Detail Information

Basic Information:


  VIRBase ID:  

HHID00096528

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-210-5p:           USP46:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-210-5p USP46
miRBase
Accession/Entrez ID		 MIMAT0026475 64854
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-210-5p
rs1307849834 chr11:568150    C/T
rs1328893125 chr11:568155    T/A
rs1339953548 chr11:568159    G/A
rs1392659721 chr11:568157    C/T
rs1393385015 chr11:568155    TGC/T
rs1394548019 chr11:568152    G/C
rs1484589425 chr11:568153    T/C
rs758885854 chr11:568158    G/A
rs764507105 chr11:568162    G/A
rs764507105 chr11:568162    G/T
rs887377650 chr11:568163    G/A
rs1317060428 chr11:568166    G/A
rs1373131153 chr11:568167    G/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR USP46
chr4:53472550(-) A-I      intronic
chr4:53506806(-) A-I      intronic
chr4:53506854(-) A-I      intronic
chr4:53502810(-) A-I      intronic
chr4:53502688(-) A-I      intronic
chr4:53500780(-) A-I      intronic
chr4:53500768(-) A-I      intronic
chr4:53500759(-) A-I      intronic
chr4:53482748(-) A-I      intronic
chr4:53482735(-) A-I      intronic
chr4:53472549(-) A-I      intronic
chr4:53472517(-) A-I      intronic
chr4:53472534(-) A-I      intronic
chr4:53472548(-) A-I      intronic
chr4:53503074(-) A-I      intronic
chr4:53503061(-) A-I      intronic
chr4:53502790(-) A-I      intronic
chr4:53500441(-) A-I      intronic
chr4:53502787(-) A-I      intronic
chr4:53503178(-) A-I      intronic
chr4:53500484(-) A-I      intronic
chr4:53502761(-) A-I      intronic
chr4:53505966(-) A-I      intronic
chr4:53520771(-) A-I      intronic
chr4:53506861(-) A-I      intronic
chr4:53503147(-) A-I      intronic
chr4:53506887(-) A-I      intronic
chr4:53500864(-) A-I      intronic
chr4:53503150(-) A-I      intronic
chr4:53503015(-) A-I      intronic
chr4:53503116(-) A-I      intronic
chr4:53505992(-) A-I      intronic
chr4:53503045(-) A-I      intronic
chr4:53500455(-) A-I      intronic
chr4:53503098(-) A-I      intronic
chr4:53502773(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED USP46
chr4:53500864(-) A-G intron -    22484847
chr4:53502761(-) A-G intron -    22484847
chr4:53502787(-) A-G intron -    22484847
chr4:53502790(-) A-G intron -    22484847
chr4:53506861(-) A-G intron -    22484847
chr4:53506887(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase USP46
chr4:53457140-53457141(-) m6A 3'UTR       27773535
chr4:53457197-53457198(-) m6A 3'UTR       27773535
chr4:53457329-53457330(-) m6A 3'UTR       24209618//27773535//22608085
chr4:53457368-53457369(-) m6A 3'UTR       24209618//27773535//22608085
chr4:53457383-53457384(-) m6A 3'UTR       24209618//27773535//22608085
chr4:53457508-53457509(-) m6A 3'UTR       27773535
chr4:53457514-53457515(-) m6A 3'UTR       27773535
chr4:53461038-53461039(-) m6A 3'UTR       24981863//22608085
chr4:53461486-53461487(-) m6A 3'UTR       24981863
chr4:53462268-53462269(-) m6A 3'UTR       24981863
chr4:53462298-53462299(-) m6A 3'UTR       24981863//22608085
chr4:53462371-53462372(-) m6A 3'UTR       24981863//22608085
chr4:53462389-53462390(-) m6A 3'UTR       24981863//22608085
chr4:53462397-53462398(-) m6A 3'UTR       24981863//22608085
chr4:53462431-53462432(-) m6A 3'UTR       24981863//22608085
chr4:53462438-53462439(-) m6A 3'UTR       24981863//22608085
chr4:53463669-53463670(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085
chr4:53463788-53463789(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085
chr4:53463797-53463798(-) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-210-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Plasma     19289371
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle cells     27563705
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
Nucleus Neural progenitor cells     21363885
USP46
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-210-5p
Interactor2: USP46

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line PBMC cells Interactor2 expression Downregulation
Description FIG. 2.(B) upregulated miRNAs with their predicted downregulated gene targets.

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