Basic Information:

  VIRBase ID:  

HHID00096550

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   APOBEC3H:  NP_001159475     

Interactor Information:

	Interactor1	Interactor2
Symbol	7SL	APOBEC3H
miRBase Accession/Entrez ID	7SL	164668
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	protein
Alias	-	A3H//ARP-10//ARP10

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APOBEC3H	chr22:39494475(+) A-I      intronic chr22:39495015(+) A-I      intronic chr22:39500032(+) A-I      3'UTR chr22:39499082(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APOBEC3H	chr22:39499746-39499747(+) m6A 3'UTR       - chr22:39499896-39499897(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	APOBEC3H	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: 7SL
Interactor2: APOBEC3H

Evidence Support:

Strong-Evidence	IP//qRT-PCR//Western blot
Support Database	ViRBase

References:

PMID	22859935	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	293T cells//Hela cells//MAGI-CCR5 cells	Interactor2 expression	Downregulation
Description	Like A3G, A3H HapII also demonstrated high binding affinity to host small RNAs such as 7SL and Y RNAs. Mutation of a critical amino acid, W115A resulted in reduced expression level, decreased affinity for 7SL RNA, impairment of virion packaging and reduced anti-viral activity.