Detail Information

Basic Information:


  VIRBase ID:  

HHID00096573

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9806

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-198:           CCNT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-198 CCNT1
miRBase
Accession/Entrez ID		 MIMAT0000228 904
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CCNT//CYCT1//HIVE1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-198
rs1246285223 chr3:120395704    A/T
rs142303836 chr3:120395711    C/T
rs1461187438 chr3:120395710    T/C
rs1184386288 chr3:120395718    C/T
rs983004299 chr3:120395722    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCNT1
chr12:49090783(-) A-I      intronic
chr12:49090835(-) A-I      intronic
chr12:49090772(-) A-I      intronic
chr12:49090712(-) A-I      intronic
chr12:49091140(-) A-I      intronic
chr12:49091038(-) A-I      intronic
chr12:49095899(-) A-I      intronic
chr12:49090821(-) A-I      intronic
chr12:49095859(-) A-I      intronic
chr12:49095850(-) A-I      intronic
chr12:49090818(-) A-I      intronic
chr12:49107970(-) A-I      intronic
chr12:49107949(-) A-I      intronic
chr12:49107909(-) A-I      intronic
chr12:49090794(-) A-I      intronic
chr12:49106697(-) A-I      intronic
chr12:49106506(-) A-I      intronic
chr12:49105806(-) A-I      intronic
chr12:49105782(-) A-I      intronic
chr12:49105780(-) A-I      intronic
chr12:49105714(-) A-I      intronic
chr12:49105668(-) A-I      intronic
chr12:49105681(-) A-I      intronic
chr12:49105111(-) A-I      intronic
chr12:49105106(-) A-I      intronic
chr12:49105023(-) A-I      intronic
chr12:49105006(-) A-I      intronic
chr12:49105000(-) A-I      intronic
chr12:49104838(-) A-I      intronic
chr12:49104700(-) A-I      intronic
chr12:49103842(-) A-I      intronic
chr12:49103726(-) A-I      intronic
chr12:49105141(-) A-I      intronic
chr12:49102756(-) A-I      intronic
chr12:49101330(-) A-I      intronic
chr12:49099023(-) A-I      intronic
chr12:49098509(-) A-I      intronic
chr12:49098480(-) A-I      intronic
chr12:49098409(-) A-I      intronic
chr12:49097474(-) A-I      intronic
chr12:49096624(-) A-I      intronic
chr12:49096419(-) A-I      intronic
chr12:49103034(-) A-I      intronic
chr12:49095752(-) A-I      intronic
chr12:49095727(-) A-I      intronic
chr12:49090795(-) A-I      intronic
chr12:49095721(-) A-I      intronic
chr12:49090771(-) A-I      intronic
chr12:49095718(-) A-I      intronic
chr12:49095571(-) A-I      intronic
chr12:49096402(-) A-I      intronic
chr12:49096578(-) A-I      intronic
chr12:49095443(-) A-I      intronic
chr12:49096394(-) A-I      intronic
chr12:49091545(-) A-I      intronic
chr12:49096383(-) A-I      intronic
chr12:49103741(-) A-I      intronic
chr12:49107364(-) A-I      intronic
chr12:49099350(-) A-I      intronic
chr12:49102803(-) A-I      intronic
chr12:49107400(-) A-I      intronic
chr12:49099288(-) A-I      intronic
chr12:49107969(-) A-I      intronic
chr12:49100769(-) A-I      intronic
chr12:49091098(-) A-I      intronic
chr12:49103819(-) A-I      intronic
chr12:49106104(-) A-I      intronic
chr12:49096788(-) A-I      intronic
chr12:49091223(-) A-I      intronic
chr12:49104681(-) A-I      intronic
chr12:49090777(-) A-I      intronic
chr12:49091555(-) A-I      intronic
chr12:49090681(-) A-I      intronic
chr12:49099255(-) A-I      intronic
chr12:49096760(-) A-I      intronic
chr12:49107321(-) A-I      intronic
chr12:49090754(-) A-I      intronic
chr12:49090789(-) A-I      intronic
chr12:49105087(-) A-I      intronic
chr12:49090792(-) A-I      intronic
chr12:49102669(-) A-I      intronic
chr12:49099268(-) A-I      intronic
chr12:49104991(-) A-I      intronic
chr12:49102798(-) A-I      intronic
chr12:49099335(-) A-I      intronic
chr12:49090751(-) A-I      intronic
chr12:49104687(-) A-I      intronic
chr12:49096724(-) A-I      intronic
chr12:49091046(-) A-I      intronic
chr12:49099275(-) A-I      intronic
chr12:49101344(-) A-I      intronic
chr12:49107533(-) A-I      intronic
chr12:49106166(-) A-I      intronic
chr12:49103813(-) A-I      intronic
chr12:49090701(-) A-I      intronic
chr12:49107499(-) A-I      intronic
chr12:49090796(-) A-I      intronic
chr12:49101815(-) A-I      intronic
chr12:49095621(-) A-I      intronic
chr12:49096721(-) A-I      intronic
chr12:49102813(-) A-I      intronic
chr12:49091533(-) A-I      intronic
chr12:49090799(-) A-I      intronic
chr12:49107498(-) A-I      intronic
chr12:49095952(-) A-I      intronic
chr12:49107422(-) A-I      intronic
chr12:49095858(-) A-I      intronic
chr12:49106601(-) A-I      intronic
chr12:49090688(-) A-I      intronic
chr12:49106228(-) A-I      intronic
chr12:49106306(-) A-I      intronic
chr12:49097462(-) A-I      intronic
chr12:49097659(-) A-I      intronic
chr12:49097668(-) A-I      intronic
chr12:49091553(-) A-I      intronic
chr12:49105628(-) A-I      intronic
chr12:49107910(-) A-I      intronic
chr12:49090810(-) A-I      intronic
