Basic Information:

  VIRBase ID:  

HHID00096580

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9489

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7g-5p:  MIMAT0000414          IL10:  NR_168467     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-let-7g-5p	IL10
miRBase Accession/Entrez ID	MIMAT0000414	3586
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CSIF//GVHDS//IL-10//IL10A//TGIF

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL10	chr1:206941331(-) A-I      3'UTR

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-let-7g-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm HeLa cells     22058130 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Epidermal melanocytes (HEMa-LP)|Malignant melanoma cell line (A375)     23056502 Exosome Saliva     23302638 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     19002258 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Hepatoma cells     23771658 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686 Mitochondrion HEK-293 cells|HeLa cells|Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa cells     22058130
	IL10	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-let-7g-5p	1H-Indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 Drug resistant

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-let-7g-5p	10-Hydroxycamptothecin 97226 Drug interaction    RC00002386 Formaldehyde 712 Drug interaction    RC00002374 Oxaliplatine 6857599 Drug interaction    RC00002388 Bisphenol A 6623 Drug interaction    RC00002379 Estradiol 5757 Drug interaction    RC00002378 Decitabine 451668 Drug interaction    RC00002387 Carboplatinum 38904 Drug interaction    RC00002385 Etoposide 36462 Drug interaction    RC00002384 Paclitaxel 36314 Drug interaction    RC00002383 5-Fluorouracil 3385 Drug interaction    RC00002377 Doxorubicin 31703 Drug interaction    RC00002382 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002376 Verapamil 2520 Drug interaction    RC00002375 Arsenic trioxide 14888 Drug interaction    RC00002381 Leucovorin 135403648 Drug interaction    RC00002389 Vinblastine 13342 Drug interaction    RC00002380 modified ALLIC BFM 2002 protocol - Drug interaction    RC00002390 Marine fungal metabolite 1386A - Drug interaction    RC00002391 Chemotherapy - Drug interaction    RC00008839

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-let-7g-5p	Paclitaxel 36314       26323677 Platinum 23939       25872328

Interaction Network (The top 100 interactions):

Interactor1: hsa-let-7g-5p
Interactor2: IL10

Evidence Support:

Strong-Evidence	Luciferase reporter assay//RT-PCR
Weak-Evidence	Microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

[1]PMID	22586040	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HeLa cells//HUT78 cells	Interactor2 expression	Downregulation
Description	Our initial in vitro studies demonstrated that HIV-1-infected HUT78 cells expressed significantly higher IL-10 levels compared with uninfected cultures. IL-10 plays an important role in the dysregulated cytotoxic T cell response to HIV-1, and in silico algorithms suggested that let-7 miRNAs target IL10 mRNA.

[2]PMID	22936931	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HeLa cells//HUT78 cells	Interactor2 expression	Downregulation
Description	Table2 summarizes the list of cellular microRNAs with their validated host cellular protein targets and their corresponding cellular functions.Table 2 List of published cellular microRNAs and their target HIV-1 and cellular gene products.