Basic Information:

  VIRBase ID:  

HHID00096506

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4677-3p:  MIMAT0019761          APOBEC3C:  NM_014508     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4677-3p	APOBEC3C
miRBase Accession/Entrez ID	MIMAT0019761	27350
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	A3C//APOBEC1L//ARDC2//ARDC4//ARP5//bK150C2.3//PBI

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4677-3p	rs1254655423 chr1:243346244    A/G rs1481229343 chr1:243346235    C/T rs771267188 chr1:243346242    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APOBEC3C	chr22:39412083(+) A-I      intronic chr22:39411932(+) A-I      intronic chr22:39412344(+) A-I      intronic chr22:39411998(+) A-I      intronic chr22:39412010(+) A-I      intronic chr22:39412984(+) A-I      intronic chr22:39413094(+) A-I      intronic chr22:39412983(+) A-I      intronic chr22:39412434(+) A-I      intronic chr22:39412069(+) A-I      intronic chr22:39414764(+) A-I      3'UTR chr22:39414711(+) A-I      3'UTR chr22:39414828(+) A-I      3'UTR chr22:39414761(+) A-I      3'UTR chr22:39414780(+) A-I      3'UTR chr22:39414752(+) A-I      3'UTR chr22:39414847(+) A-I      3'UTR chr22:39414791(+) A-I      3'UTR chr22:39414827(+) A-I      3'UTR chr22:39414808(+) A-I      3'UTR chr22:39411950(+) A-I      intronic chr22:39413441(+) A-I      intronic chr22:39414822(+) A-I      3'UTR chr22:39414777(+) A-I      3'UTR chr22:39414772(+) A-I      3'UTR chr22:39414753(+) A-I      3'UTR chr22:39414717(+) A-I      3'UTR chr22:39411039(+) A-I      intronic chr22:39413078(+) A-I      intronic chr22:39411312(+) A-I      intronic chr22:39412151(+) A-I      intronic chr22:39413538(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	APOBEC3C	chr22:39414754(+) A-I intron -    22327324 chr22:39414772(+) A-I intron -    22327324 chr22:39411950(+) A-G intron -    22484847 chr22:39414754(+) A-G intron -    22484847 chr22:39414772(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APOBEC3C	chr22:39410152-39410153(+) m6A 5'UTR       24981863 chr22:39410179-39410180(+) m6A 5'UTR       24981863 chr22:39410337-39410338(+) m6A 5'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr22:39410343-39410344(+) m6A 5'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr22:39410365-39410366(+) m6A 5'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr22:39411601-39411602(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr22:39411649-39411650(+) m6A CDS//intron       24284625//24981863//26404942//22575960//22608085 chr22:39414467-39414468(+) m6A 3'UTR       24284625 chr22:39414565-39414566(+) m6A 3'UTR       24284625//25456834//24981863 chr22:39414620-39414621(+) m6A 3'UTR       24284625//25456834//24981863 chr22:39414692-39414693(+) m6A 3'UTR       24284625//24981863 chr22:39414787-39414788(+) m6A 3'UTR       24981863 chr22:39414942-39414943(+) m6A 3'UTR       25456834//24981863 chr22:39414961-39414962(+) m6A 3'UTR       25456834//24981863 chr22:39414986-39414987(+) m6A 3'UTR       25456834//24981863 chr22:39415015-39415016(+) m6A 3'UTR       24981863 chr22:39415026-39415027(+) m6A 3'UTR       24981863 chr22:39415053-39415054(+) m6A 3'UTR       24981863 chr22:39415070-39415071(+) m6A 3'UTR       25456834//24981863 chr22:39415127-39415128(+) m6A 3'UTR       25456834//24981863//22608085 chr22:39415188-39415189(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr22:39415214-39415215(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr22:39415234-39415235(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr22:39415280-39415281(+) m6A 3'UTR       24284625//24981863//22608085 chr22:39415315-39415316(+) m6A 3'UTR       24284625//24981863//22608085 chr22:39415370-39415371(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4677-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	APOBEC3C	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4677-3p
Interactor2: APOBEC3C

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.