412662//24981863//25569111 chr17:46021044-46021045(-) m6A CDS//exon//intron       25412662//25569111 chr17:46024077-46024078(-) m6A CDS//exon       25412662//24981863//25569111 chr17:46024082-46024083(-) m6A CDS//exon       25412662//24981863//25569111//22608085 chr17:46024505-46024506(-) m6A CDS//exon       25412662//24981863//22608085 chr17:46024615-46024616(-) m6A exon//intron       25412662 chr17:46024775-46024776(-) m6A exon//intron       25412662 chr17:46025243-46025244(-) m6A exon//intron       25412662 chr17:46025295-46025296(-) m6A exon//intron       25412662//22608085 chr17:46025482-46025483(-) m6A CDS//exon       25683224//25412662//25569111//22608085 chr17:46025492-46025493(-) m6A CDS//exon       25683224//25412662//24981863//25569111//22608085 chr17:46031325-46031326(-) m6A CDS//exon       25683224//25412662//24981863//25569111 chr17:46031351-46031352(-) m6A CDS//exon       25683224//25412662//24981863//25569111 chr17:46031358-46031359(-) m6A 5'UTR//CDS       25683224//25412662//24981863//25569111 chr17:46031513-46031514(-) m6A 5'UTR//CDS       25683224//25456834//25412662//24981863//25569111 chr17:46031672-46031673(-) m6A 5'UTR//CDS       25683224//25456834//25412662//24981863//25569111 chr17:46031734-46031735(-) m6A 5'UTR//CDS       25683224//25456834//25412662//24981863//25569111 chr17:46031794-46031795(-) m6A 5'UTR//CDS       25683224//25456834//25412662//24981863//25569111 chr17:46031874-46031875(-) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46031882-46031883(-) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46031899-46031900(-) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46031981-46031982(-) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46031993-46031994(-) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111//22608085//22575960 chr17:46032023-46032024(-) m6A 5'UTR       25683224//25456834//25412662//24981863//25569111//22608085 chr17:46032195-46032196(-) m6A 5'UTR       25456834//25412662//24981863//25569111 chr17:46032218-46032219(-) m6A 5'UTR       25456834//25412662//24981863//25569111 chr17:46032261-46032262(-) m6A 5'UTR       25412662//24981863//25569111//22575960 chr17:46032273-46032274(-) m6A 5'UTR       25412662//24981863//25569111//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-20b-5p	Exosome B6 BMDCs     22031862 Exosome Bone marrow-derived macrophages     25159140
	Vegfa	Nucleus Neuroblastoma cell line (N2A)     22406755 Nucleus Neuroblastoma cell line (N2A)     22406755 Nucleus Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-20b-5p
Interactor2: Vegfa

Evidence Support:

Strong-Evidence	RT-PCR
Weak-Evidence	MiRNA microarray
Support Database	ViRBase

References:

PMID	20201611	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Mice brainstem tissue	Interactor2 expression	Upregulation
Description	Using these data, we analyzed the expression of miRNA-20a and miRNA-20b in relation to VEGF expression levels in brainstems of the uninfected, ts1-infected, uninfected GVT-treated and ts1-infected GVT-treated mice. ts1-infected brainstems showed an upregulation of miRNA-20a and miRNA-20b compared with the brainstems of uninfected mice (Fig. 3c, d).