Detail Information

Basic Information:


  VIRBase ID:  

HHID00096484

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           TMEM106A:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 TMEM106A
miRBase
Accession/Entrez ID		 MIMAT0005929 113277
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM106A
chr17:41370650(+) A-I      3'UTR
chr17:41370496(+) A-I      3'UTR
chr17:41370502(+) A-I      3'UTR
chr17:41370515(+) A-I      3'UTR
chr17:41370520(+) A-I      3'UTR
chr17:41370521(+) A-I      3'UTR
chr17:41370441(+) A-I      3'UTR
chr17:41370137(+) A-I      3'UTR
chr17:41371551(+) A-I      3'UTR
chr17:41370549(+) A-I      3'UTR
chr17:41370168(+) A-I      3'UTR
chr17:41370470(+) A-I      3'UTR
chr17:41370484(+) A-I      3'UTR
chr17:41370124(+) A-I      3'UTR
chr17:41370625(+) A-I      3'UTR
chr17:41370629(+) A-I      3'UTR
chr17:41370163(+) A-I      3'UTR
chr17:41367100(+) A-I      intronic
chr17:41370112(+) A-I      3'UTR
chr17:41366817(+) A-I      intronic
chr17:41370465(+) A-I      3'UTR
chr17:41370460(+) A-I      3'UTR
chr17:41370433(+) A-I      3'UTR
chr17:41370504(+) A-I      3'UTR
chr17:41371487(+) A-I      3'UTR
chr17:41370416(+) A-I      3'UTR
chr17:41370424(+) A-I      3'UTR
chr17:41371515(+) A-I      3'UTR
chr17:41370179(+) A-I      3'UTR
chr17:41370518(+) A-I      3'UTR
chr17:41370582(+) A-I      3'UTR
chr17:41370448(+) A-I      3'UTR
chr17:41370565(+) A-I      3'UTR
chr17:41370533(+) A-I      3'UTR
chr17:41370165(+) A-I      3'UTR
chr17:41370601(+) A-I      3'UTR
chr17:41371511(+) A-I      3'UTR
chr17:41370519(+) A-I      3'UTR
chr17:41370138(+) A-I      3'UTR
chr17:41370592(+) A-I      3'UTR
chr17:41370503(+) A-I      3'UTR
chr17:41370667(+) A-I      3'UTR
chr17:41370418(+) A-I      3'UTR
chr17:41370608(+) A-I      3'UTR
chr17:41370164(+) A-I      3'UTR
chr17:41370177(+) A-I      3'UTR
chr17:41370595(+) A-I      3'UTR
chr17:41371491(+) A-I      3'UTR
chr17:41370494(+) A-I      3'UTR
chr17:41370089(+) A-I      3'UTR
chr17:41370125(+) A-I      3'UTR
chr17:41370087(+) A-I      3'UTR
chr17:41367269(+) A-I      intronic
chr17:41371497(+) A-I      3'UTR
chr17:41370586(+) A-I      3'UTR
chr17:41366171(+) A-I      intronic
chr17:41366859(+) A-I      intronic
chr17:41370662(+) A-I      3'UTR
chr17:41371525(+) A-I      3'UTR
chr17:41371489(+) A-I      3'UTR
chr17:41370101(+) A-I      3'UTR
chr17:41370569(+) A-I      3'UTR
chr17:41370612(+) A-I      3'UTR
chr17:41370524(+) A-I      3'UTR
chr17:41370640(+) A-I      3'UTR
chr17:41370425(+) A-I      3'UTR
chr17:41371454(+) A-I      3'UTR
chr17:41370630(+) A-I      3'UTR
chr17:41370473(+) A-I      3'UTR
chr17:41371481(+) A-I      3'UTR
chr17:41370093(+) A-I      3'UTR
chr17:41370559(+) A-I      3'UTR
chr17:41370529(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM106A
chr17:41367270(+) G-A intron -    22484847
chr17:41370087(+) A-G intron -    22484847
chr17:41370164(+) A-G intron -    22484847
chr17:41370179(+) A-G intron -    22484847
chr17:41370416(+) A-G intron -    22484847
chr17:41370418(+) A-G intron -    22484847
chr17:41370424(+) A-G intron -    22484847
chr17:41370433(+) A-G intron -    22484847
chr17:41370460(+) A-G intron -    22484847
chr17:41370465(+) A-G intron -    22484847
chr17:41370504(+) A-G intron -    22484847
chr17:41370518(+) A-G intron -    22484847
chr17:41370524(+) A-G intron -    22484847
chr17:41370529(+) A-G intron -    22484847
chr17:41370533(+) A-G intron -    22484847
chr17:41370565(+) A-G intron -    22484847
chr17:41370569(+) A-G intron -    22484847
chr17:41370592(+) A-G intron -    22484847
chr17:41370601(+) A-G intron -    22484847
chr17:41370608(+) A-G intron -    22484847
chr17:41370630(+) A-G intron -    22484847
chr17:41370667(+) A-G intron -    22484847
chr17:41371491(+) A-G intron -    22484847
chr17:41371497(+) A-G intron -    22484847
chr17:41371515(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM106A
chr17:41364246-41364247(+) m6A 5'UTR//exon//intron       -
chr17:41364402-41364403(+) m6A 5'UTR//exon//intron       -
chr17:41364408-41364409(+) m6A 5'UTR//exon//intron       -
chr17:41365043-41365044(+) m6A 5'UTR//exon//intron       -
chr17:41369767-41369768(+) m6A CDS       -
chr17:41369898-41369899(+) m6A 3'UTR       -
chr17:41370601-41370602(+) m6A 3'UTR       -
chr17:41370669-41370670(+) m6A 3'UTR       -
chr17:41370687-41370688(+) m6A 3'UTR       -
chr17:41371580-41371581(+) m6A 3'UTR       -
chr17:41371795-41371796(+) m6A 3'UTR       24284625
chr17:41371807-41371808(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
TMEM106A
Chromatin K562 cells     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: TMEM106A

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line PBMC cells Interactor2 expression Upregulation
Description FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.

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