Basic Information:

  VIRBase ID:  

HHID00096597

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-382-5p:  MIMAT0000737          TLR3:  NM_003265     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-382-5p	TLR3
miRBase Accession/Entrez ID	MIMAT0000737	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-382-5p	rs752396166 chr14:101054326    G/A rs762649016 chr14:101054336    C/G rs762649016 chr14:101054336    C/T rs764006384 chr14:101054337    G/A rs764920693 chr14:101054325    C/T rs192719529 chr14:101054320    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-382-5p	Exosome Serum     18589210 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Blood     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Seminal plasma     23539611 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-382-5p	3-Deazacytidine 97577 Drug resistant 8-Aminoadenosine 96851 Drug resistant 1H-Pyrazolo[3,4-d]pyrimidin-4-amine 75420 Drug resistant Berberine iodide 72350 Drug sensitive 1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant Silver mesylate 6712944 Drug resistant Pyrazolo[1,5-b]pyridazine deriv. 97 6539439 Drug resistant 3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive 2-Azaadenine 5480214 Drug resistant 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive 5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one 5477132 Drug resistant Tetrocarcin A, sodium salt 54724658 Drug sensitive 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive [(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant Varacin trifluoroacetate salt 54611558 Drug resistant 2-Methylolivacinium acetate 5458752 Drug sensitive Xestin A 5352066 Drug resistant Berberal 5351462 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Eupachlorin 5281446 Drug resistant 6-Bromosangivamycin 470030 Drug resistant Justicidin B 442882 Drug resistant Suavedol 442245 Drug resistant Musennin 441933 Drug sensitive Isobrucein A 441802 Drug sensitive Antibiotic X-14766A 434840 Drug sensitive Elliptinium acetate 42722 Drug sensitive Antineoplastic-D648114 372647 Drug sensitive 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive 1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant Haloprogin 3561 Drug resistant Maxima isoflavone D 343081 Drug sensitive Ellipticine 3213 Drug sensitive 8-Trichloromethyldihydroberberine 320713 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive 4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant Sarcoviolin 24202820 Drug sensitive Sodium 2-(4-((7-chloro-2-quinoxalinyl)oxy)phenoxy)propionate 23675947 Drug sensitive 2-Bromo-4-methyl-1,3,5-trinitrobenzene 219376 Drug resistant Kinetin riboside 20345 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant {4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine 17892742 Drug resistant Paucin 161538 Drug resistant [(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant (1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant Methyl ester prodigiosene 136040158 Drug resistant Formycin b 135449281 Drug resistant Salicylidene salicylhydrazide 135445765 Drug resistant Allopurinol 135401907 Drug resistant 43-Dioxypectenotoxin 131751434 Drug sensitive (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive 15-Deacetylsergeolide 125729 Drug sensitive Berberine chloride 12456 Drug sensitive Litmomycin 12310334 Drug resistant 3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant Unii-9JU14BJ5QG 109374088 Drug sensitive 2,9-Dimethylellipticinium acetate 10472068 Drug sensitive 2-N-Methyl-6-oxaellipticinium acetate 10018975 Drug sensitive 1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant bafilomycin antibiotic - Drug resistant granatomycin a - Drug resistant o-linoleoyl-2-butoxy-1-desoamine - Drug resistant N-(benzo[d]thiazol-2-yl)-2-phenyl-7-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide - Drug sensitive naphtho[1,2-b]quinolizinium, 9-methyl-, bromide - Drug sensitive phosphonium, 1,8-octanediylbis[triphenyl-, diiodide - Drug sensitive phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 2-methylellpticinium - Drug sensitive chrysarobin - Drug sensitive protein: pahiv4 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-382-5p	Vorinostat 5311 Drug interaction    RC00004261 Eloxatine 5310940 Drug interaction    RC00004266 Morphine 5288826 Drug interaction    RC00004265 Etoposide 36462 Drug interaction    RC00004263 Doxorubicin 31703 Drug interaction    RC00004262 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004260 Methotrexate 126941 Drug interaction    RC00004264 Rituximab - Drug interaction    RC00004267

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-382-5p
Interactor2: TLR3

Evidence Support:

Strong-Evidence	qRT-PCR
Support Database	ViRBase

References:

PMID	20636339	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	CD4(+) T cells	Interactor2 expression	None
Description	Further more, TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. TLR-3 activation inhibits HIV-1 infection of macrophages