Basic Information:

  VIRBase ID:  

HHID00096496

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4677-3p:  MIMAT0019761          SLC31A2:  NM_001860     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4677-3p	SLC31A2
miRBase Accession/Entrez ID	MIMAT0019761	1318
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COPT2//CTR2//hCTR2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4677-3p	rs1254655423 chr1:243346244    A/G rs1481229343 chr1:243346235    C/T rs771267188 chr1:243346242    C/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC31A2	chr9:115914086(+) A-I      ncRNA chr9:115914134(+) A-I      ncRNA chr9:115916326(+) A-I      intronic chr9:115916283(+) A-I      intronic chr9:115921540(+) A-I      intronic chr9:115921466(+) A-I      intronic chr9:115922259(+) A-I      intronic chr9:115921577(+) A-I      intronic chr9:115921587(+) A-I      intronic chr9:115916393(+) A-I      intronic chr9:115916379(+) A-I      intronic chr9:115922423(+) A-I      intronic chr9:115914158(+) A-I      ncRNA chr9:115922253(+) A-I      intronic chr9:115916332(+) A-I      intronic chr9:115916288(+) A-I      intronic chr9:115921687(+) A-I      intronic chr9:115921528(+) A-I      intronic chr9:115916380(+) A-I      intronic chr9:115921552(+) A-I      intronic chr9:115914060(+) A-I      ncRNA chr9:115914113(+) A-I      ncRNA chr9:115922346(+) A-I      intronic chr9:115916271(+) A-I      intronic chr9:115922299(+) A-I      intronic chr9:115914166(+) A-I      ncRNA chr9:115922294(+) A-I      intronic chr9:115922302(+) A-I      intronic chr9:115922200(+) A-I      intronic chr9:115921550(+) A-I      intronic chr9:115916443(+) A-I      intronic chr9:115914163(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC31A2	chr9:115914055(+) A-I intron -    15258596 chr9:115914056(+) A-I intron -    15258596 chr9:115914060(+) A-I intron -    15258596 chr9:115914158(+) A-I intron -    15258596 chr9:115914163(+) A-I intron -    15258596 chr9:115921466(+) A-I intron -    15342557 chr9:115921515(+) A-I intron -    15342557 chr9:115921540(+) A-I intron -    15342557 chr9:115921550(+) A-I intron -    15342557 chr9:115921552(+) A-I intron -    15342557 chr9:115921577(+) A-I intron -    15342557 chr9:115921587(+) A-I intron -    15342557 chr9:115922199(+) A-I intron -    15342557 chr9:115922200(+) A-I intron -    15342557 chr9:115922253(+) A-I intron -    15342557 chr9:115922254(+) A-I intron -    15342557 chr9:115922259(+) A-I intron -    15342557 chr9:115922293(+) A-I intron -    15342557 chr9:115922294(+) A-I intron -    15342557 chr9:115922297(+) A-I intron -    15342557 chr9:115922299(+) A-I intron -    15342557 chr9:115922302(+) A-I intron -    15342557 chr9:115922336(+) A-I intron -    15342557 chr9:115922346(+) A-I intron -    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC31A2	chr9:115913230-115913231(+) m6A 5'UTR       24981863 chr9:115913288-115913289(+) m6A 5'UTR//exon       24981863 chr9:115913307-115913308(+) m6A 5'UTR//exon       24981863 chr9:115913966-115913967(+) m6A exon//intron       24981863 chr9:115925232-115925233(+) m6A 3'UTR       24284625//24981863//22608085 chr9:115925253-115925254(+) m6A 3'UTR       24284625//24981863//22608085 chr9:115925319-115925320(+) m6A 3'UTR       24284625//24981863//22608085 chr9:115925426-115925427(+) m6A 3'UTR       24284625//24981863//22608085 chr9:115925510-115925511(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:115925571-115925572(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925577-115925578(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925630-115925631(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925658-115925659(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925664-115925665(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925703-115925704(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr9:115925742-115925743(+) m6A 3'UTR       24284625//24981863//22608085 chr9:115925770-115925771(+) m6A 3'UTR       24284625//24981863//22608085 chr9:115925851-115925852(+) m6A 3'UTR       24284625//24981863//22608085 chr9:115925860-115925861(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925913-115925914(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925920-115925921(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115925954-115925955(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr9:115926077-115926078(+) m6A 3'UTR       24284625//22608085 chr9:115926161-115926162(+) m6A 3'UTR       24981863//22608085 chr9:115926259-115926260(+) m6A 3'UTR       24981863//22608085 chr9:115926276-115926277(+) m6A 3'UTR       24981863//22608085 chr9:115926378-115926379(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4677-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	SLC31A2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4677-3p
Interactor2: SLC31A2

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRNet
Support Database	ViRBase

References:

PMID	33045840	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	PBMC cells	Interactor2 expression	Upregulation
Description	FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.