chr12:49097488(-) A-I      intronic
chr12:49101267(-) A-I      intronic
chr12:49095476(-) A-I      intronic
chr12:49090744(-) A-I      intronic
chr12:49090829(-) A-I      intronic
chr12:49091099(-) A-I      intronic
chr12:49090830(-) A-I      intronic
chr12:49095463(-) A-I      intronic
chr12:49095817(-) A-I      intronic
chr12:49107745(-) A-I      intronic
chr12:49101342(-) A-I      intronic
chr12:49106230(-) A-I      intronic
chr12:49107090(-) A-I      intronic
chr12:49105062(-) A-I      intronic
chr12:49091137(-) A-I      intronic
chr12:49103770(-) A-I      intronic
chr12:49090793(-) A-I      intronic
chr12:49090854(-) A-I      intronic
chr12:49104809(-) A-I      intronic
chr12:49099329(-) A-I      intronic
chr12:49106196(-) A-I      intronic
chr12:49091414(-) A-I      intronic
chr12:49091186(-) A-I      intronic
chr12:49107788(-) A-I      intronic
chr12:49091100(-) A-I      intronic
chr12:49091436(-) A-I      intronic
chr12:49095975(-) A-I      intronic
chr12:49096652(-) A-I      intronic
chr12:49096658(-) A-I      intronic
chr12:49105608(-) A-I      intronic
chr12:49107375(-) A-I      intronic
chr12:49090708(-) A-I      intronic
chr12:49107323(-) A-I      intronic
chr12:49091304(-) A-I      intronic
chr12:49096517(-) A-I      intronic
chr12:49103956(-) A-I      intronic
chr12:49095898(-) A-I      intronic
chr12:49090721(-) A-I      intronic
chr12:49090785(-) A-I      intronic
chr12:49090287(-) A-I      intronic
chr12:49101678(-) A-I      intronic
chr12:49095592(-) A-I      intronic
chr12:49107349(-) A-I      intronic
chr12:49107890(-) A-I      intronic
chr12:49106197(-) A-I      intronic
chr12:49106684(-) A-I      intronic
chr12:49097304(-) A-I      intronic
chr12:49106244(-) A-I      intronic
chr12:49097597(-) A-I      intronic
chr12:49105149(-) A-I      intronic
chr12:49095486(-) A-I      intronic
chr12:49091439(-) A-I      intronic
chr12:49107357(-) A-I      intronic
chr12:49096548(-) A-I      intronic
chr12:49098583(-) A-I      intronic
chr12:49090820(-) A-I      intronic
chr12:49106183(-) A-I      intronic
chr12:49090849(-) A-I      intronic
chr12:49105063(-) A-I      intronic
chr12:49091526(-) A-I      intronic
chr12:49101298(-) A-I      intronic
chr12:49098404(-) A-I      intronic
chr12:49088642(-) A-I      intronic
chr12:49088673(-) A-I      intronic
chr12:49102777(-) A-I      intronic
chr12:49091490(-) A-I      intronic
chr12:49097112(-) A-I      intronic
chr12:49095487(-) A-I      intronic
chr12:49106108(-) A-I      intronic
chr12:49102808(-) A-I      intronic
chr12:49091183(-) A-I      intronic
chr12:49091550(-) A-I      intronic
chr12:49096804(-) A-I      intronic
chr12:49107362(-) A-I      intronic
chr12:49099328(-) A-I      intronic
chr12:49104704(-) A-I      intronic
chr12:49096749(-) A-I      intronic
chr12:49102859(-) A-I      intronic
chr12:49107363(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CCNT1
chr12:49090799(-) A-I intron -    22327324
chr12:49090688(-) A-G intron -    22484847
chr12:49090751(-) A-G intron -    22484847
chr12:49090793(-) A-G intron -    22484847
chr12:49090796(-) A-G intron -    22484847
chr12:49090799(-) A-G intron -    22484847
chr12:49090820(-) A-G intron -    22484847
chr12:49090829(-) A-G intron -    22484847
chr12:49107788(-) A-G intron -    22484847
chr12:49090701(-) A-G intron -    22484847
chr12:49090754(-) A-G intron -    22484847
chr12:49090777(-) A-G intron -    22484847
chr12:49090792(-) A-G intron -    22484847
chr12:49091100(-) A-G intron -    22484847
chr12:49091304(-) A-G intron -    22484847
chr12:49091414(-) A-G intron -    22484847
chr12:49091436(-) A-G intron -    22484847
chr12:49091439(-) A-G intron -    22484847
chr12:49091526(-) A-G intron -    22484847
chr12:49091533(-) A-G intron -    22484847
chr12:49091550(-) A-G intron -    22484847
chr12:49091553(-) A-G intron -    22484847
chr12:49091555(-) A-G intron -    22484847
chr12:49095117(-) G-A intron -    22484847
chr12:49095797(-) T-C intron -    22484847
chr12:49095817(-) A-G intron -    22484847
chr12:49095858(-) A-G intron -    22484847
chr12:49095943(-) A-C intron -    22484847
chr12:49095975(-) A-G intron -    22484847
chr12:49096517(-) A-G intron -    22484847
chr12:49096548(-) A-G intron -    22484847
chr12:49096652(-) A-G intron -    22484847
chr12:49096658(-) A-G intron -    22484847
chr12:49096749(-) A-G intron -    22484847
chr12:49096760(-) A-G intron -    22484847
chr12:49097112(-) A-G intron -    22484847
chr12:49099329(-) A-G intron -    22484847
chr12:49099335(-) A-G intron -    22484847
chr12:49101342(-) A-G intron -    22484847
chr12:49101344(-) A-G intron -    22484847
chr12:49102777(-) A-G intron -    22484847
chr12:49102813(-) A-G intron -    22484847
chr12:49102859(-) A-G intron -    22484847
chr12:49103741(-) A-G intron -    22484847
chr12:49103813(-) A-G intron -    22484847
chr12:49103819(-) A-G intron -    22484847
chr12:49103956(-) A-G intron -    22484847
