Basic Information:

  VIRBase ID:  

HHID00096566

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-28-5p:  MIMAT0000085          TLR3:  NM_003265     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-28-5p	TLR3
miRBase Accession/Entrez ID	MIMAT0000085	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-28-5p	rs1211406812 chr3:188688805    A/T rs1315387654 chr3:188688811    T/G rs1333243027 chr3:188688802    C/A rs1350747725 chr3:188688807    T/C rs1380324091 chr3:188688806    G/A rs1380847802 chr3:188688813    G/GGGAA rs564264103 chr3:188688810    A/G rs1466099417 chr3:188688800    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-28-5p	Cytoplasm Neural progenitor cells     21363885 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Seminal fluid     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-28-5p	Kinetin riboside 20345 Drug resistant michicarcin - Drug resistant

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-28-5p	Formaldehyde 712 Drug interaction    RC00000838 Gemcitabine 60750 Drug interaction    RC00000844 Morphine 5288826 Drug interaction    RC00000848 Cholecalciferol 5280795 Drug interaction    RC00000847 Decitabine 451668 Drug interaction    RC00000846 Epirubicin 41867 Drug interaction    RC00000843 Paclitaxel 36314 Drug interaction    RC00000842 Doxorubicin 31703 Drug interaction    RC00000841 Verapamil 2520 Drug interaction    RC00000839 Ginsenoside Rh2 119307 Drug interaction    RC00000845 Methamphetamine 10836 Drug interaction    RC00000840 Trastuzumab - Drug interaction    RC00000849

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-28-5p	Imatinib 5291       30249101

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-28-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Paclitaxel       36314 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-28-5p
Interactor2: TLR3

Evidence Support:

Strong-Evidence	qRT-PCR
Support Database	ViRBase

References:

PMID	20636339	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	CD4(+) T cells	Interactor2 expression	None
Description	Further more, TLR-3 activation in macrophages induced the expression of cellular microRNAs(miRNA-28, -125b, -150, -223 and -382), the newly identified intracellular HIV restriction factors. TLR-3 activation inhibits HIV-1 infection of macrophages