Basic Information:

  VIRBase ID:  

HHID00096499

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4677-3p:  MIMAT0019761          TSHR:  NM_000369     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4677-3p	TSHR
miRBase Accession/Entrez ID	MIMAT0019761	7253
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHNG1//hTSHR-I//LGR3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4677-3p	rs1254655423 chr1:243346244    A/G rs1481229343 chr1:243346235    C/T rs771267188 chr1:243346242    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TSHR	chr14:81588126(+) A-I      intronic chr14:81588085(+) A-I      intronic chr14:81588110(+) A-I      intronic chr14:81588125(+) A-I      intronic chr14:81588121(+) A-I      intronic chr14:81589250(+) A-I      intronic chr14:81433903(+) A-I      intronic chr14:81589360(+) A-I      intronic chr14:81589383(+) A-I      intronic chr14:81546063(+) A-I      intronic chr14:81589268(+) A-I      intronic chr14:81433673(+) A-I      intronic chr14:81490838(+) A-I      intronic chr14:81561848(+) A-I      intronic chr14:81589400(+) A-I      intronic chr14:81545946(+) A-I      intronic chr14:81588552(+) A-I      intronic chr14:81433729(+) A-I      intronic chr14:81546064(+) A-I      intronic chr14:81546014(+) A-I      intronic chr14:81589311(+) A-I      intronic chr14:81561860(+) A-I      intronic chr14:81589350(+) A-I      intronic chr14:81561871(+) A-I      intronic chr14:81514095(+) A-I      intronic chr14:81588066(+) A-I      intronic chr14:81588124(+) A-I      intronic chr14:81588165(+) A-I      intronic chr14:81546077(+) A-I      intronic chr14:81588567(+) A-I      intronic chr14:81588648(+) A-I      intronic chr14:81588570(+) A-I      intronic chr14:81608608(+) A-I      intronic chr14:81589403(+) A-I      intronic chr14:81588095(+) A-I      intronic chr14:81588057(+) A-I      intronic chr14:81604588(+) A-I      intronic chr14:81589205(+) A-I      intronic chr14:81533500(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSHR	chr14:81421498-81421499(+) m6A 5'UTR//exon       - chr14:81421516-81421517(+) m6A 5'UTR//exon       - chr14:81421534-81421535(+) m6A 5'UTR//exon       - chr14:81421802-81421803(+) m6A 5'UTR//intron       - chr14:81609516-81609517(+) m6A CDS       - chr14:81609530-81609531(+) m6A CDS       - chr14:81609576-81609577(+) m6A CDS       - chr14:81609585-81609586(+) m6A CDS       - chr14:81609630-81609631(+) m6A CDS       - chr14:81609736-81609737(+) m6A CDS       27773535 chr14:81609822-81609823(+) m6A CDS       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4677-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	TSHR	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4677-3p
Interactor2: TSHR

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.