chr12:49104681(-) A-G intron -    22484847
chr12:49104687(-) A-G intron -    22484847
chr12:49104704(-) A-G intron -    22484847
chr12:49104991(-) A-G intron -    22484847
chr12:49105062(-) A-G intron -    22484847
chr12:49105063(-) A-G intron -    22484847
chr12:49105087(-) A-G intron -    22484847
chr12:49105149(-) A-G intron -    22484847
chr12:49106108(-) A-G intron -    22484847
chr12:49106196(-) A-G intron -    22484847
chr12:49106197(-) A-G intron -    22484847
chr12:49106244(-) A-G intron -    22484847
chr12:49107349(-) A-G intron -    22484847
chr12:49107357(-) A-G intron -    22484847
chr12:49107362(-) A-G intron -    22484847
chr12:49107364(-) A-G intron -    22484847
chr12:49107498(-) A-G intron -    22484847
chr12:49107745(-) A-G intron -    22484847
chr12:49107890(-) A-G intron -    22484847
chr12:49107910(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCNT1
chr12:49082618-49082619(-) m6A 3'UTR       27773535
chr12:49082634-49082635(-) m6A 3'UTR       27773535
chr12:49082671-49082672(-) m6A 3'UTR       27773535
chr12:49082918-49082919(-) m6A 3'UTR       24981863
chr12:49086391-49086392(-) m6A 3'UTR       24981863//27773535//22608085
chr12:49086463-49086464(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr12:49086568-49086569(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr12:49086686-49086687(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr12:49086710-49086711(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr12:49086746-49086747(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr12:49086774-49086775(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:49086788-49086789(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:49086848-49086849(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr12:49086879-49086880(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr12:49087020-49087021(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:49087029-49087030(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:49087036-49087037(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:49087082-49087083(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:49087102-49087103(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:49087140-49087141(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr12:49087258-49087259(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr12:49087271-49087272(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr12:49087324-49087325(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr12:49087345-49087346(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr12:49087358-49087359(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr12:49087380-49087381(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr12:49087462-49087463(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr12:49087503-49087504(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr12:49087568-49087569(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr12:49087624-49087625(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr12:49087659-49087660(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr12:49087770-49087771(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085
chr12:49087945-49087946(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr12:49087964-49087965(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr12:49087970-49087971(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr12:49088118-49088119(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085
chr12:49088152-49088153(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085
chr12:49088164-49088165(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085
chr12:49088176-49088177(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085
chr12:49088197-49088198(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085
chr12:49089576-49089577(-) m6A 3'UTR//CDS//exon       24284625//27773535//27371828//22608085
chr12:49089610-49089611(-) m6A CDS//exon       24284625//27773535//27371828
chr12:49091945-49091946(-) m6A CDS       27773535
chr12:49091956-49091957(-) m6A CDS       27773535
chr12:49093615-49093616(-) m6A CDS       27773535
chr12:49094801-49094802(-) m6A CDS       27773535
chr12:49110318-49110319(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:49110356-49110357(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:49110369-49110370(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:49110407-49110408(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr12:49110438-49110439(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-198
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Primary T lymphocytes     24356509
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
Mitochondrion Liver tissue     27396686
Mitochondrion Liver cells     19106625
Nucleus Nasopharyngeal carcinoma cells     20498841
CCNT1
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-198
Interactor2: CCNT1

