Detail Information

Basic Information:


  VIRBase ID:  

HHID00096602

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-150-3p:           CCR5:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-150-3p CCR5
miRBase
Accession/Entrez ID		 MIMAT0004610 1234
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CC-CKR-5//CCCKR5//CCR-5//CD195//CKR-5//CKR5//CMKBR5//IDDM22

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-150-3p
rs1222701309 chr19:49500798    T/C
rs1268655804 chr19:49500801    C/T
rs1479556921 chr19:49500803    C/A
rs900688289 chr19:49500802    C/T
rs1184577625 chr19:49500811    T/C
rs1270941119 chr19:49500816    C/T
rs1413039185 chr19:49500817    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCR5
chr3:46417215(+) A-I      3'UTR
chr3:46417221(+) A-I      3'UTR
chr3:46417219(+) A-I      3'UTR
chr3:46417218(+) A-I      3'UTR
chr3:46417270(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CCR5
chr3:46417171(+) A-I exon 3'UTR    15258596
chr3:46417220(+) A-I exon 3'UTR    15258596
chr3:46417272(+) A-I exon 3'UTR    15258596
chr3:46417283(+) A-I exon 3'UTR    15258596

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCR5
chr3:46414562-46414563(+) m6A CDS       -
chr3:46414676-46414677(+) m6A CDS       -
chr3:46415165-46415166(+) m6A CDS       -
chr3:46415219-46415220(+) m6A CDS       -
chr3:46415242-46415243(+) m6A CDS       -
chr3:46415309-46415310(+) m6A CDS       -
chr3:46415457-46415458(+) m6A 3'UTR       -
chr3:46416453-46416454(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-150-3p
Exosome Saliva     19627513
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
CCR5
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-150-3p
Ginsenoside Rh2 119307 Drug interaction    RC00006970
Androstanolone 10635 Drug interaction    RC00006969
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-150-3p
Imatinib 5291       25349971

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-150-3p
Interactor2: CCR5

Evidence Support:


Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 22936931 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line CD4(+) T cells Interactor2 expression Downregulation
Description Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions.Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products.

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