Basic Information:

  VIRBase ID:  

HHID00096598

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-28-3p:  MIMAT0004502          CCR5:  NM_000579     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-28-3p	CCR5
miRBase Accession/Entrez ID	MIMAT0004502	1234
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CC-CKR-5//CCCKR5//CCR-5//CD195//CKR-5//CKR5//CMKBR5//IDDM22

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-28-3p	rs1171800557 chr3:188688855    A/C rs1204710407 chr3:188688834    C/T rs1403809755 chr3:188688851    C/T rs368910045 chr3:188688843    G/C rs368910045 chr3:188688843    G/T rs375704067 chr3:188688850    C/T rs750403936 chr3:188688844    T/G rs758203780 chr3:188688847    G/A rs78547906 chr3:188688848    C/T rs1239471924 chr3:188688836    C/A rs778663459 chr3:188688841    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCR5	chr3:46417215(+) A-I      3'UTR chr3:46417221(+) A-I      3'UTR chr3:46417219(+) A-I      3'UTR chr3:46417218(+) A-I      3'UTR chr3:46417270(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCR5	chr3:46417171(+) A-I exon 3'UTR    15258596 chr3:46417220(+) A-I exon 3'UTR    15258596 chr3:46417272(+) A-I exon 3'UTR    15258596 chr3:46417283(+) A-I exon 3'UTR    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCR5	chr3:46414562-46414563(+) m6A CDS       - chr3:46414676-46414677(+) m6A CDS       - chr3:46415165-46415166(+) m6A CDS       - chr3:46415219-46415220(+) m6A CDS       - chr3:46415242-46415243(+) m6A CDS       - chr3:46415309-46415310(+) m6A CDS       - chr3:46415457-46415458(+) m6A 3'UTR       - chr3:46416453-46416454(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-28-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Plasma     23663360 Exosome Blood|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Neural progenitor cells     21363885
	CCR5	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-28-3p	Doxorubicin 31703       25698578

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-28-3p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Paclitaxel       36314 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-28-3p
Interactor2: CCR5

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

[1]PMID	19443673	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	CD4(+) T cells	Interactor2 expression	Downregulation
Description	Swaminathan et al(1) stated that despite the higher levels of anti-HIV microRNAs (miRNAs) in monocytes, there is no demonstration in our paper that the low-level expression of both HIV-1 primary receptor CD4 and coreceptor CCR5 on monocytes is not the more significant factor contributing to monocytes' resistance to infection.

[2]PMID	22936931	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	CD4(+) T cells	Interactor2 expression	Downregulation
Description	Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions.Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products.