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//RT-PCR//Western blot
Weak-Evidence Microarray
Prediction-Evidence MicroInspector//RNAHybrid
Support Database ViRBase

References:


[1]PMID 19148268 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293T cells//BOSC cells//Hela cells//MM6 cells Interactor2 expression Downregulation
Description We identified a microRNA (miRNA) named miR-198 that represses the expression of Cyclin T1 in monocytes. miRNAs block expression of proteins by binding to messenger RNAs and preventing their translation by ribosomes.
[2]PMID 22936931 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293T cells//BOSC cells//Hela cells//MM6 cells Interactor2 expression Downregulation
Description Another is hsa-miR-198 targeting CCNT1 (Kaul et al., 2009), a key component in the Tat-mediated transcription of the virus, when suppressed can impair HIV-1 replication (Imai et al., 2009).
[3]PMID 23043098 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293T cells//BOSC cells//Hela cells//MM6 cells Interactor2 expression Downregulation
Description For instance, Sung and Rice (43) found that miR-198 targets the cyclin T1 mRNA, which encodes a HIV-1 Tat cofactor, to confer differences in permissiveness between monocytes and macrophages to HIV infection. They also found that, in different cellular contexts, other miRNAs regulate cyclin T1 (e.g. miR-27b, miR-29b, miR-223, and miR-150), potentially explaining expression differences of HIV in resting versus activated T cells (44).
[4]PMID 21569500 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line 293T cells//BOSC cells//Hela cells//MM6 cells Interactor2 expression Downregulation
Description Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. On the other hand, the level of hsa-miR-198, which targets cyclin T1 [The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control62], is upregulated by all three HIV-1NL4-3 strains tested in this study. Cyclin T1 also acts as a cofactor for Tat transcriptional trans-activation, and upregulation of hsa-miR-198 could reduce cyclin T1 levels.

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