Detail Information

Basic Information:


  VIRBase ID:  

HHID00096507

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4677-3p:           HEBP1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-4677-3p HEBP1
miRBase
Accession/Entrez ID		 MIMAT0019761 50865
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HBP//HEBP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-4677-3p
rs1254655423 chr1:243346244    A/G
rs1481229343 chr1:243346235    C/T
rs771267188 chr1:243346242    C/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HEBP1
chr12:13130505(-) A-I      ncRNA
chr12:13130485(-) A-I      ncRNA
chr12:13130387(-) A-I      ncRNA
chr12:13130423(-) A-I      ncRNA
chr12:13130409(-) A-I      ncRNA
chr12:13131283(-) A-I      intronic
chr12:13130513(-) A-I      intronic
chr12:13131178(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HEBP1
chr12:13127801-13127802(-) m6A 3'UTR       27773535
chr12:13127810-13127811(-) m6A 3'UTR       27773535
chr12:13127836-13127837(-) m6A 3'UTR       27773535
chr12:13127944-13127945(-) m6A 3'UTR       24284625//27773535
chr12:13127992-13127993(-) m6A 3'UTR       24284625//24981863//27773535
chr12:13128171-13128172(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr12:13128221-13128222(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr12:13128228-13128229(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22608085
chr12:13128246-13128247(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr12:13128320-13128321(-) m6A CDS//exon       24284625//24981863//27773535
chr12:13128383-13128384(-) m6A CDS//exon       24284625
chr12:13132450-13132451(-) m6A exon//intron       24209618
chr12:13132474-13132475(-) m6A exon//intron       24209618
chr12:13140166-13140167(-) m6A CDS       -
chr12:13142344-13142345(-) m1A CDS       26863410//26863196
chr12:13152974-13152975(-) m6A CDS       24209618
chr12:13153002-13153003(-) Tm CDS       -
chr12:13153028-13153029(-) m6A CDS       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-4677-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
HEBP1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-4677-3p
Interactor2: HEBP1

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line PBMC cells Interactor2 expression Upregulation
Description FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.

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