Basic Information:

  VIRBase ID:  

HHID00096531

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-210-5p:  MIMAT0026475          MIDN:  NM_177401     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-210-5p	MIDN
miRBase Accession/Entrez ID	MIMAT0026475	90007
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Stx

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-210-5p	rs1307849834 chr11:568150    C/T rs1328893125 chr11:568155    T/A rs1339953548 chr11:568159    G/A rs1392659721 chr11:568157    C/T rs1393385015 chr11:568155    TGC/T rs1394548019 chr11:568152    G/C rs1484589425 chr11:568153    T/C rs758885854 chr11:568158    G/A rs764507105 chr11:568162    G/A rs764507105 chr11:568162    G/T rs887377650 chr11:568163    G/A rs1317060428 chr11:568166    G/A rs1373131153 chr11:568167    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MIDN	chr19:1256335(+) A-I      intronic chr19:1256649(+) A-I      intronic chr19:1256686(+) A-I      intronic chr19:1256695(+) A-I      intronic chr19:1256642(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIDN	chr19:1248583-1248584(+) m6A 5'UTR       24209618//25456834//24981863 chr19:1248645-1248646(+) m6A 5'UTR       24209618//25456834//24981863 chr19:1250001-1250002(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828 chr19:1250152-1250153(+) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:1250202-1250203(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:1250524-1250525(+) m6A CDS       - chr19:1254322-1254323(+) m6A CDS       24284625 chr19:1254907-1254908(+) m6A CDS       24284625//24981863 chr19:1254995-1254996(+) m6A CDS       24284625 chr19:1255050-1255051(+) m6A CDS       24284625 chr19:1255444-1255445(+) m6A CDS       24284625 chr19:1255608-1255609(+) m6A CDS       24284625 chr19:1256996-1256997(+) m6A CDS       24284625//22575960 chr19:1257010-1257011(+) m6A CDS       24284625//22575960 chr19:1257017-1257018(+) m6A CDS       24284625 chr19:1257212-1257213(+) m6A CDS       24284625//24209618//24981863//22575960 chr19:1257324-1257325(+) m6A 3'UTR       24284625//24209618//24981863//22575960 chr19:1257461-1257462(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr19:1257763-1257764(+) m6A 3'UTR       26404942 chr19:1257786-1257787(+) m6A 3'UTR       26404942 chr19:1258032-1258033(+) m6A 3'UTR       24284625 chr19:1258074-1258075(+) m6A 3'UTR       24284625//24981863 chr19:1258143-1258144(+) m6A 3'UTR       24284625//24981863//26404942 chr19:1258181-1258182(+) m6A 3'UTR       25456834//24981863//26404942//27773535 chr19:1258274-1258275(+) m6A 3'UTR       24284625//25456834 chr19:1258854-1258855(+) m6A 3'UTR       27773535 chr19:1259068-1259069(+) m6A 3'UTR       27773535 chr19:1259093-1259094(+) m6A 3'UTR       27773535 chr19:1259125-1259126(+) m6A 3'UTR       27773535 chr19:1259137-1259138(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-210-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Plasma     19289371 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Myotube     27396686 Mitochondrion Skeletal muscle cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815 Nucleus Neural progenitor cells     21363885
	MIDN	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-210-5p
Interactor2: MIDN

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Downregulation
Description	FIG. 2.(B) upregulated miRNAs with their predicted downregulated gene targets.