Detail Information

Basic Information:


  VIRBase ID:  

HHID00096483

  Virus:  

Human immunodeficiency virus (HIV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-1275:           PLCD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-1275 PLCD3
miRBase
Accession/Entrez ID		 MIMAT0005929 113026
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - PLC-delta-3

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-1275
rs372458638 chr6:34000019    A/AAAACC
rs377188203 chr6:34000023    C/T
rs557928121 chr6:34000019    A/T
rs758811783 chr6:34000022    G/A
rs761034364 chr6:34000017    AGAC/A
rs370361021 chr6:34000029    C/A
rs370361021 chr6:34000029    C/T
rs374728385 chr6:34000032    C/A
rs374728385 chr6:34000032    C/G
rs747378297 chr6:34000028    C/T
rs772691699 chr6:34000033    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLCD3
chr17:43204137(-) A-I      intronic
chr17:43206740(-) A-I      intronic
chr17:43202375(-) A-I      intronic
chr17:43202451(-) A-I      intronic
chr17:43202911(-) A-I      intronic
chr17:43202916(-) A-I      intronic
chr17:43202917(-) A-I      intronic
chr17:43204177(-) A-I      intronic
chr17:43204209(-) A-I      intronic
chr17:43202475(-) A-I      intronic
chr17:43202373(-) A-I      intronic
chr17:43202747(-) A-I      intronic
chr17:43199228(-) A-I      intronic
chr17:43202625(-) A-I      intronic
chr17:43202852(-) A-I      intronic
chr17:43204267(-) A-I      intronic
chr17:43203901(-) A-I      intronic
chr17:43203915(-) A-I      intronic
chr17:43203942(-) A-I      intronic
chr17:43189360(-) A-I      3'UTR
chr17:43206629(-) A-I      intronic
chr17:43202842(-) A-I      intronic
chr17:43203444(-) A-I      intronic
chr17:43202446(-) A-I      intronic
chr17:43202880(-) A-I      intronic
chr17:43204226(-) A-I      intronic
chr17:43199200(-) A-I      intronic
chr17:43203943(-) A-I      intronic
chr17:43202450(-) A-I      intronic
chr17:43202339(-) A-I      intronic
chr17:43202927(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PLCD3
chr17:43204226(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLCD3
chr17:43188813-43188814(-) m6A 3'UTR       24981863
chr17:43189067-43189068(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr17:43189265-43189266(-) m6A 3'UTR       24284625//24209618
chr17:43189286-43189287(-) m6A 3'UTR       24284625//24209618
chr17:43189335-43189336(-) m6A 3'UTR       24284625//24209618
chr17:43189401-43189402(-) m6A 3'UTR       24284625//24209618//24981863//22575960
chr17:43189434-43189435(-) m6A 3'UTR       24284625//24209618//24981863//22575960
chr17:43189497-43189498(-) m6A 3'UTR       24284625//24209618//24981863//22575960
chr17:43189518-43189519(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr17:43189656-43189657(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr17:43189670-43189671(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr17:43189796-43189797(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr17:43190356-43190357(-) m6A CDS//exon//intron       24284625
chr17:43190510-43190511(-) m6A CDS//exon       24284625//22575960
chr17:43190527-43190528(-) m6A CDS//exon       24284625//22575960
chr17:43190566-43190567(-) m6A CDS//exon       24284625//22575960
chr17:43190823-43190824(-) m6A CDS//exon       24284625//22575960
chr17:43190833-43190834(-) m6A CDS//exon       24284625//22575960
chr17:43190884-43190885(-) m6A CDS//exon       22575960
chr17:43190936-43190937(-) m6A CDS//exon       22575960
chr17:43190963-43190964(-) m6A CDS//exon//intron       22575960
chr17:43191634-43191635(-) m6A CDS//exon       24284625
chr17:43191667-43191668(-) m6A CDS//exon       24284625//27773536
chr17:43191730-43191731(-) m6A CDS//exon       24284625//27371828//27773536
chr17:43192477-43192478(-) m6A CDS//exon//intron       24284625//27371828//27773536
chr17:43192634-43192635(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//27773536
chr17:43192744-43192745(-) m1A CDS//exon       26863196
chr17:43192783-43192784(-) Cm CDS//exon       -
chr17:43194032-43194033(-) m6A CDS//exon       24284625//22575960
chr17:43194056-43194057(-) m6A CDS//exon       24284625//22575960
chr17:43194116-43194117(-) m6A CDS       24284625//22575960
chr17:43195469-43195470(-) m6A CDS//exon       24284625
chr17:43195753-43195754(-) m6A CDS//exon       24284625//26404942
chr17:43195759-43195760(-) m6A CDS//exon       24284625//26404942
chr17:43195786-43195787(-) m6A CDS//exon//intron       24284625//26404942//22575960
chr17:43196184-43196185(-) m6A CDS//exon       24284625//25456834//24981863
chr17:43196202-43196203(-) m6A CDS//exon       24284625//25456834//24981863
chr17:43196252-43196253(-) m6A CDS//exon       24284625//25456834//24981863//27773536//22575960
chr17:43196294-43196295(-) m6A CDS//exon       24284625//25456834//24981863//27773536//22575960
chr17:43197725-43197726(-) m6A CDS       24284625
chr17:43197759-43197760(-) Gm CDS       -
chr17:43197779-43197780(-) m6A CDS       27773536
chr17:43198271-43198272(-) m6A CDS       27773536
chr17:43198370-43198371(-) m6A CDS       27773536//22575960
chr17:43198376-43198377(-) m6A CDS       27773536//22575960
chr17:43206615-43206616(-) m6A exon//intron       24284625//27773536
chr17:43209620-43209621(-) m1A CDS//exon//intron       26863196//26863410
chr17:43209809-43209810(-) m6A 5'UTR//exon//intron       24209618//24981863//27773536
chr17:43210476-43210477(-) m6A 5'UTR//intron       24981863
chr17:43210490-43210491(-) m6A 5'UTR//intron       24981863
chr17:43210497-43210498(-) m6A 5'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-1275
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells     -
Mitochondrion HeLa cells     27396686
Mitochondrion HeLa cells     27563705
Mitochondrion Cell line (HeLa)     21695135
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
PLCD3
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-1275
Gemcitabine 60750 Drug interaction    RC00007825
Vincristine 5978 Drug interaction    RC00007823
Eloxatine 5310940 Drug interaction    RC00007826
Paclitaxel 36314 Drug interaction    RC00007824
5-Fluorouracil 3385 Drug interaction    RC00007822
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007821
Marine fungal metabolite 1386A - Drug interaction    RC00007827
Resource Symbol Drug Name PubChem ID
RNAactDrug hsa-miR-1275
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-1275
Interactor2: PLCD3

Evidence Support:


Weak-Evidence Small RNA sequencing
Prediction-Evidence miRNet
Support Database ViRBase

References:


PMID 33045840 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line PBMC cells Interactor2 expression Upregulation
Description FIG. 2.(A) Downregulated miRNAs with their predicted upregulated gene targets.

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